Multivariate analysis of the data showed that the only variable linked to type 1 diabetes or autoislet immunity was having a first-degree relative with type 1 diabetes ( <.001). After adjustment for this factor, researchers found no significant association between development of type 1 diabetes and full breast-feeding (OR=1.28; =.66) or any breast-feeding (OR=1.01; =.99). Similar results were noted for full breast-feeding (OR=1.3; =.41) or any breast-feeding (OR=1.25; =.51) and islet autoimmunity.
For the study, the researchers assessed data from the MIDIA prospective cohort study, which included children with the high-risk human leukocyte antigen (HLA) genotype. Of 48,000 children genotyped, 1,047 had the high-risk HLA genotype. At 3, 6, 9 and 12 months of age, parents filled out questionnaires and the researchers obtained blood samples from the children. Full and any breast-feeding were defined using WHO criteria, and logistic regression analyses were used to identify the relationship between type 1 diabetes and islet autoimmunity and full or any breast-feeding and parent or infant characteristics.
Source: Endocrine Today.