CDC Researchers Blame JUUL for Rise in Teen Vaping


“JUUL’s high nicotine concentration, discreet shape, and flavors could be particularly appealing to, and problematic for, youths.”

Science says vaping is cool. Okay, maybe science doesn’t directly say that, but evidence shows that more and more teens are using e-cigarettes, and teens are cool, so vaping must be cool, right? Unfortunately, public health officials at the US Centers for Disease Control and Prevention disagree. And they’re placing much of the blame for the rise in teen vaping on one company: the Silicon Valley e-cigarette startup JUUL Laboratories.

In a research letter published Tuesday in the Journal of the American Medical Association, researchers at the CDC and nonprofit RTI International’s Centers for Health Policy Science and Tobacco Research analyzed data from retailers across the country and outlined how JUUL’s meteoric rise in popularity may be accredited — at least in part — to its appeal among teenagers. While all e-cigarette brands increased in popularity between 2013 and 2017 because of marketing suggesting that they help people quit smoking, JUUL has become the most in-demand manufacturer of all.

“JUUL’s high nicotine concentration, discreet shape, and flavors could be particularly appealing to, and problematic for, youths,” wrote the study’s authors, led by Brian King, Ph.D., M.P.H., deputy director for research translation in the CDC’s Office on Smoking and Health.

Many teens may initially try e-cigarettes, like those manufactured by JUUL, because they’re seen as safer alternatives to traditional tobacco cigarettes. And JUUL’s sleek, compact design makes the device look like a USB drive, meaning it can easily be slipped into a pocket or concealed in the palm of the hand. Several reports suggest teens easily sneak it into classrooms. Its modular “pod” design also makes it easy for users to refill the nicotine-containing liquid by simply switching out a coin-sized cartridge. Compared to disposable devices with integrated batteries, JUUL’s rechargeable device offers several attractive qualities to many consumers, and the numbers bear this out.

According to the study’s authors, JUUL Laboratories sales increased by a whopping 641 percent from 2016 to 2017. This growth translated to a 515 percent increase in JUUL Laboratories’ share of the e-cigarette market, jumping from just 2 percent of the vape market when the company started to 13 percent in early 2017. The company’s hold on the vape market exploded after that, and as of December 2017, the company controlled 29 percent of e-cigarette sales. This means that almost one out of every three e-cigarettes purchased in the US is a JUUL.

Notably, the study only used purchasing data from retailers, so it was not possible for researchers to determine how old buyers were. The study’s authors did note, though, that previous research has suggested many of these purchases may have been made by consumers under the legal smoking age.

“These sales could reflect products purchased by adults to attempt smoking cessation or products obtained directly or indirectly by youths; a recent analysis found retail stores were the primary location where youths reported obtaining the JUUL device and refill pods,” they wrote.

JUUL podmod starter kit
A JUUL starter pack includes the device, a USB charger, and four pods of different flavored nicotine-containing e-liquid, all for less than $50.

In response to Inverse’s request for comment on the new paper, JUUL spokesperson Victoria Davis did not address the assertion that JUUL products are popular among young people. Davis did emphasize targeting “adult smokers” three times, though:

JUUL Labs is focused on its mission to improve the lives of the world’s one billion adult smokers. Like many Silicon Valley technology startups, our growth is the result of a superior product disrupting an archaic industry — in this case, one whose products are the number one cause of preventable death. When adult smokers find a satisfying alternative to cigarettes, they tell other adult smokers. JUUL Labs has helped more than 1 million Americans switch from cigarettes, and we’re excited about our continued expansion into markets outside of the United States such as the United Kingdom, Canada, and Israel.

This public relations tactic is becoming familiar territory for JUUL, whose official Instagram page is dominated by images of full-on adult adults, including testimonials from people like 68-year-old Kathy, a gray-haired woman named Barbara, and the rapper/actress Awkwafina, who, at 29 years old is young but no teen. The explicit focus on adults may be coming a little too late for the company, though, as it’s already in federal regulators’ crosshairs.

On September 13, Inverse reported that US Food and Drug Administration Commissioner Scott Gottlieb, M.D., announced that vaping had become an “epidemic.” Gottlieb noted that the FDA had issued 56 warning letters to retailers who illegally sold the devices to kids under 18 years old, and JUUL was specifically mentioned in his announcement. This week, the FDA also announced it had raided JUUL’s headquarters on Friday, seizing thousands of pages of documents. The operation was part of an investigation into whether JUUL has been marketing its products to children.

Brain Scans Reveal How Drinking Turns People Into Raging Assholes


We all have that friend who gets a little out of hand when they start drinking alcohol. Maybe he gets loud, or maybe she starts fights with strangers for looking at her funny. Alcohol seems to induce aggression, changing the brain in a way that makes a drunk person more likely to see minor social cues as threats, but how it does so has always been a bit of biological mystery.

Scientists found that alcohol-induced aggression was correlated to decreased activity in the prefrontal cortex.

But in a paper published in the journal Cognitive, Affective, & Behavioral Neuroscience, a team of researchers led by Thomas Denson, Ph.D., of the University of New South Wales School of Psychology use brain scans to show that alcohol changes activity in certain key parts of the brain related to aggression and emotion.

Using functional magnetic resonance imaging (fMRI), a technique that tracks changes in blood flow in the brain, the team looked at the brains of 50 young men after they consumed either two alcoholic drinks or two non-alcoholic placebo drinks. These volunteers engaged in a task that gauged their level of aggression in the face of provocation, which revealed the parts of the brain that become more active in such situations.

These scans show how alcohol-induced aggression was related to decreased activity in the prefrontal cortex, caudate, and ventral striatum, but increased activity in the hippocampus.
These scans show how alcohol-induced aggression was related to decreased activity in the prefrontal cortex, caudate, and ventral striatum, but increased activity in the hippocampus.

The researchers found that alcohol-induced aggression was correlated with decreased activity in prefrontal cortex, caudate, and ventral striatum, but increased activity in the hippocampus. These parts of the brain all control key factors in aggression: The prefrontal cortex is associated with thoughtful action and social behavior, the caudate is linked to the brain’s reward system and inhibitory control, and the ventral striatum is a part of the reward system that makes you feel good when you do something good. The hippocampus, meanwhile, is associated with emotion and memory.

These results support previous hypotheses that prefrontal cortex dysfunction is associated with alcohol-induced aggression. Taking all these brain areas together, the researchers say their findings suggest that intoxicated people have trouble processing information through their working memory. In short, they suspect that alcohol focuses a person’s attention on the cues that could instigate aggression while taking attention away from their knowledge of social norms that say violence is not acceptable.

Along similar lines, they also suspect that alcohol could make relatively minor cues seem aggressive or violent, which can cause a drunk person to overreact to a minor incident, like someone looking at them funny or accidentally bumping into them at the bar. Denson’s previous research on the angry brain found a lot of overlap in the way the prefrontal cortex behaves when someone is drunk and angry versus when they’re simply ruminating on their anger while sober.

This research proposes some possible brain biomarkers for alcohol-induced aggression, which is a significant public health issue. According to the Centers for Disease Control and Prevention, in the United States, alcohol-related violence — including homicide, child abuse, suicide, and firearm injuries — was responsible for more than 16,000 deaths between 2006 and 2010, the most recent years the agency reported figures.

While the new study doesn’t propose a solution per se, it does build on our body of knowledge around an age-old question: Why do some people become assholes when they get drunk?

Abstract: Alcohol intoxication is implicated in approximately half of all violent crimes. Over the past several decades, numerous theories have been proposed to account for the influence of alcohol on aggression. Nearly all of these theories imply that altered functioning in the prefrontal cortex is a proximal cause. In the present functional magnetic resonance imaging (fMRI) experiment, 50 healthy young men consumed either a low dose of alcohol or a placebo and completed an aggression paradigm against provocative and nonprovocative opponents. Provocation did not affect neural responses. However, relative to sober participants, during acts of aggression, intoxicated participants showed decreased activity in the prefrontal cortex, caudate, and ventral striatum, but heightened activation in the hippocampus. Among intoxicated participants, but not among sober participants, aggressive behavior was positively correlated with activation in the medial and dorsolateral prefrontal cortex. These results support theories that posit a role for prefrontal cortical dysfunction as an important factor in intoxicated aggression.

Latent HIV Reservoir May Be Larger Than Previous Estimates


The sleeping giant of HIV infection—a reservoir of viral DNA that lies dormant in human immune cells—could be far larger than previously believed.

A study published today in the journal Cell shows that the reservoir, consisting of proviruses integrated into resting CD4 immune cells, may be 60 times larger than scientists had estimated. Antiretroviral therapy (ART) kills replicating HIV but not the latent proviruses, which pose a major barrier to eradicating the virus from the body and curing infection.

The latent HIV reservoir in people who are infected could be 60 times larger than previously estimated, according to a new study. Image:  JAMA, ©AMA

Recent research had indicated that fewer than 1% of proviruses become infectious when resting CD4 cells are activated in a test tube. Without activation, proviruses can’t replicate. The proviruses that don’t cause infection have been considered defective, but investigators hadn’t described specifics about the deficiencies.

In the new study, a team of investigators used a more detailed method to study proviruses that didn’t switch on and become infectious when the resting CD4 cells they inhabited were activated in the laboratory. They cloned the genomes of 213 inactive proviruses from 8 HIV-infected patients treated with ART for more than 6 months. Their genetic analyses showed that about 88% of proviruses that didn’t turn on had obvious defects that prevented them from replicating. But nearly 12%—a far greater percentage than previously estimated—were capable of replicating and causing infection.

The investigators said their study suggests that there are enough proviruses that don’t turn on but are capable of replicating to boost the size of the latent reservoir by 60-fold. “These results indicate an increased barrier to cure, as all intact noninduced proviruses need to be eradicated,” senior author Robert Siliciano, MD, PhD, of Johns Hopkins University School of Medicine in Baltimore, said in a statement.

“We would like to use these findings by developing better ways to measure the size of the latent reservoir in patients who are participating in future trials of potentially curative strategies,” Siliciano added. “In this way, we think our analysis will contribute to HIV eradication efforts.”

Rare Q fever outbreak reported in American medical tourists


Five Americans came down with an unusual illness after traveling to Germany for a controversial treatment involving injections with sheep cells, health officials reported Wednesday.

The treatment is not permitted in the U.S. The New York residents received the “live cell therapy” in May last year. About a week later, they developed fever, fatigue and other symptoms of a dangerous bacterial illness called Q fever.

Two told investigators that they were part of a group that, for the last five years, had traveled to Germany twice a year for the injections. They said they get them to improve their health and vitality. There is no published clinical proof the treatments work, health officials say.

The Centers for Disease Control and Prevention on Wednesday released a report on the outbreak, which included a Canadian case — another medical tourist who got the treatment in Germany at about the same time. The four women and two men ranged in age from 59 to 83.

Live or fresh cell therapy involves injecting people with fetal cells from sheep. It’s sometimes offered as an anti-aging therapy, but also has been touted as a treatment for conditions ranging from impotence to migraines to liver disease.

Q fever is caused by a hardy germ found in cattle, sheep and goats. People usually get it from inhaling barnyard dust — it’s an occupational hazard for farmers.

But cases in the U.S. are unusual — each year fewer than 200 are reported. It is treated with antibiotics and U.S. residents rarely die from Q fever; three or four deaths are reported in the worst years.

Wayne C. Koff describes a scientific project that promises to accelerate the development of next-generation weapons in the fight against deadly infectious diseases.


Vaccines are one of the great success stories in the history of individual and public health. They have helped rid the planet of the scourge of smallpox, are poised to eliminate polio, and each year prevent millions of deaths, reducing the suffering and costs caused by infectious diseases.

But there are still many diseases for which vaccines do not yet exist. Moreover, strategies that have previously led to the successful development of vaccines are unlikely to work against more complex bacteria or viruses, such as HIV, which have evolved multiple mechanisms to evade the immune system.

The history of vaccinology is one in which biomedical and technological advances usher in the “next generation” of vaccines. In the 1950’s, a breakthrough that enabled viruses to grow in tissue cultures led to the development of both live attenuated vaccines and inactivated vaccines for measles, polio, and other diseases. In the 1980’s, recombinant DNA technology led to the development of vaccines against hepatitis B and human papillomavirus.

Around the turn of the century, the first sequencing of the human genome led to “reverse vaccinology.” This approach, whereby computational analysis of a pathogen’s genome enables identification and screening of a great many more potential vaccine targets than was previously possible, was used in the successful development of a vaccine against meningitis B.

The past decade has already yielded major advances in structure-assisted vaccine discovery, synthetic biology, systems biology, and immune monitoring. However, successfully translating these advances into the development of next-generation vaccines continues to be impeded by gaps in our understanding of the human immune response that protects against specific bacteria, viruses, or parasites.

That is why I, along with eight fellow scientists, have proposed the establishment of a new human-immunology-based clinical-research initiative, the Human Vaccines Project. In February 2014, leading scientists and public-health specialists will gather in La Jolla, California, to craft a scientific plan to identify, prioritize, and, most important, solve the major problems currently hindering development of vaccines against diseases such as AIDS, tuberculosis, and malaria.

Such a project would represent a paradigm shift in vaccine development. The current process is long (often spanning decades from concept to licensure), has a low probability of success (because of the limitations of animal models in predicting immune response and efficacy in humans), and is costly (often requiring hundreds of millions of dollars to develop a single vaccine).

Consider this: In just the past few years, many candidate vaccines against HIV, dengue, herpes, tuberculosis, and staphylococcus aureus have failed, at a cost of more than $1 billion. Investing that amount over the next decade in a coordinated effort to address the major questions facing vaccine development would rapidly accelerate our search for effective solutions, implying a transformative impact on individual and public health.

HIV presents perhaps the greatest challenge, because the virus leverages its extensive genetic variability to hide from the immune system. Using recent advances, however, scientists have now identified highly conserved regions of this variable virus, determined their molecular structure, and begun designing next-generation vaccine candidates to elicit antibodies that target these regions to prevent HIV infection. But HIV vaccine development, like that for several other diseases, is still impeded by the limitations of what animal models can tell us about how to elicit the necessary immune responses in humans.

Two recent advances could accelerate vaccine development and reduce its costs dramatically. In synthetic biology, the rapid engineering of nucleic acid-based vaccines means more candidates move more quickly from concept to trial. In systems biology, high-throughput technologies have increased the number of genetic and immunologic parameters assessed in trials. This approach has helped predict the efficacy of potential new-generation vaccines against yellow fever and influenza within days of immunization, compared with the usual timeframe of months or years.

Vaccines already prevent the deaths of 2-3 million people every year, preempt human suffering, lighten the burden placed on health-care systems, and enable more rapid economic and social development. Models show that adding even a partly effective AIDS vaccine to the current range of prevention and treatment procedures could dramatically lower the rate of HIV infection.

As the Nobel Peace Prize laureate Desmond Tutu, one of the world’s great campaigners against HIV/AIDS, wrote recently: “We must make the most of scientific advances over the last half-century, which have made vaccines for other preventable diseases the most powerful and cost-effective health-care investment that currently exists.”

That is the idea behind the Human Vaccines Project – a concept that would have been unimaginable even a decade ago. Today, technological advances in vaccine discovery and immune monitoring allow us realistically to explore this potentially game-changing approach to disease prevention. February’s gathering in California may take us a giant step closer to a world without deadly and debilitating infectious diseases.

Antibiotics are ‘not for snot’


Running noses and green phlegm do not mean patients need antibiotics, say doctors and public health experts.

It was described as a “prevailing myth” that the drugs were needed to treat such infections.

Snotty child

Public Health England and the Royal College of General Practitioners said the symptoms were often caused by viruses.

And the use of antibiotics was leading to resistance, they said.

Public Health England said its own research showed that 40% of people thought antibiotics would help a cough if the phlegm was green, while very few thought it would make a difference to clear-coloured phlegm.

Dr Cliodna McNulty, from the organisation, said: “It’s a prevailing myth that anyone with green phlegm or snot needs a course of antibiotics to get better.

“Most of the infections that generate lots of phlegm and snot are viral illnesses and will get better on their own although you can expect to feel pretty poorly for a few weeks.

“The problems of antibiotic resistance are growing. Everyone can help by not using antibiotics for the treatment of uncomplicated infections.”

Taking antibiotics affects the trillions of bacteria that naturally live in the human body and can lead to resistance.

Dr Maureen Baker, chairwoman of the Royal College of GPs, said: “Overuse of antibiotics is a serious public health concern.

“Infections adapt to antibiotics used to kill them and can ultimately make treatment ineffective so it’s crucial that antibiotics are used appropriately.”

The green colour in phlegm and snot is the result of a protein made by the immune system to fight infection.

The latest advice comes on European Antibiotics Awareness Day.

Tylenol Just Once A Month Raises A Child’s Asthma Risk 540%.


The vast majority of babies are given Tylenol (acetaminophen) within the first six months of life. It is the go to medicine for modern parents whenever discomfort or fever strikes even very young children and its use is frequently encouraged by many pediatricians.

I

Now, a major study of over 20,000 children suggests that giving this popular medicine even as infrequently as once per year could have a permanent, life-threatening health effect.

Researchers at the University of A Coruna in Spain asked the parents of 10,371 children ages 6-7 and 10,372 adolescents aged 13-14 whether their children had asthma and how often they had been given acetaminophen within the previous year and when they were babies.
The children in the younger age group who had received the medicine only once per year were at 70% greater risk for asthma while those receiving Tylenol once a month or more were shockingly 540% more likely to have asthma.

The study, published in the European Journal of Public Health, also found that children who had even a single dose of Tylenol before their first birthday had a 60% risk of developing asthma.

In the older age group of 13 and 14 year-olds, asthma was 40 percent more likely if they had taken acetaminophen within the previous 12 months. The young teenagers were 250% more at risk if they took it once a month.

The researchers speculated that Tylenol, called paracetamol in the UK, may reduce a potent antioxidant called glutathione in the lungs and blood, which results in damage to the lung tissue. Glutathione is produced by the body (it is a combination of three amino acids:  cysteine, glycine and glutamine) and is referred to as the “mother” of all antioxidants by Dr. Mark Hyman MD.
While Tylenol use is strongly associated with a significant increase in asthma and the effect is greater the more often the drug is taken, no causal link is yet established via randomized-controlled trials. Does this mean the results of this large study should be dismissed and parents should continue favoring use of the popular over the counter medication for fever and pain?
Not so fast.

It would certainly be the wise and cautious approach for parents to investigate alternatives to Tylenol while additional follow-up research is performed.

Asthma rates have been on the increase for decades at the same time Tylenol use became more widespread. The potential link cannot and should not be ignored.

Examination of 20,000 children establishing such a strong associative risk must be taken seriously and the dismissal of the research by some doctors is irresponsible given the seriousness and life altering outcome of an asthma diagnosis.

The Effects of Fluoride on the Thyroid Gland


There is a daunting amount of research studies showing that the widely acclaimed benefits on fluoride dental health are more imagined than real. My main concern however, is the effect of sustained fluoride intake on general health. Again, there is a huge body of research literature on this subject, freely available and in the public domain.

But this body of work was not considered by the York Review when their remit was changed from “Studies of the effects of fluoride on health” to “Studies on the effects of fluoridated water on health.” It is clearly evident that it was not considered by the BMA (Britsh Medical Association), British Dental Association (BDA), BFS (British Fluoridation Society) and FPHM, (Faculty for Public Health and Medicine) since they all insist, as in the briefing paper to Members of Parliament – that fluoridation is safe and non-injurious to health.

This is a public disgrace, I will now show by reviewing the damaging effects of fluoridation, with special reference to thyroid illness.

It has been known since the latter part of the 19th century that certain communities, notably in Argentina, India and Turkey were chronically ill, with premature ageing, arthritis, mental retardation, and infertility; and high levels of natural fluorides in the water were responsible. Not only was it clear that the fluoride was having a general effect on the health of the community, but in the early 1920s Goldemberg, working in Argentina showed that fluoride was displacing iodine; thus compounding the damage and rendering the community also hypothyroid from iodine deficiency.

Highly damaging to the thyroid gland

This was the basis of the research in the 1930s of May, Litzka, Gorlitzer von Mundy, who used fluoride preparations to treat over-active thyroid illness. Their patients either drank fluoridated water, swallowed fluoride pills or were bathed in fluoridated bath water; and their thyroid function was as a result, greatly depressed. The use in 1937 of fluorotyrosine for this purpose showed how effective this treatment was; but the effectiveness was difficult to predict and many patients suffered total thyroid loss. So it was given a new role and received a new name, Pardinon. It was marketed not for over-active thyroid disease but as a pesticide. (Note the manufacturer of fluorotyrosine was IG Farben who also made sarin, a gas used in World War II).

This bit of history illustrates the fact that fluorides are dangerous in general and in particular highly damaging to the thyroid gland, a matter to which I shall return shortly. While it is unlikely that it will be disputed that fluorides are toxic – let us be reminded that they are Schedule 2 Poisons under the Poisons Act 1972, the matter in dispute is the level of toxicity attributable to given amounts; in today’s context the degree of damage caused by given concentrations in the water supply. While admitting its toxicity, proponents rely on the fact that it is diluted and therefore, it is claimed, unlikely to have deleterious effects.

They could not be more mistaken

It seems to me that we must be aware of how fluoride does its damage. It is an enzyme poison. Enzymes are complex protein compounds that vastly speed up biological chemical reactions while themselves remaining unchanged. As we speak, there occurs in all of us a vast multitude of these reactions to maintain life and produce the energy to sustain it. The chains of amino acids that make up these complex proteins are linked by simple compounds called amides; and it is with these that fluorine molecules react, splitting and distorting them, thus damaging the enzymes and their activity. Let it be said at once, this effect can occur at extraordinary low concentrations; even lower than the one part per million which is the dilution proposed for fluoridation in our water supply.

The body can only eliminate half

Moreover, fluorides are cumulative and build up steadily with ingestion of fluoride from all sources, which include not just water but the air we breathe and the food we eat. The use of fluoride toothpaste in dental hygiene and the coating of teeth are further sources of substantial levels of fluoride intake. The body can only eliminate half of the total intake, which means that the older you are the more fluoride will have accumulated in your body. Inevitably this means the ageing population is particularly targeted. And even worse for the very young there is a major element of risk in baby formula made with fluoridated water. The extreme sensitivity of the very young to fluoride toxicity makes this unacceptable. Since there are so many sources of fluoride in our everyday living, it will prove impossible to maintain an average level of 1ppm as is suggested.

What is the result of these toxic effects?

First the immune system. The distortion of protein structure causes the immune proteins to fail to recognise body proteins, and so instigate an attack on them, which is Autoimmune Disease. Autoimmune diseases constitute a body of disease processes troubling many thousands of people: Rheumatoid Arthritis, Systemic Lupus Erythematosis, Asthma and Systemic Sclerosis are examples; but in my particular context today, thyroid antibodies will be produced which will cause Thyroiditis resulting in the common hypothyroid disease, Hashimoto’s Disease and the hyperthyroidism of Graves’ Disease.

Musculo Skeletal damage results further from the enzyme toxic effect; the collagen tissue of which muscles, tendons, ligaments and bones are made, is damaged. Rheumatoid illness, osteoporosis and deformation of bones inevitably follow. This toxic effect extends to the ameloblasts making tooth enamel, which is consequently weakened and then made brittle; and its visible appearance is, of course, dental fluorosis.

The enzyme poison effect extends to our genes; DNA cannot repair itself, and chromosomes are damaged. Work at the University of Missouri showed genital damage, targeting ovaries and testes. Also affected is inter uterine growth and development of the foetus, especially the nervous system. Increased incidence of Down’s Syndrome has been documented.

Fluorides are mutagenic. That is, they can cause the uncontrolled proliferation of cells we call cancer. This applies to cancer anywhere in the body; but bones are particularly picked out. The incidence of osteosarcoma in a study reporting in 1991 showed an unbelievable 50% increase. A report in 1955 in the New England Journal of Medicine showed a 400% increase in cancer of the thyroid in San Francisco during the period their water was fluoridated.

My particular concern is the effect of fluorides on the thyroid gland

Perhaps I may remind you about thyroid disease. The thyroid gland produces hormones which control our metabolism – the rate at which we burn our fuel. Deficiency is relatively common, much more than is generally accepted by many medical authorities: a figure of 1:4 or 1:3 by mid life is more likely. The illness is insidious in its onset and progression. People become tired, cold, overweight, depressed, constipated; they suffer arthritis, hair loss, infertility, atherosclerosis and chronic illness. Sadly, it is poorly diagnosed and poorly managed by very many doctors in this country.

What concerns me so deeply is that in concentrations as low as 1ppm, fluorides damage the thyroid system on 4 levels.

1. The enzyme manufacture of thyroid hormones within the thyroid gland itself. The process by which iodine is attached to the amino acid tyrosine and converted to the two significant thyroid hormones, thyroxine (T4) and liothyronine (T3), is slowed.

2. The stimulation of certain G proteins from the toxic effect of fluoride (whose function is to govern uptake of substances into each of the cells of the body), has the effect of switching off the uptake into the cell of the active thyroid hormone.

3. The thyroid control mechanism is compromised. The thyroid stimulating hormone output from the pituitary gland is inhibited by fluoride, thus reducing thyroid output of thyroid hormones.

4. Fluoride competes for the receptor sites on the thyroid gland which respond to the thyroid stimulating hormone; so that less of this hormone reaches the thyroid gland and so less thyroid hormone is manufactured.

These damaging effects, all of which occur with small concentrations of fluoride, have obvious and easily identifiable effects on thyroid status. The running down of thyroid hormone means a slow slide into hypothyroidism. Already the incidence of hypothyroidism is increasing as a result of other environmental toxins and pollutions together with wide spread nutritional deficiencies.

141 million Europeans are at risk

One further factor should give us deep anxiety. Professor Hume of Dundee, in his paper given earlier this year to the Novartis Foundation, pointed out that iodine deficiency is growing worldwide. There are 141 million Europeans are at risk; only 5 European countries are iodine sufficient. UK now falls into the marginal and focal category. Professor Hume recently produced figures to show that 40% of pregnant women in the Tayside region of Scotland were deficient by at least half of the iodine required for a normal pregnancy. A relatively high level of missing, decayed, filled teeth was noted in this non-fluoridated area, suggesting that the iodine deficiency was causing early hypothyroidism which interferes with the health of teeth. Dare one speculate on the result of now fluoridating the water?

Displaces iodine in the body

These figures would be worrying enough, since they mean that iodine deficiency, which results in hypothyroidism (thyroid hormone cannot be manufactured without iodine) is likely to affect huge numbers of people. What makes it infinitely worse, is that fluorine, being a halogen (chemically related to iodine), but very much more active, displaces iodine. So that the uptake of iodine is compromised by the ejection, as it were, of the iodine by fluorine. To condemn the entire population, already having marginal levels of iodine, to inevitable progressive failure of their thyroid system by fluoridating the water, borders on criminal lunacy.

I would like to place a scenario in front of those colleagues who favour fluoridation. A new pill is marketed. Some trials not all together satisfactory, nevertheless, show a striking improvement in dental caries. Unfortunately, it has been found to be thyrotoxic, mutagenic, immunosuppressive, cause arthritis and infertility in comparatively small doses over a relatively short period of time.

Do you think it should be marketed?

Fluoridation of the nation’s water supply will do little for our dental health; but will have catastrophic effects on our general health. We cannot, must not, dare not, subject our nation to this appalling risk.

References:

L Goldemberg – La Semana Med 28:628 (1921) – cited in Wilson RH, DeEds F -“The Synergistic Action Of Thyroid On Fluoride Toxicity” Endocrinology 26:851 (1940).
G Litzka – “Die experimentellen Grundlagen der Behandlung des Morbus Basedow und der Hyperthyreose mittels Fluortyrosin” Med Wochenschr 63:1037-1040 (1937) (discusses the basis of the use of fluorides in anti-thyroid medication, documents activity on liver, inhibition of glycolysis, etc.).

W May – “Behandlung der Hypothyreosen einschlieblich des schweren genuinen Morbus Basedow mit Fluor” Klin Wochenschr 16: 562 – 564 (1937).

Sarin: (GB: isopropyl methylphosono-fluoridate) is a colorless, odorless volatile liquid, soluble in water, first synthesized at IG Farben in 1938. It kills mainly through inhalation.

Cyclosarin (GF) and Thiosarin are variants. Pennsylvania Department of Healthdsf.health.state.pa.us/health/cwp/view.asp?a=171&q=233740

Sarin: (GB: CH3-P(=O)(-F)(-OCH(CH3)2)
Source: A FOA Briefing Book on Chemical Weapons opcw.org/resp/html/nerve.htmlGerhard Schrader, a chemist at IG Farben, was given the task of developing a pesticide. Two years later a phosphorus compound with extremely high toxicity was produced for the first time. IG Farben: “…the board of American IG Farben had three directors from the Federal Reserve Bank of New York, the most influential of the various Federal Reserve Banks. American IG Farben. also had interlocks with Standard Oil of New Jersey, Ford Motor Company, Bank of Manhattan (later to become the Chase Manhattan Bank), and AEG. (German General Electric) Source: Moody’s Manual of Investments; 1930, page 2149.”

Source: oawhealth.com

         

Europeans consume far less sugar than Americans, and yet health officials there recognize a growing health epidemic.


If you have ever visited Europe, then you may recall that most of the foods produced and sold there are generally far less sweet than foods produced and sold in the U.S. And yet, despite this difference, Van der Velpen still sees a major public health epidemic brewing in his country as a result of sugar consumption — how much worse must the situation be here in the U.S., where public health officials generally avoid tagging sugar as a major factor in declining public health?
“Sugar is actually a form of addiction,” adds Van der Velpen. “It’s just as hard to get rid of the urge for sweet foods as of smoking. Thereby diets only work temporarily. Addiction therapy is better … Health insurers should have to finance addiction therapy for their obese clients.”

It is important to note that Amsterdam has long tolerated the presence and use of other typically restricted substances such as cannabis, a plant that government authorities the world over have long referred to as a “drug,” within its borders. Cannabis, of course, does not harm the body and is not a public health threat, thus Amsterdam’s relaxed approach to its availability within the city. Sugar, on the other hand, is an actual threat, and Van der Velpen hopes others will learn this truth and take action.

Sources
http://www.telegraph.co.uk

Sugar named ‘most addictive and dangerous substance’ of our time, worse than cigarettes and alcohol.


While the rest of the world is busy obsessing over the dangers of cigarettes and alcohol, the head of Amsterdam‘s health service in the Netherlands is trying to raise awareness about a much bigger and more pervasive health threat: sugar. According to Paul Van der Velpen, sugar is the most dangerous and addictive substance of modern times, and more needs to be done in the interests of public health to make people aware of the many harms caused by this ubiquitous drug.

Sugar-Cubes

In a recent letter posted by GGD Nederland, an association of the country’s community health services, Van der Velpen discusses the issue of obesity, rates of which have risen dramatically in the Netherlands in recent years. Pointing out that obesity, which is linked to metabolic syndrome, cardiovascular disease and a host of other chronic ailments, saps the healthcare system of tens of millions of dollars annually, Van der Velpen emphasizes that exercise is simply not enough to reverse this growing trend.

Bravely defying processed food industry claims, which insist that sugar consumed “in moderation” is just fine, Van der Velpen delves into the actual science behind how the body responds to sugar as opposed to protein and fat. In his letter, Van der Velpen explains that sugar intensifies food cravings, for instance, and causes people to eat far more than they otherwise would without it. Additionally, he points out that sugar also disrupts normal food metabolism, eventually leading to addiction.

“Just like alcohol and tobacco, sugar is actually a drug,” writes Van der Velpen, in an English translation from the original Dutch. “This may seem exaggerated and far-fetched, but sugar is the most dangerous drug of the times and can still be easily acquired everywhere … The use of sugar should be discouraged. And users should be made aware of the dangers.”

%d bloggers like this: