British scientists have discovered a potential cause for multiple sclerosis, in a major breakthrough that could pave the way for new treatments for the disease.
Scientists have found a new cellular mechanism which may cause the autoimmune disorder. Multiple sclerosis affects around 2.5 million people around the world.
Typically, people are diagnosed in their 20s and 30s, and it is more common in women than men.
Although the cause has so far been a mystery, the disease causes the body’s own immune system to attack myelin – the fatty “sheaths” which protect nerves in the brain and spinal cord.
This leads to brain damage, a reduction in blood supply and oxygen and the formation of lesions in the body.
Symptoms can be wide-ranging, and can include muscle spasms, mobility problems, pain, fatigue, and problems with speech.
Scientists have long suspected that mitochondria, the energy-creating “powerhouse” of the cell, plays a link in causing multiple sclerosis.
Using human brain tissue samples, researchers at the Universities of Exeter and Alberta found a protein called Rab32 is present in large quantities in the brains of people with MS – but is virtually absent in healthy brain cells.
Where Rab32 is present, the team discovered that a part of the cell which stores calcium gets too close to the mitochondria.
The resulting miscommunication with the calcium supply triggers the mitochondria to misbehave, ultimately causing toxicity for brain cells in people with MS.
Researchers do not yet know what causes an unwelcome influx of Rab32 but they believe the defect could originate at the base of the cell.
The finding will enable scientists to search for effective treatments that target Rab32 and embark on determining whether there are other proteins which could play a role in triggering MS.
“So far, all medicine can offer is treatment and therapy for the symptoms – as we do not yet know the precise causes, research has been limited.
“Our exciting new findings have uncovered a new avenue for researchers to explore. It is a critical step, and in time, we hope it might lead to effective new treatments for MS.”
The research has been published as part of MS Awareness Week. Dr David Schley, from the MS Society, said: “No-one knows for sure why people develop MS and we welcome any research that increases our understanding of how to stop it.
“There are currently no treatments available for many of the more than 100,000 people in the UK who live with this challenging and unpredictable condition.
“We want people with MS to have a range of treatments to choose from, and be able to get the right treatment at the right time.”
Trish Deykin, who suffers from MS, welcomed the research.
She said: “Finding a cause will help everyone who has MS – even if that’s just knowing more about what’s going on in their own brains.”
The paper, Rab32 connects ER stress to mitochondrial defects in multiple sclerosis, is published in the journal Neuroinflammation.