This Popular Ketchup Damages Your, Liver, Metabolism, Immune System, Nervous System and Brain


Many of you are not aware of the method of labeling ingredients in food products. Namely, companies list the ingredients according to the amounts added to the food, from the most to the least.

 This is important as it gives you an opportunity to control what you consume.

When it comes to Heinz ketchup, we strongly advise you to stay away from it, and we give the most important reasons:

High Fructose Corn Syrup

Heinz ketchup is loaded with high fructose corn syrup, and this would have been evident if the company did not list the same ingredients twice under a different name, corn syrup, and high fructose corn syrup.

This ingredient acts as sugar in the body when metabolized, and raises the blood sugar levels, and endangers the functioning of the liver. It is derived from GMO and causes obesity, weight gain, heart diseases, diabetes, and weakened immune system.

Distilled Vinegar and Sugar

Despite the high fructose corn syrup, they have also added additional sugar- even 4 extra grams of sugar per tablespoon!

In the end, they add distilled vinegar, which is another GMO corn ingredient.

Therefore, this product contains three GMO ingredients, sugar, chemicals, and actually no place for any nutrients! Does this sound healthy, does it actually sound like a food?

The list of ingredients continues with additives, salt, onion powder, no fiber, no protein, and no nutritional value.

Therefore, we advise you to never consume this ketchup again!

Source: healinglifeisnatural.com

Nerve cells actively repress alternative cell fates, researchers find


A neural cell maintains its identity by actively suppressing the expression of genes associated with non-neuronal cell types, including skin, heart, lung, cartilage and liver, according to a study by researchers at the Stanford University School of Medicine.

 It does so with a powerful . “When this protein is missing, neural cells get a little confused,” said Marius Wernig, MD, associate professor of pathology. “They become less efficient at transmitting nerve signals and begin to express genes associated with other cell fates.”

The study marks the first identification of a near-global repressor that works to block many cell fates but one. It also suggests the possibility of a network of as-yet-unidentified master regulators specific to each cell type in the body.

“The concept of an inverse master regulator, one that represses many different developmental programs rather than activating a single program, is a unique way to control neuronal cell identity, and a completely new paradigm as to how cells maintain their throughout an organism’s lifetime,” Wernig said.

Because the protein, Myt1l, has been found to be mutated in people with autism, schizophrenia and major depression, the discovered mode of action may provide new opportunities for therapeutic intervention for these conditions, the researchers said.

Wernig is the senior author of the study, which will be published online April 5 in Nature. Postdoctoral scholars Moritz Mall, PhD, and Michael Kareta, PhD, are the lead authors.

Repressors

Myt1l is not the only protein known to repress certain cell fates. But most other known repressors specifically block only one type of developmental program, rather than many. For example, a well-known repressor called REST is known to block the neuronal pathway, but no others.

“Until now, researchers have focused only on identifying these types of single-lineage repressors,” said Wernig. “The concept of an ‘everything but’ repressor is entirely new.”

In 2010, Wernig showed that it is possible to convert skin into functional neurons over the course of three weeks by exposing them to a combination of just three proteins that are typically expressed in neurons. This “direct reprogramming” bypassed a step called induced pluripotency that many scientists had thought was necessary to transform one cell type into another.

 One of the proteins necessary to accomplish the transformation of skin to neurons was Myt1l. But until this study the researchers were unaware precisely how it functioned.

“Usually we think in terms about what regulatory programs need to be activated to direct a cell to a specific developmental state,” said Wernig. “So we were surprised when we took a closer look and saw that Myt1l was actually suppressing the expression of many genes.”

These genes, the researchers found, encoded proteins important for the development of lung, heart, liver, cartilage and other types of non-neuronal tissue. Furthermore, two of the proteins, Notch and Wnt, are known to actively block neurogenesis in the developing brain.

Blocking Myt1l expression in the brains of embryonic mice reduced the number of mature neurons that developed in the animals. Furthermore, knocking down Myt1l expression in mature neurons caused them to express lower-than-normal levels of neural-specific genes and to fire less readily in response to an electrical pulse.

‘A perfect team’

Wernig and his colleagues contrasted the effect of Myt1l with that of another protein called Ascl1, which is required to directly reprogram skin fibroblasts into neurons. Ascl1 is known to specifically induce the expression of neuronal genes in the fibroblasts.

“Together, these proteins work as a perfect team to funnel a developing cell, or a cell that is being reprogrammed, into the desired cell fate,” said Wernig. “It’s a beautiful scenario that both blocks the fibroblast program and promotes the neuronal program. My gut feeling would be that there are many more master repressors like Myt1l to be found for specific cell types, each of which would block all but one cell fate.”

Source:medicalxpress.com

Pesticides Found in Your Food Linked to Diabetes, Liver, Kidney and Brain Disease


Pesticides Found in Your Food Linked to Diabetes, Liver, Kidney and Brain Disease

 Long-term exposure to pesticides has been linked to infertility, birth defects, endocrine disruption, neurological disorders and cancer, so it’s a common-sense conclusion that fewer pesticides in our food supply would result in improved health among the general population.

In fact, one of the strongest selling points for eating organic food is that it can significantly lower your exposure to pesticides and other harmful chemicals used in conventional agriculture, and this measure in and of itself may help protect your long-term health and/or improve any health conditions you may have.

Since organic standards prohibit the use of synthetic pesticides and herbicides, organic foods are, as a rule, less contaminated, and studies have confirmed that those who eat a primarily organic diet have fewer toxins in their system.

Sadly, the chemical technology industry wields great power — so great that our government has largely turned a blind eye to the obvious, which is that too many toxic chemicals, in too great amounts, are being allowed in the growing of food. As noted in the featured film, “From DDT to Glyphosate:”

“Just as was the case in the 1950s with DDT and tobacco, we are on the brink of disastrous damage to health worldwide. This short film begins to explain why, and what we can do.”

Help Educate Those You Love

“From DDT to Glyphosate” is just half an hour long, yet it’s an excellent introduction to the dangers of pesticides.

The ‘Silent Spring’ Continues

In 1962, American biologist Rachel Carson wrote the groundbreaking book “Silent Spring,” in which she warned of the devastating environmental impacts of DDT (dichloro-diphenyl-trichloroethane), suggesting the chemical may also have harmful effects on human health.

She rightfully questioned the logic and sanity of using such vast amounts of a chemical without knowing much about its ecological and human health impact.

Her book triggered a revolution in thinking that gave birth to the modern environmental movement, and the public outcry that resulted from her book eventually led to DDT being banned for agricultural use in the U.S. in 1972.

Unfortunately, DDT was simply replaced with other equally unsafe and untested chemicals. Today, we’re also exposed to even vaster amounts of pesticides, and a wider variety of them, which is why it’s so important to share the above film with as many people as possible.

Consider this: the very same companies that developed chemical warfare weapons during World War II simply transitioned into agriculture after the war, and many of the same warfare chemicals are now sprayed on our food.

The notion that these chemicals are good for humans, the environment and the business of agriculture is a fabricated one.

Genetic Engineering Fuels the Chemical Agriculture Engine

As noted in the film, 80 percent of genetically engineered (GE) crops are designed to withstand herbicide application; most often glyphosate-based herbicides, such as Monsanto’s Roundup. As a result, we’re ingesting far greater quantities of pesticides than ever before.

The question is, where’s the breaking point? There’s reason to believe we may have crossed the threshold already. Health statistics suggest the average toxic burden has become too great for children and adults alike, and toxins in our food appear to play a primary role.

According to Dr. Joseph E. Pizzorno, founding president of Bastyr University, the first fully accredited multidisciplinary university of natural medicine and the first National Institutes of Health-funded center for alternative medicine research, toxins in the modern food supply are now “a major contributor to, and in some cases the cause of, virtually all chronic diseases.”

Watch the video. URL:https://youtu.be/mF2iS5vIamg

8 Foods To CLEAN Your Liver


8 Cleansing Spring Foods To Support Your Liver Hero Image

8 Cleansing Spring Foods To Support Your Liver Hero Image

There’s a reason that asparagus is the celebrated veggie of spring. Yes, it is one of the first vegetables to make itself known in the garden, but that’s not the only thing to get excited about.

Asparagus, along with a few other foods, gives our body the boost in needs to recover from the chill of winter. Spring is a natural time to think about hitting the dietary reset button.

There is no right way to spring clean your diet, you just need to pick a starting point. Choose foods that support your body’s natural detoxification process and that fuel your life force—your prana or chi.

Foods that purify your system include colorful veggies and fruits that are antioxidant rich. Phytochemicals in plants absorb sunlight giving them their rich colors and vibrant flavors. When we eat these foods the energy is transferred to us.

Try to add one or two more servings to your day, or add a new color or vegetable that you haven’t tried. Some ideal veggies include:

1. Asparagus

Asparagus contains glutathione, a powerful antioxidant known for its role in supporting the body’s naturaldetoxification process carried out by your liver.

Asparagus cooks very quickly, making it an easy addition to an omelet in the morning. What’s better than starting your day with a fresh green veggie?

2. Avocados

Along with asparagus, avocados are rich in glutathione. This powerful antioxidant supports the liver in getting rid of harmful materials.

Avocados are a fun addition to a smoothie—hello, yummy creamy beverage.

3. Lemons

The volatile oils in the rind of the lemon are called limonoids. These chemicals, in addition to the juice of the lemon, support healthy digestion.

Lemons are also abundant in vitamin C, which boosts your immune system while fighting free radical damage to the body.

Squeeze a little in your water, or, better yet, make your own zesty salad dressing. My favorite is lemon tahini, which is great drizzled on kale, broccoli, or just about any other veggie you can think of.

4. Walnuts

High in ALA (alpha-linolenic acid), a type of omega-3 fat that not onlyboosts brain power and also supports detoxification in the body.

You know what to do here: Toss some on a salad or just enjoy them as a snack.

5. Garlic

Raw garlic, in particular, activates liver enzymes, helping your body to destroy unwanted chemicals and toxins.
Mince or chop fresh garlic, let it sit on the counter for a minute or two (this activates the allicin, the enzyme that gives it its aroma), and then add it to salad dressing or a really nice olive oil for dipping vegetables or crusty bread.

6. Dandelion

Yes, the pesky lawn weed has medicinal properties. The root of dandelion makes a great tea that has been shown to help the liver rid the body of toxins.

The tea is a tad bitter, so add a splash of local honey.

7. Beets

It’s acceptable to continue eating these root veggies well into spring. Beets benefit the overall health of the liver while also boosting cardiovascular endurance.

Roast, juice, or shred them on a salad.

8. Green Tea

Nothing says spring better than iced tea. Why not make it iced green tea? Green tea is high in catechins, which cleanse the body and support liver health.

Add a bit of mint for a refreshing twist.

Spring is a natural time of transition. No matter where you may have drifted over the winter, don’t let that stop you. As we now head into the vibrancy of spring, start thinking about what your reset looks like. Keep a growth mindset over the next few weeks.

This is not a pass-fail event but rather an invitation to transition your diet to one that supports your best self as you step into the warmth of spring. Pick one food each week to add to your cooking routine.

Liver plays role in pneumonia, sepsis susceptibility


New evidence highlights the importance of the liver in immunity against bacterial pneumonia. The study is the first of its kind to directly show such a link between liver-produced molecules and pneumonia susceptibility during sepsis.

Led by researchers at Boston University School of Medicine (BUSM), the study appears in the journal Infection and Immunity.

Pneumonia, according to the World Health Organization, is the leading infectious cause of death in children worldwide, taking more than 900,000 lives of children under the age of 5 in 2013 alone. Pneumonia, in both children and adults, is frequently associated with , which is the body’s own inflammatory reaction to becoming infected.

In order to model the common clinical scenario of sepsis followed by , models were systemically treated with a bacterial product (eliciting a sepsis-like response) followed hours later by a live bacterial challenge in the lungs. One group had completely normal livers, and the other lacked a gene in their livers that prevented maximal activation. The researcher found the group lacking a complete liver response was more likely to succumb to pneumonia, exhibiting a significantly compromised immune response in both the lungs and blood, where more bacteria survived.

According to the researchers there is a well-established link between pneumonia and sepsis, such that both increase the likelihood of the other. Both also activate the liver to initiate what is known as the acute phase response, an event leading to the liver’s production of acute phase proteins that change in the blood “These proteins are frequently used as clinical biomarkers, but their combined biological significance is mostly speculative. However, the results of this study directly suggest that liver activation is required to maintain adequate immune responses in the lungs,” explained corresponding author Lee J. Quinton, PhD, associate professor of medicine and pathology at BUSM.

While it may be too early to immediately speculate on the applications of these findings, the authors believe that liver activity may serve as a previously unappreciated window into pneumonia defense/susceptibility. “A better understanding of how these distinct organs collaborate to mount immune responses has important clinical implications for patients with or at risk for pneumonia and sepsis. The idea that non-lung tissue could be targeted for treatments of lung disease is compelling,” added Quinton.

“Good” Protein Actually Promotes Liver Cancer.


  • Scientists at the University of Iowa say they have identified an unexpected molecular link between liver cancer, cellular stress, and these health problems that increase the risk of developing this cancer. Their study (“The Stress-Regulated Transcription Factor CHOP Promotes Hepatic Inflammatory Gene Expression, Fibrosis, and Oncogenesis”) is published in PLOS Genetics. It shows that a protein called CHOP, which had previously been thought to generally protect against cancer, actually promotes liver cancer in mice and may do the same in humans.

    “Good” Protein Actually Promotes Liver Cancer

    “Obesity, alcoholism, and viral hepatitis are all known independently to cause cellular stress and to induce expression of CHOP,” said Thomas Rutkowski, Ph.D., assistant professor of anatomy and cell biology in the UI Carver College of Medicine and senior study author. “So this finding suggests a biological pathway that links those ‘upstream’ health problems to liver cancer at the end.”

    CHOP is a transcription factor that is produced when cells experience certain kinds of stress. It is known to promote cell death. Usually, factors that promote cell death protect against cancer by causing damaged cells to die.

    The study shows that, despite its role in cell death, CHOP actually is elevated in liver tumor cells in mice. Furthermore, mice without CHOP are partially protected from liver cancer, developing fewer and smaller tumors than the normal mice in response to liver cancer-causing drugs. The mice without CHOP also had less liver scarring and inflammation than mice with the protein.

    “We show that CHOP expression is up-regulated in liver tumors in human HCC [hepatocellular carcinoma] and two mouse models thereof. CHOP-null mice are resistant to chemical hepatocarcinogenesis, and these mice exhibit attenuation of both apoptosis and cellular proliferation,” wrote the investigators. “CHOP-null mice are also resistant to fibrosis, which is a key risk factor for HCC. Global gene expression profiling suggests that deletion of CHOP reduces the levels of basal inflammatory signaling in the liver. Our results are consistent with a model whereby CHOP contributes to hepatic carcinogenesis by promoting inflammation, fibrosis, cell death, and compensatory proliferation.”

    “We turned out to be completely wrong about CHOP. We found that it contributes to the development of liver cancer in mice and is associated with liver cancer in humans,” continued Dr. Rutkowski. “CHOP is indeed killing cells, just as we thought it would, but we think the consequence of this killing is not the prevention of tumors, but instead the stimulation of inflammatory signals in the liver that cause excessive proliferation of other cells.”

    Having implicated CHOP as a contributing factor in liver cancers associated with obesity, alcoholism, and hepatitis, Dr. Rutkowski next wants to learn whether CHOP acts early in the process of tumor formation or if it plays a role in helping established tumors to grow. He also is interested in identifying the other proteins that partner with CHOP to promote liver cancer.

    “This discovery opens up an avenue into a new pathway that promotes liver cancer,” explained Dr. Rutkowski. “Once we know what those other genes are that interact with CHOP, then maybe we can find a druggable target molecule. The hope is that down the line scientists will be able to convert that finding into something therapeutically useful for patients.”

USFDA approves breakthrough drug for hepatitis C.


The nod represents a significant shift in treatment paradigm

The U.S. has approved a breakthrough therapy for treatment of chronic hepatitis C that is expected to offer a more palatable cure to millions of people infected with the liver-destroying viral disease.

Approved by the Food and Drug Administration, the pill, Sovaldi (sofosbuvir) is the first drug that has demonstrated safety and efficacy to treat certain types of HCV infection without the need for co-administration of interferon, an official announcement said on Friday.

“Today’s (Friday’s) approval represents a significant shift in the treatment paradigm for some patients with chronic hepatitis C,” said Edward Cox, director of the Office of Antimicrobial Products in the FDA’s Center for Drug Evaluation and Research.

Sovaldi is the second drug approved by the FDA in the past two weeks to treat chronic HCV (hepatitis C virus) infection.

On November 22, the FDA had approved Olysio (simeprevir).

Sovaldi is marketed by Gilead, based in Foster City, California. Olysio is marketed by Raritan, New Jersey-based Janssen Pharmaceuticals.

Clinical trials

The FDA said Sovaldi’s effectiveness was evaluated in six clinical trials consisting of 1,947 participants, who had not previously received treatment for their disease (treatment-naive) or had not responded to previous treatment (treatment-experienced), including participants co-infected with HCV and HIV.

Hepatitis C is a viral disease that causes inflammation of the liver that can lead to diminished liver function or liver failure.

About 3.2 million Americans are infected with hepatitis C, according to the Centers for Disease Control and Prevention, the CNN said.

Symptoms

Symptoms may include fever, fatigue, loss of appetite, vomiting, nausea, abdominal pain, dark urine, clay—coloured bowel movements, joint pain and jaundice, according to the CDC.

The once-a-day pill is the first approved to treat certain types of hepatitis C infection without the need for interferon, an injected drug that can cause severe flu-like symptoms. Hepatitis C, which is often undiagnosed, affects about 3.2 million Americans, killing more than 15,000 each year, mostly from illnesses such as cirrhosis and liver cancer. Most patients will be treated with the $1,000-a-day drug for 12 weeks, resulting in a total list price of $84,000, according to Gilead spokeswoman Cara Miller.

Last year, the CDC recommended that all baby boomers, born from 1945 to 1965, be tested for the virus. Introduction of blood and organ screening in the 1990s has dramatically lowered infection rates for younger generations.

The Gilead drug’s approval was supported by several studies showing that it helped to eradicate the virus in significantly more patients, with fewer side effects, than the current drug regimen.

Sovaldi is the first in a new class of medications known as nucleotide analogue inhibitors, or “nukes,” designed to block a specific protein that the hepatitis C virus needs to copy itself.

Pump provides liver disease relief


pump diagram
The rechargeable pump sits underneath the skin and can be switched off at night

Patients at the Royal Free Hospital in London are testing a device that provides relief from a common side-effect of liver disease.

The pump siphons off excess fluid that can build up in the abdomen after liver failure and diverts it to the bladder so it can be urinated out.

A liver transplant may be the only option for patients with cirrhosis.

Doctors say the pump could buy time and may even allow the liver to recover, avoiding the need for a transplant.

“Start Quote

It can improve quality of life for patients and keep them out of hospital for longer”

Prof Rajiv Jalan

So far eight patients at the Royal Free have had one fitted.

The Alphapump sits beneath the skin of the abdomen and is connected to two small tubes that do the siphoning.

Ascites

When patients have cirrhosis, the liver and kidneys stop working properly and fluid, known as ascites, can accumulate.

Litres of fluid can gather inside the abdominal cavity, making the patient appear pregnant as well as being painful.

Patients may have to make weekly or monthly trips to hospital to have the fluid drained.

Rajiv Jalan, professor of hepatology at University College London’s institute for liver and digestive health at the Royal Free, is the doctor running the trial.

He said: “With cirrhosis, patients can accumulate litres and litres of fluid. They might need to come to hospital fortnightly to have up to 20 litres drained from their tummy.

“The pump can avoid this by draining about 15 millilitres every 15 minutes. It means they’ll pass a little bit more urine but they can turn the pump off at night.

“It can improve quality of life for patients and keep them out of hospital for longer.”

Hepatic resection combined with radiofrequency ablation for initially unresectable colorectal liver metastases after effective chemotherapy is a safe procedure with a low incidence of local recurrence.


Abstract

Background

Chemotherapy can lead to tumor down-staging in patients with initially unresectable colorectal liver metastases (CRLM); however, more than half of such cases are still considered to be unresectable because of disease progression, including multiple or bilobar CRLM, and an insufficient predicted remnant liver volume. In addition, there is little evidence supporting the use of radiofrequency ablation (RFA) for patients with CRLM. This study compared the safety and efficacy of hepatic resection (HR) combined with RFA versus HR alone after effective chemotherapy in patients with initially unresectable CRLM.

Methods

Data were prospectively collected on 118 consecutive patients with initially unresectable CRLM who received FOLFOX ± bevacizumab as the first-line chemotherapy. 48 of these patients (41 %) underwent HR or HR + RFA after the chemotherapy. HR was performed in 35 patients (HR group), and HR + RFA in 13 (HR + RFA group).

Results

There was no mortality in either group. Postoperative morbidity rates in the HR group and the HR + RFA group were 17 and 23 %, respectively (P = 0.640). Local recurrence at the RFA site occurred in only one tumor (1.6 % per lesion, 7.7 % per patients). The 3-year progression-free survival was 45.3 % in the HR group and 12.8 % in the HR + RFA group (P = 0.472). The 3-year overall survival rate was 70.4 % in the HR group and 77.1 % in the HR + RFA group (P = 0.627).

Conclusions

These results suggest that HR + RFA after effective chemotherapy is a safe procedure with low local recurrence at the RFA site and is a potentially effective treatment option for patients with initially unresectable CRLM.

Source: International Journal of Clinical Oncology

More children are suffering from fatty liver disease.


DEAR MAYO CLINIC: I recently read that fatty liver disease is becoming common in young children. What’s the cause of this condition? How is it diagnosed, and can it be reversed?

ANSWER: The number of children who have fatty liver disease is rising. Currently, about 10 percent of children in the U.S. have this disease. It is the most common cause of childhood chronic liver disease in this country. The increase is linked to the childhood obesity epidemic, as fatty liver disease is often caused by excessive weight gain. If it is caught and treated early, the disease typically can be reversed through lifestyle changes, including diet and exercise.

The liver is one of the largest organs in the body. About the size of a football, it is located on the right side of the abdomen, behind the lower ribs. Fatty liver disease (also called nonalcoholic fatty liver disease) occurs when fat builds up in the liver of people who drink little or no alcohol.
Typically the disease causes few, if any, symptoms. Many people with fatty liver disease have it for years and don’t know it. It is important for the disease to be diagnosed, however. If left unchecked, it could eventually lead to liver function problems, especially in children.

The most common cause of fatty liver disease in children is obesity. In children who are at a healthy body weight, fatty liver disease can also be the result of rare metabolic disorders, such as Wilson’s disease or cystic fibrosis, among others.

A doctor may suspect fatty liver disease if a blood test shows that a child’s level of liver enzymes is higher than normal, especially if the child is overweight. The disease also may be discovered through an imaging exam, such as an ultrasound. A diagnosis of fatty liver disease can be confirmed by microscopic examination of a small sample of tissue removed from the liver, a procedure known as a liver biopsy.

If caught while still in the early stages, fatty liver disease may be reversible. In children who are overweight, weight loss often is key to treating the disease. Weight loss usually is best accomplished with a combination of a healthy diet and regular physical activity.

In general, there are some strategies all families can use to help children reach and maintain a healthy weight. For example, make sure you have lots of healthy food choices available in your home. Buy plenty of fruits and vegetables. Cut down on convenience foods, such as cookies, crackers and prepared meals that are high in sugar and fat. Limit sweetened beverages, including fruit juices. These drinks are high in calories and low in nutritional value. They also can make a child feel too full to eat healthier foods.

Encourage your child to be physically active. This not only helps with weight loss, but also builds strong bones and muscles and helps a child sleep better at night. Keep in mind that activity does not have to be structured exercise to burn calories and improve fitness. Playing outdoors, jumping rope and going for hikes can all be good ways for a child to be active.

It is very important that children and teens avoid using supplements to help with weight loss or building muscle. Some of these supplements have recently been associated with acute liver failure and other dangerous health outcomes.

Don’t start a child on a specific weight-loss program before talking with his or her health care provider. It’s important that a weight-loss approach be tailored to a child’s individual situation and needs, including the child’s age and if he or she has any other health problems. — Samar Ibrahim, M.B., Ch.B., Pediatric Gastroenterology, Mayo Clinic, Rochester, Minn.