The more researchers learn about the Zika virus, the worse it seems.
A growing body of research has established that the virus can cause severe birth defects — most notably microcephaly, a condition characterized by an abnormally small head and often incomplete brain development. The virus also has been linked to cases of Guillain-Barré syndrome in adults, a rare autoimmune disorder that can result in paralysis and even death.
“This was kind of a surprise,” Joseph Gleeson, a professor at Rockefeller University and one of the authors of the study published Thursday in the journal Cell Stem Cell, said in an interview. “We think of Zika health concerns being limited mostly to pregnant women.”
But some neural progenitor cells remain in adults, where they replenish the brain’s neurons over a lifetime. These pockets of stem cells are vital for learning and memory. Gleeson and his colleagues suspected that if Zika can infect fetal neural progenitor cells, the virus might have the same ability to infect adult neural progenitor cells. That’s precisely what they found.
“We asked whether [these cells] were vulnerable to Zika in the same way the fetal brain is,” Glesson said. “The answer is definitely yes.”
Gleeson is the first to admit that the findings represent only an initial step in discovering whether Zika can endanger adult human brain cells. For starters, the study was conducted only in mice, and only at a single point in time. More research will be necessary to see whether the results of the mouse model translates to humans, and whether the damage to adult brain cells can cause long-term neurological damage or affect behavior.
But the initial findings suggest that the Zika virus, which has spread to the United States and more than 60 other countries over the past year, may not be as innocuous as it seems for adults, most of whom never realize they have been infected. Researchers found that infected mice had more cell death in their brains and reduced generation of new neurons, which is key to learning and memory. The possible consequences of damaged neural progenitor cells in humans would include cognitive problems and a higher likelihood for conditions such as depression and Alzheimer’s disease.
William Schaffner, an infectious-disease expert at Vanderbilt University Medical Center, agreed Thursday that the findings are preliminary. But he also called it troubling.
“Here’s the deal: The more we’ve learned about the Zika virus, the nastier it is,” said Schaffner, who was not involved in the study. He said scientists have had concerns all along about Zika’s ability to damage the brain, but until now the worries have focused mostly on the developing brain. “This mouse study will increase our anxiety. … It’s an additional potential way that this virus can cause human illness.”
That’s a possibility that demands further examination, he said, given the hundreds of thousands of people already infected by Zika — a number that continues to grow daily.
“Our attention, quite understandably, has been devoted to pregnant women and newborns, and preventing those infections,” Schaffner said. “This mouse study will tell investigators that, in addition to pregnant women, you have to establish some studies in older children and adults as well.”
Gleeson agreed. “We don’t want to have this be a panic. Zika, for the most part, is a benign condition in healthy humans,” he said. “But we also need to look at the potential consequences in a careful way.”