Hormone therapy with estrogen-based regimens does not affect long-term cognitive function when prescribed to younger postmenopausal women, according to an analysis from the Women’s Health Initiative, published inJAMA Internal Medicine.
Researchers studied some 1300 women who, between ages 50 and 55, were randomized to estrogen-based hormone therapy or placebo. Treatment lasted roughly 7 years, and cognitive tests were performed about 7 years after treatment ended. Overall, cognitive scores did not differ significantly between active treatment and placebo, a finding that held true for estrogen combined with medroxyprogesterone acetate and for estrogen alone.
The authors conclude: “Our findings provide reassurance that [estrogen]-based therapies when administered to women earlier in the postmenopausal period do not seem to convey long-term adverse consequences for cognitive function.”
Source: JAMA
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