Omega-3 fatty acid supplementation does not affect insulin resistance in PCOS


Women with polycystic ovary syndrome likely receive no benefit from daily omega-3 fatty acid supplementation, according to a meta-analysis of three randomized controlled trials.

“Reducing the levels of serum insulin and increasing insulin sensitivity are considered to be of paramount importance for therapeutic targets in PCOS,”Alirez Sadeghi, of the department of cellular and molecular nutrition at the School of Nutritional Sciences and Dietetics at Tehran University of Medical Sciences, Iran, and colleagues wrote. “Omega-3 fatty acids may lead to insulin sensitivity by producing and secreting anti-inflammatory adipokines, such as adiponectin, and also through reducing inflammation and proinflammatory cytokines. Although it is said that omega-3 fatty acids have positive effects on insulin resistance, various studies have indicated contradictory results.”

Sadeghi and colleagues analyzed data from three studies that measured the association between oral omega-3 supplementation and insulin resistance inwomen with PCOS. Studies were conducted in Australia, Iran and the United States, and included 72 women with PCOS and 73 controls. All studies were double blind and published between 2009 and 2012 with follow-up between 6 and 8 weeks. In all three studies, PCOS groups received 1.2 g to 3.6 g daily omega-3 supplementation containing eicosapentaenoic acid and docosahexaenoic acid (median, 2.7 g); control groups received an oral placebo (olive oil, soybean oil or other placebo). Researchers assessed plasma fatty acid composition in one study; participants maintained their usual diet during intervention in two of the studies; daily energy intake was assessed at baseline and end of intervention in two studies.

In women with PCOS, researchers found that omega-3 fatty acid supplementation did not affect insulin plasma level (mean difference: 6.018; 95% CI, –3.347 to 15.382) or homeostasis model assessment of insulin resistance (HOMA-IR; mean difference: 0.276; 95% CI, –1.428 to 1.981), with high heterogeneity observed for both. The researchers noted that samples sizes in the included studies were low, and further, high-quality randomized controlled trials are needed to validate the findings. – by Regina Schaffer

Why 80% of Us Are Deficient In Magnesium


Magnesium Deficiency Symptoms and Diagnosis

We thirst for magnesium rich water.

Magnesium deficiency is often misdiagnosed because it does not show up in blood tests – only 1% of the body’s magnesium is stored in the blood.

Most doctors and laboratories don’t even include magnesium status in routine blood tests. Thus, most doctors don’t know when their patients are deficient in magnesium, even though studies show that the majority of Americans are deficient in magnesium.

Consider Dr. Norman Shealy’s statements, “Every known illness is associated with a magnesium deficiency” and that, “magnesium is the most critical mineral required for electrical stability of every cell in the body. A magnesium deficiency may be responsible for more diseases than any other nutrient.” The truth he states exposes a gapping hole in modern medicine that explains a good deal about iatrogenic death and disease. Because magnesium deficiency is largely overlooked, millions of Americans suffer needlessly or are having their symptoms treated with expensive drugs when they could be cured with magnesium supplementation.

One has to recognize the signs of magnesium thirst or hunger on their own since allopathic medicine is lost in this regard. It is really something much more subtle then hunger or thirst but it is comparable. In a world though where doctors and patients alike do not even pay attention to thirst and important issues of hydration, it is not hopeful that we will find many recognizing and paying attention to magnesium thirst and hunger, which is a dramatic way of expressing the concept of magnesium deficiency.

Few people are aware of the enormous role magnesium plays in our bodies. Magnesium is by far the most important mineral in the body. After oxygen, water, and basic food, magnesium may be the most important element needed by our bodies; vitally important, yet hardly known. It is more important than calcium, potassium or sodium and regulates all three of them. Millions suffer daily from magnesium deficiency without even knowing it

In fact, there happens to be a relationship between what we perceive as thirst and deficiencies in electrolytes. I remember a person asking, “Why am I dehydrated and thirsty when I drink so much water?” Thirst can mean not only lack of water but it can also mean that one is not getting enough nutrients and electrolytes. Magnesium, Potassium, Bicarbonate, Chloride and Sodium are some principle examples and that is one of the reasons magnesium chloride is so useful.

A man with magnesium deficiency
Magnesium Torment (Deficiency)

You know all those years, when doctors used to tell their patients ‘its all in your heads,’ were years the medical profession was showing its ignorance. It is a torment to be magnesium deficient on one level or another. Even if it’s for the enthusiastic sport person whose athletic performance is down, magnesium deficiency will disturb sleep and background stress levels and a host of other things that reflect on the quality of life. Doctors have not been using the appropriate test for magnesium – their serum blood tests just distort their perceptions. Magnesium has been off their radar screens through the decades that magnesium deficiencies have snowballed.

Symptoms of Magnesium Deficiency

The first symptoms of deficiency can be subtle – as most magnesium is stored in the tissues, leg cramps, foot pain, or muscle ‘twitches’ can be the first sign. Other early signs of deficiency include loss of appetite, nausea, vomiting, fatigue, and weakness. As magnesium deficiency worsens, numbness, tingling, seizures, personality changes, abnormal heart rhythms, and coronary spasms can occur.

A full outline of magnesium deficiency was beautifully presented in a recent article by Dr. Sidney Baker. “Magnesium deficiency can affect virtually every organ system of the body. With regard to skeletal muscle, one may experience twitches, cramps, muscle tension, muscle soreness, including back aches, neck pain, tension headaches and jaw joint (or TMJ) dysfunction. Also, one may experience chest tightness or a peculiar sensation that he can’t take a deep breath. Sometimes a person may sigh a lot.”

“Symptoms involving impaired contraction of smooth muscles include constipation; urinary spasms; menstrual cramps; difficulty swallowing or a lump in the throat-especially provoked by eating sugar; photophobia, especially difficulty adjusting to oncoming bright headlights in the absence of eye disease; and loud noise sensitivity from stapedius muscle tension in the ear.”

“Other symptoms and signs of magnesium deficiency and discuss laboratory testing for this common condition. Continuing with the symptoms of magnesium deficiency, the central nervous system is markedly affected. Symptoms include insomnia, anxiety, hyperactivity and restlessness with constant movement, panic attacks, agoraphobia, and premenstrual irritability. Magnesium deficiency symptoms involving the peripheral nervous system include numbness, tingling, and other abnormal sensations, such as zips, zaps and vibratory sensations.”

“Symptoms or signs of the cardiovascular system include palpitations, heart arrhythmias, and angina due to spasms of the coronary arteries, high blood pressure and mitral valve prolapse. Be aware that not all of the symptoms need to be present to presume magnesium deficiency; but, many of them often occur together. For example, people with mitral valve prolapse frequently have palpitations, anxiety, panic attacks and premenstrual symptoms. People with magnesium deficiency often seem to be “uptight.” Other general symptoms include a salt craving, both carbohydrate craving and carbohydrate intolerance, especially of chocolate, and breast tenderness.”

Magnesium is needed by every cell in the body including those of the brain. It is one of the most important minerals when considering supplementation because of its vital role in hundreds of enzyme systems and functions related to reactions in cell metabolism, as well as being essential for the synthesis of proteins, for the utilization of fats and carbohydrates. Magnesium is needed not only for the production of specific detoxification enzymes but is also important for energy production related to cell detoxification. A magnesium deficiency can affect virtually every system of the body.

Water rich in magnesium can prevent magnesium deficiency
Like water we need magnesium everyday. There is an
eternal need for magnesium as well as water and when
magnesium is present in water life and health are enhanced.

One of the principle reason doctors write millions of prescriptions for tranquilizers each year is the nervousness, irritability, and jitters largely brought on by inadequate diets lacking magnesium. Persons only slightly deficient in magnesium become irritable, highly-strung, and sensitive to noise, hyper-excitable, apprehensive and belligerent. If the deficiency is more severe or prolonged, they may develop twitching, tremors, irregular pulse, insomnia, muscle weakness, jerkiness and leg and foot cramps.

If magnesium is severely deficient, the brain is particularly affected. Clouded thinking, confusion, disorientation, marked depression and even the terrifying hallucinations of delirium tremens are largely brought on by a lack of this nutrient and remedied when magnesium is given. Because large amounts of calcium are lost in the urine when magnesium is under supplied, the lack of this nutrient indirectly becomes responsible for much rampant tooth decay, poor bone development,osteoporosis and slow healing of broken bones and fractures. With vitamin B6 (pyridoxine), magnesium helps to reduce and dissolve calcium phosphate kidney stones.

Magnesium deficiency may be a common factor associated with insulin resistance. Symptoms of MS that are also symptoms of magnesium deficiency include muscle spasms, weakness, twitching, muscle atrophy,  an inability to control the bladder, nystagmus (rapid eye movements), hearing loss, and osteoporosis.  People with MS have higher rates of epilepsy than controls.  Epilepsy has also been linked to magnesium deficiencies.

Another good list of early warning symptoms suggestive of magnesium insufficiency:

  • Physical and mental fatigue
  • Persistent under-eye twitch
  • Tension in the upper back, shoulders and neck
  • Headaches
  • Pre-menstrual fluid retention and/or breast tenderness

Possible manifestations of magnesium deficiency include:

  • Low energy
  • Fatigue
  • Weakness
  • Confusion
  • Nervousness
  • Anxiousness
  • Irritability
  • Seizures (and tantrums)
  • Poor digestion
  • PMS and hormonal imbalances
  • Inability to sleep
  • Muscle tension, spasm and cramps
  • Calcification of organs
  • Weakening of the bones
  • Abnormal heart rhythm

Severe magnesium deficiency can result in low levels of calcium in the blood (hypocalcemia). Magnesium deficiency is also associated with low levels of potassium in the blood (hypokalemia). Magnesium levels drop at night, leading to poor REM (Rapid Eye Movement) sleep cycles and unrefreshed sleep. Headaches, blurred vision, mouth ulcers, fatigue and anxiety are also early signs of depletion.

image

We hear all the time about how heart disease is the number one health crisis in the country, about how high blood pressure is the “silent killer”, and about how ever increasing numbers of our citizens are having their lives and the lives of their families destroyed by diabetes, Alzheimer’s disease, and a host of other chronic diseases.

Signs of severe magnesium deficiency include:

  • Extreme thirst
  • Extreme hunger
  • Frequent urination
  • Sores or bruises that heal slowly
  • Dry, itchy skin
  • Unexplained weight loss
  • Blurry vision that changes from day to day
  • Unusual tiredness or drowsiness
  • Tingling or numbness in the hands or feet
  • Frequent or recurring skin, gum, bladder or vaginal yeast infections

But wait a minute, aren’t those the same symptoms for diabetes? Many people have diabetes for about 5 years before they show strong symptoms. By that time, some people already have eye, kidney, gum or nerve damage caused by the deteriorating condition of their cells due to insulin resistance and magnesium deficiency. Dump some mercury and arsenic on the mixture of etiologies and pronto we have the disease condition we call diabetes.

Magnesium deficiency is synonymous with diabetes and is at the root of many if not all cardiovascular problems.

Magnesium deficiency is a predictor of diabetes and heart disease both; diabetics both need more magnesium and lose more magnesium than most people. In two new studies, in both men and women, those who consumed the most magnesium in their diet were least likely to develop type 2 diabetes, according to a report in the January 2006 issue of the journal Diabetes Care. Until now, very few large studies have directly examined the long-term effects of dietary magnesium on diabetes. Dr. Simin Liu of the Harvard Medical School and School of Public Health in Boston says, “Our studies provided some direct evidence that greater intake of dietary magnesium may have a long-term protective effect on lowering risk,” said Liu, who was involved in both studies.

The thirst of diabetes is part of the body’s response to excessive urination. The excessive urination is the body’s attempt to get rid of the extra glucose in the blood. This excessive urination causes the increased thirst. But we have to look at what is causing this level of disharmony. We have to probe deeper into layers of cause. The body needs to dump glucose because of increasing insulin resistance and that resistance is being fueled directly by magnesium deficiency, which makes toxic insults more damaging to the tissues at the same time.

When diabetics get too high blood sugars, the body creates “ketones” as a by-product of breaking down fats. These ketones cause blood acidity which causes “acidosis” of the blood, leading to Diabetic Ketoacidosis (DKA), This is a very dangerous condition that can lead to coma and death. It is also called “diabetic acidosis”, “ketosis”, “ketoacidosis” or “diabetic coma”. DKA is a common way for new Type 1 diabetics to be diagnosed. If they fail to seek medical advice on symptoms like urination, which is driving thirst they can die of DKA.

Oral magnesium supplements reduce erythrocyte[2] dehydration.[3] In general, optimal balances of electrolytes are necessary to maintain the best possible hydration. Diabetic thirst is initiated specifically by magnesium deficiency with relative calcium excess in the cells. Even water, our most basic nutrient starts having a hard time getting into the cells with more going out through the kidneys.

Autism and Magnesium Deficiency

When dealing with autism spectrum and other neurological disorders in children it is important to know the signs of low magnesium: restless, can’t keep still, body rocking, grinding teeth, hiccups, noise sensitive, poor attention span, poor concentration, irritable, aggressive, ready to explode, easily stressed. When it comes to children today we need to assume a large magnesium deficiency for several reasons.

1) The foods they are eating are stripped of magnesium because foods in general, as we shall see below are declining in mineral content in an alarming way.

2) The foods many children eat are highly processed junk foods that do not provide real nutrition to the body.

3) Because most children on the spectrum are not absorbing the minerals they need even when present in the gut. Magnesium absorption is dependent on intestinal health, which is compromised totally in leaky gut syndromes and other intestinal problems that the majority of autism syndrome disorders.

4) Because the oral supplements doctors rely on are not easily absorbed, because they are not in the right form and because magnesium in general is not administered easily orally.

Modern medicine is supposed to help people not hurt them, but with their almost total ignorance of magnesium doctors end up hurting more than they help for many of the medical interventions drive down magnesium levels when they should be driving them up. Many if not most pharmaceutical drugs drive magnesium levels into very dangerous zones and surgery done without increasing magnesium levels is much more dangerous then surgery done with.

The foundation of medical arrogance is actually medical ignorance and the only reason ignorance and arrogance rule the playing field of medicine is a greed lust for power and money. Human nature seems to be at its worst in modern medicine when it should be at its best. It is sad that people have to suffer needlessly and extraordinarily tragic that allopathic medicine has turned its back on the Hippocratic Oath and all that it means.

Big Pharma’s Dirty Little Secret: Vaccine-Induced Autoimmune Injury


Big Pharma’s Dirty Little Secret: Do Bleeding Calves, Narcolepsy and Infertility Have the Same Mechanism for Vaccine Injury?

Nasal flu vaccine left  energetic and happy 10-year-old Bobby Hunter with disease that makes him afraid to smile 

Scientists reveal how a hyperactivated immune system can unleash disease

Bobby Hunter was 10 years old when his mother noticed her usually energetic boy was struggling to stay awake and he looked exhausted all the time. Then he began collapsing. Eventually Bobby was diagnosed with narcolepsy, a lifelong incurable condition where victims suddenly drop into deep dream sleep, sometimes a dozen times a day or more. It can be accompanied by bizarre and terrifying symptoms: waking hallucinations of demons, insomnia, sleep paralysis and a sudden loss of muscle control or cataplexy often triggered by strong emotions. Bobby now has to be accompanied everywhere he goes in case he falls unconscious; he’ll never bathe or drive or cross a street alone. But his case is particularly cruel. Now, he is a child who is afraid to smile or laugh because it might trigger an attack.

Bobby’s mother Amanda is adamant he first became ill after he received the nasal flu vaccine at his school. But could such a small thing cause such a devastating disorder?

Narcolepsy Nightmare Explained

This month at the 10th Autoimmunity Congress in Leipzig, Germany a leading pharmaceutical researcher presented his international team’s findings suggesting that vaccination could indeed have the “unexpected” effect of inducing crippling narcolepsy, an autoimmune disease.

Sohail Ahmed, lead author of a ground breaking paper published last summer in Science Translational Medicine explained how the now-retracted Pandemrix vaccine was implicated in a narcolepsy epidemic of more than 1,300 children in several European countries and spates of cases linked to other vaccines for the 2009 swine flu pandemic that never materialized.

It turns out,  part of the influenza nucleoprotein in the swine flu vaccine looked (molecularly) just like a receptor for a neurotransmitter in the brain called orexin that regulates the sleep/wake cycle, explained, Ahmed former global head of clinical sciences at Novartis and later GlaxoSmithKline who is currently with Roche Pharmaceuticals.

When the vaccine was injected with an adjuvant to ramp up the immune response, the immune system went into overdrive. Something  — maybe chemical ingredients in the vaccine, maybe inflammation  –  breached the blood brain barrier and the immune system targeting the vaccine virus also locked in on the receptors in the brain sleep centre. Narcoleptic patients’ own immune system then destroyed a hub of 70,000 or so orexin-producing cells in their brains before their hosts started knocking out. The autoimmune reaction can’t be turned off because the immune system is programmed to relentlessly attack anything it perceives as a foreign invader. It’s a case of mistaken identity and in immunology it’s called a “cross-reaction.”

But could other vaccines still in circulation that contain the H1N1 virus trigger narcolepsy too? Could the same mechanism cause kids like Bobby Hunter to get narcolepsy from the nasal flu vaccine?

Both Ahmed and immunologist Maria Teresa Arango at Leipzig confirmed that it could indeed. Bobby probably carries the HLA-DQB1*0602 genetic marker that leaves him at a higher risk of getting narcolepsy. But so does 20% of the US population. For pharmaceutical industry dependents like Ahmed, so long as cases like Bobby’s are not epidemic as they were with Pandemrix, they are collateral damage the pharmaceutical industry is willing continue to keep flu vaccines rolling.

But what if other vaccine proteins are acting in more unexpected ways, contributing to other autoimmune diseases?

Arango said such cross-reactivity could be the underlying mechanism for widely varied and unexpected documented vaccine adverse autoimmune events affecting other parts of the brain or body. She pointed to the work of Dr. Darja Kanduc.

Massive Peptide Sharing, Massive Autoimmunity?

Kanduc is a biochemist at the University of Bari in Italy who presented her findings in Leipzig at a one-day symposium on vaccine safety sponsored by the Children’s Medical Safety Research Institute. Bari has been looking for molecular similarities between microbial and human proteins and found that a massive, unexpected “peptide sharing” exists between human proteins and microbe proteins.

Where overlap (“peptide sharing”) occurs between a foreign protein and human protein, they have a same identical amino acid sequence (for example, SLVDTYR).  An immune response launched against SLVDTYR might hit A (the microbial protein) and also B (the human protein). In immunology terms, this is a cross-reaction between A and B — in the same way Ahmed’s team illustrated vaccine-induced narcolepsy.

Normally such cross-reactions do not occur, explains Kanduc. “In fact, the human immune system has been ‘educated’ to ignore foreign proteins and avoid cross-reactions in order not to harm the similar human ‘self’ proteins.” In immunology, this is called immunotolerance. Our immune system does not press the panic button and launch an attack on every foreign viral protein it encounters.

Tolerance Lost

Our natural immunotolerance has proved a big problem for vaccine manufacturers over the years. Simply injecting a viral or bacterial particle into our bodies does not trigger the immune storm they want. Our bodies aren’t designed to encounter pathogens via intramuscular injection, after all. Our immune system refuses to attack the injected pathogen since that would mean also attacking the look-alike human proteins. It would rather not go to war than risk the home casualties.

Imagine the immune system as a border guard. If a guard at the Canada-US border pulled every vehicle that drove up to his checkpoint aside, emptied the suitcases, called in the sniffer dogs, strip-searched the occupants and called for the SWAT team, things would get ugly pretty fast. Most of the time, border guards are alert but passive. Our immune system is the same way with foreign proteins.

So vaccine manufacturers pepper vaccines with adjuvants — crude extracts of mycobacteria, toxins such as mercury, aluminum salts, or mineral oils to force the reluctant immune system to go into attack mode – from passive border guard to hypervigilant nutter pulling a gun on a granny.  Celebrated Yale immunologist Charles Janeway called this “immunologist’s dirty little secret” underlying vaccination.

 “Adjuvants expand, potentiate, and increase immune responses,” explains Kanduc. “Such hyperactivation has a price: the loss of specificity. The hyper-stimulated immune system does not discriminate any more between foreign proteins and self-proteins…Adjuvants render the immune system blind. Human proteins that share peptide sequences will be attacked.”

Kanduc likens immunotolerance to a protective wall. “The dam is demolished by the adjuvants and the cross-reactivity flood can crush and alter human proteins.” This might also cause numerous cross-reactions, manifested as a wide variety of autoimmune attacks.

Can vaccines induce genetic disease?

Kanduc looked for peptide sharing between a single influenza A H5N1 protein and human proteins. She found that the viral protein shares 70 peptides with the human host — proteins involved in basic cell functions including proliferation, neurodevelopment, and differentiation.

Among the human proteins that could be on the firing range: reelin, a protein involved in neuron layering, neurexins, proteins that connect neurons,  syndrome 10 protein for Bardet-Biedl syndrome, a transcription factor for Williams Syndrome (a rare genetic neurodevelopmental disorder), a protein associated with amyotrophic lateral sclerosis, and so on.

When these human proteins are altered, as for example by genetic mutations, neurological disorders such as epilepsy, obesity, dystonia, amyotrophic lateral sclerosis, Sudden Infant Death Syndrome and demyelinating diseases like multiple sclerosis occur, says Kanduc.

 “The same spectrum of diseases might occur if these human proteins are attacked and altered by cross-reactions following an expanded and indiscriminate immune response induced by an adjuvant vaccine,” she adds.

With such “massive overlap” of proteins, the potential for vaccines to induce all sorts of autoimmune diseases is possible; it explains why such diverse autoimmune phenomena have been documented in the medical literature with respect to vaccination, from neurological disorders to skin afflictions to impaired fertility.

“The type of autoimmune phenomenon and disease that is eventually established will depend on the molecules and organs attacked,” explains Kanduc. “For example, attacks against myelin may evoke demyelinating diseases [such as multiple sclerosis] whereas immune reactions against proteins involved in behaviour  and /or cognition may cause autism and behaviour disorders.”

Autoimmune Infertility?

Such autoimmunity may be the mechanism underlying cases of premature menopause and infertility in adolescent girls following injection with the vaccine against HPV, described in Leipzig by an Australian GP. Deirdre Little, a general practitioner in South Bellingen, first published a case study of her 16-year-old patient who developed premature ovarian insufficiency (POI) following HPV vaccination. Since then Little has encountered six more post-HPV cases of sterility in adolescents in her practice – though primary ovarian insufficiency is almost unheard of  — normally affecting one in 100,000 girls under age 20.

Little and Harvey Ward, the Australian obstetrician gynaecologist who co-authored her studies, highlighted their concerns that the HPV vaccine’s impact on fertility has not been researched.

What’s more, she said:  “The ‘saline’ placebo control for this vaccine target group was not saline.” Little discovered that even product information was misleading on this point and failed to mention that the “placebo” for the HPV contained the toxic metal aluminium and polysorbate 80 – an ingredient which has exhibited delayed ovarian toxicity to rat ovaries at all injected doses tested over a tenfold range.

Polysorbate 80 has been compared to diethylstilbestrol (DES), a cancer drug given to women until 1971 when it was shown to induce cancer. Later researchers discovered children who were exposed to DES in utero also had high risk of cervical cancer and infertility.

“The definition of a safe drug is when the children of the people who have taken it can reproduce healthy children,”

said Ward. It will be a long time yet before the HPV vaccine can be declared safe.

Contraceptive researchers have been trying to make a birth control vaccine for decades – primarily by vaccinating against female hormones such as follicle stimulating hormone andhuman chorionic gonadotropin. They’ve been hampered by their inability to rein in the triggered immune system; besides FSH and HcG, it attacks look-alike sequences on hormones such as thyroid and leutenizing hormone.

 “Our goal with our vaccine was to develop autoimmunity,” Bonnie Dunbar, a 20-year veteran vaccine researcher, told the 4th International Public Conference on Vaccination in 2010, according to a report from the Population Research Institute. Dunbar tried to train rabbits’ immune systems to attack proteins on their ova using pig proteins in her vaccine to “trick the rabbit into inducing antibodies against its own self proteins.”

Instead, she inadvertently launched a full-scale immune assault that completely destroyed their ovaries. “Unfortunately, we weren’t just looking at preventing fertilization now,” said Dunbar, “we generated a complete autoimmune disease, which is also known as premature ovarian failure.”

Is it possible that components of HPV vaccines share sequences with components of the reproductive system?

Do Vaccines Create New Diseases?

In 2007 cattle farmers in Europe began reporting a bizarre new disease among calves. Sometimes the new-born animals were just found dead, but others, usually less than a month old, would develop nosebleeds, black tarry stools and high fevers. Sometimes ear tagging, or the slightest scratch or knock would lead to uncontrollable bleeding. Something appeared to be destroying platelets in the blood of these animals, and post mortems revealed massive internal bleeding and almost completely decimated bone marrow.

By 2009 the disease was in the UK, and while it usually only affected one or two animals on a given farm, sometimes it affected as many as 10 percent of new-borns and it was almost always lethal. Eventually it would kill at least 4,500 calves. Vets suspected many more cases were going unreported and there was no sign of the mystery abating. Veterinary agencies were growing alarmed. The first epidemiology reports in 2009 confirmed rumours: the new disease called Bleeding Calf Syndrome, or bovine neonatal pancytopenia in academic circles, had something to do with Pfizer’s new PregSure vaccine against bovine viral diarrhea (BVD). In 2010 the vaccine was pulled from the market.

BVD spreads easily among intensively farmed animals (not so much grass-fed), and it causes diarrhea, lowers milk production and can cause stillbirths. A calf infected in utero that survives can be persistently infected throughout its lifetime and keep the disease circulating. The PregSure vaccine was given to pregnant cows to avoid BVD transmission to developing calves.

But a host of studies conducted by European agriculture ministries and veterinary researchers revealed the underlying mechanism: the vaccine caused the dams to produce aggressive anti-viral antibodies, present in their colostrum, which also attacked the newborn calves’ blood cells when they drank them.

Today, six years after PregSure was discontinued, previously vaccinated dams are still producing bleeding calves.

Vaccines In Pregnancy

Bleeding Calf Syndrome raises a host of questions: What do these findings suggest for humans? What happens when pregnant women are vaccinated against foreign proteins? The CDC advises women to get vaccinated before, during and after pregnancy. Do these women pass on potentially cross-reactive antibodies to their babies as well?

It seems the industry is aware of the enormous implications of the phenomenon. A studypublished two months ago in the journal Vaccine states that,

“Although maternal vaccination is generally considered to be safe, the occurrence of Bovine Neonatal Pancytopenia (BNP) in cattle shows that maternal vaccination may pose a risk to the offspring.”

“The occurrence of BNP years after last PregSure© BVD vaccination indicates that alloantibody levels may remain high in dams,” it adds. Alloantibodies are immune system components that recognize and attack proteins with genetic differences within species – as between a host and a tissue transplant graft, for example. “Since pregnancy induces alloantibodies we hypothesized that pregnancy boosts the vaccine-induced alloantibody response,” explain the researchers from the Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine at Utrecht University in The Netherlands.

Pregnancy seems to reactivate the immune system and relaunch antibody production – in calf after calf. It also suggests that pregnancy is a particularly vulnerable window for launching autoimmune disease.

Subclinical Disease

You may be reassured to think only several thousand calves died from the PregSure vaccine, but recent veterinary studies have demonstrated that the bleeding calves are not all of the affected newborns. A 2014 study found that while only three percent of offspring expressed clinical bleeding calf syndrome, 15 percent of the clinically normal calves had “profoundly altered hematology.” Though they were not ill before they were sold, the researchers could not say if they would become so later or in different conditions.

What happens to the subclinical cows? Do they carry these alloantibodies for life and do they become clinically diseased with a stress trigger years later as per Autoimmune/inflammatory Syndrome Induced by Adjuvants?  Are they already experiencing subtle symptoms of disease? I contacted Zoetis Inc. the animal health company that Pfizer spun off in 2013, to ask these questions. They said they would get back to me. I’m still waiting.

Again, the questions about subclinical disease in animals are important for humans. Is it possible that there are subclinical manifestations of other vaccine adverse events?   Scientists havewondered if generalized anxiety and panic disorders might not be subclinical manifestations of narcolepsy, for example, because they also share symptoms of narcolepsy, such as cataplexy. Is it possible that H1N1 antibodies act subtly at lower levels but still have an effect on the brain? Is it possible that other vaccine proteins induce other autoimmune diseases in people with different susceptibilities?

These are questions that haven’t yet registered with public health vaccine advocates who sit in closed-door policy meetings and hold shares in the drugs they mandate. Bleeding calves won’t be on their radar for years, if ever. They still refuse to acknowledge that Pandemrix was linked to narcolepsy – though the industry does. And cases like Bobby Hunter?  Forget it.

Public health regulators’ main interest is preserving the notion that vaccines help more than they harm. Anything else is blasphemous.

For the rest of us, though, a recent review in immunology literature should give pause. It states: “To date, more than 80 systemic and organ-specific autoimmune diseases have been defined, and their cumulative burden is substantial, both medically and financially. Furthermore, the burden of autoimmune and autoinflammatory diseases is rising, making these diseases a ubiquitous global phenomenon that is predicted to further increase in the coming decades.”

An autoimmune storm is rising. The role of vaccines in it is emerging and will one day be crystal clear. The question is, how far off is that day, and who is going to pay while we wait for it?

Best Diaper Changing Technique for Newborns to Reduce Colic


I’ll never forget the moment, sitting there in a post-graduate seminar in Chicago, when I realized that as a chiropractor I had been really, really messing something up.  I wasn’t a newbie by any means- I’d been in family practices for 7 years by this point, served my profession at the state and national level, and won a major award for my alternative health news podcast.  But here I was at the Doubletree being shown the most basic concept about changing an infant’s diaper, and I was dumbfounded.

Most of us do the double-leg lift.  Okay, let me write that another way:  Almost all of us do the sniff check, undo the diaper, lift the baby up by the legs to get the dirty out, wipe the creases and insert the clean one in.  A couple swipes of the tape, Velcro or snaps and it’s all done.  It’s the way we’ve seen it done in the movies, on TV, and in our own living rooms for generations.  It’s even rational- once new babies discover their feet, it’s almost impossible to keep them out of their mouths!  But I’ll tell you this- the way most of us have intuitively changed a diaper is not sound spinal biomechanics, and it very well may be the cause of your baby’s colic.

That’s where the face to palm moment came for me.  As a chiropractor in family practice, I’d seen plenty of colicky babies.  We’ve done plenty of research on it as a profession and have witnessed pretty impressive results- one study showed adjustments were more effective than medication for colic, and another showed a 93% success rate in helping children with the symptoms of gas, bloating and pain.  We understand that the intestines get a large portion of their nerve information from the area of the spine near the bottom of the rib cage and the upper portion of the low back.

It’s one of the areas we check when a parent brings their child in with colic symptoms because interference to that flow keeps the intestines from functioning properly.   If the area is being interfered with, or subluxated, than adjustments help restore normal function and allow the body to heal.  The reason chiropractic works so well for babies is that it deals directly with the nerve system, and that’s the system running the whole show.  I’d been doing this in practice for years, but I was missing something pretty important.

When we’re born we have one spinal curve.  It’s the fetal position, the c-shape that our middle backs keep, which is necessary to stay tucked nice and snuggly inside our moms.  That primary curve is the only curve we have as an infant until we build the other two in our spine.  The first re-shaping of the cervical spine happens in our necks when we learn to lift our bobbly heads and hold them up.  The second, called the lumbar curve, happens in the low back, and it forms when we learn how to crawl.  We need these secondary curves to support our body weight for standing, bending, and lifting.

But until we build them, the mechanics of the spine function very differently.  If you think of a baby’s spine like a bridge, one that doesn’t have a cervical or lumbar curve, then the peak of the bridge is between the 9th and 11th vertebra in the thoracic spine.  To give you an idea of where that is on you, the ribs that make up your ribcage exit at the 8th thoracic vertebra, and the “floater” ribs exit from the 9th to the 12th.  Compare that to where an adult’s peak is -right between the shoulder blades- and you’re going to come to the same realization I did

If you were hunched over a lot, like if you were working on a laptop or driving for too long, most people start feeling tightness in their middle backs as their vertebra start creeping backwards out of position.  The more you do it, the more sore it gets.  In a way this is exactly what is going on with our babies when we raise their legs over and over again to change their diapers- a lot of parents without realizing it are causing the subluxations and nerve interference that results in the colic I see in the office.  Yet until that class, I had no idea why I kept seeing the same colicky kids over and over again!

The double leg lift is pretty intuitive, so I don’t blame us for thinking it was the right way to change a baby.  Infants are folded inside mom, and once they discover their feet it’s virtually impossible to keep them out of their mouths.  But the difference in the bending here is at the hip joint.  The femur heads in infants are barely developed because they don’t need the bony structure for standing or the muscle strength and tension for walking.

That lets them fling their feet over their heads and giggle without even thinking about it.  But when we use those legs for handles for a child who doesn’t have that secondary lumbar curve, we’re folding the spine at its peak, pushing the vertebra out of alignment where the nerve flow for the intestines comes out, and we’re doing this how many times?  Three?  Five?   Seven times a day?  No wonder chiropractic has such a high success rate with colicky babies – we just put back what parents keep putting out!

We need to break this cycle, for everyone’s sanity.  This is why I advocate the roll technique for diaper changing babies who haven’t started crawling yet.  It takes a little practice, but after a few days you’ll get used to it.  Holding the baby by her chest and rolling side to side keeps her spine in alignment and will help hold her adjustments so much better.  To see this in action, visithttp://youtu.be/l9IDpEVkemM

To find a chiropractor near you with a special focus on the needs of infants and children, please visit the International Chiropractic Pediatrics Association’s website, http://icpa4kids.org/Find-a-Chiropractor/.

 

How To Clean Your Arteries With One Simple Fruit


How To Clean Your Arteries With One Simple Fruit

The future of cardiovascular disease prevention and treatment will not be found in your medicine cabinet, rather in your kitchen cupboard or in your back yard growing on a tree.

Pomegranate Found To Prevent Coronary Artery Disease Progression

A new study published in the journal Atherosclerosis confirms that pomegranate extract may prevent and/or reverse the primary pathology associated with cardiac mortality: the progressive thickening of the coronary arteries caused by the accumulation of fatty materials known as atherosclerosis.[i]

Mice with a genetic susceptibility towards spontaneous coronary artery blockages were given pomegranate extract via their drinking water for two weeks, beginning at three weeks of age. Despite the fact that pomegranate treatment actually increased cholesterol levels associated with very low density lipoprotein-sized particles, the treatment both reduced the size of the atherosclerotic plaques in the aortic sinus (the dilated opening above the aortic valve) and reduced the proportion of coronary arteries with occlusive atherosclerotic plaques.

Remarkably, the researchers also found that pomegranate extract treatment resulted in the following beneficial effects:

  • Reduced levels of oxidative stress
  • Reduced monocytie chemotactic protein-1, a chemical messenger (chemokine) associated with inflammatory processes within the arteries.
  • Reduced lipid accumulation in the heart muscle
  • Reduced macrophage infiltration in the heart muscle
  • Reduced levels of monocyte chemotactic protein-1 and fibrosis in the myocardium
  • Reduced cardiac enlargement
  • Reduced ECG abnormalities

How can something as benign and commonplace as a fruit extract reverse so many aspects of coronary artery disease, simultaneously, as evidenced by the study above?  The answer may lie in the fact that our ancestors co-evolved with certain foods (fruits in particular) for so long that a lack of adequate quantities of these foods may directly result in deteriorating organ function.  Indeed, two-time Nobel Prize winner Linus Pauling argued that vitamin C deficiency is a fundamental cause of cardiovascular disease, owing to the fact that our hominid primate ancestors once had year-round access to fruits, and as a result lost the ability to synthesize it.  [see Linus Pauling vitamin C lecture on GreenMedTV]

Pomegranate Found To Prevent Coronary Artery Disease Progression

Discussion

This study adds to the already extant body of clinical research indicating that pomegranate can help unclog your arteries.  For instance, back in 2004, the journal Clinical Nutrition published the results of a three year clinical trial in an Israeli population, finding that the daily consumption of pomegranate juice reversed carotid artery stenosis by up to 29% within 1 year.  Remarkably, the blockages in the control group increased 9%, indicating that pomegranate’s artery unblocking effects were even greater than at first apparent. [ii]

Pomegranate’s value in cardiovascular disease is quite broad, as evidenced by the following experimentally confirmed properties:

  • Anti-inflammatory: Like many chronic degenerative diseases, inflammation plays a significant role in cardiovascular disease pathogenesis. There are five studies on GreenMedInfo.com indicating pomegranate’s anti-inflammatory properties.[iii]
  • Blood-Pressure Lowering: Pomegranate juice has natural angiotensin converting enzyme inhibiting properties, [iv] and is a nitric oxide enhancer, two well-known pathways for reducing blood pressure. [v] Finally, pomegranate extract rich in punicalagin has been found reduce the adverse effects of perturbed stress on arterial segments exposed to disturbed flow.[vi]
  • Anti-Infective: Plaque buildup in the arteries often involves secondary viral and bacterial infection, including hepatitis C and Chlamydia pneumoniae.[vii] Pomegranate has a broad range of anti-bacterial and anti-viral properties.
  • Antioxidant: One of the ways in which blood lipids become heart disease-promoting (atherogenic) is through oxidation. LDL, for instance, may be technically ‘elevated’ but harmless as long as it does not readily oxidize. Pomegranate has been found to reduce the oxidative stress in the blood, as measured by serum paraoxonase levels.  One study in mice found this decrease in oxidative stress was associated with 44% reduction in the size of atherosclerotic lesions. [viii]

600 Reasons Turmeric May Be The World’s Most Important Herb


600 Reasons Why Turmeric Is The World's Most Important Herb

 

There is a medicinal spice so timelessly interwoven with the origins of human culture and metabolism, so thoroughly supported by modern scientific inquiry, as to be unparalleled in its proven value to human health and well-being.

Indeed, turmeric turns the entire drug-based medical model on its head.  Instead of causing far more side effects than therapeutic ones, as is the case for most patented pharmaceutical medications, turmeric possesses hundreds of potential side benefits, having been empirically demonstrated to positively modulate over 160 different physiological pathways in the mammalian body.

While no food or herb is right for everyone, and everything has the potential for unintended, adverse side effects, turmeric is truly unique in its exceptionally high margin of safety vis-à-vis the drugs it has been compared with, e.g. hydrocortisone, ibuprofen, chemotherapy agents. Furthermore, nothing within the modern-day pharmaceutical armamentarium comes even remotely close to turmeric’s 6,000 year track record of safe use in Ayurvedic medicine.[1]

Despite its vast potential for alleviating human suffering, turmeric will likely never receive the FDA stamp of approval, due to its lack of exclusivity, patentability and therefore profitability. Truth be told, the FDA’s “gold standard” for proving the value of a prospective medicinal substance betrays the age old aphorism: “he who owns the gold makes the rules,” and unless an investor is willing to risk losing the 800+ million dollars that must be spent upfront, the FDA-required multi-phased double-blind, randomized clinical trials will not occur. For additional details on this rather seedy arrangement read our article on the topic: Why The Law Forbids The Medicinal Use of Natural Substances.

Here at GreenMedInfo.com, we have reviewed over 5,000 study abstracts from the National Library of Medicine’s bibliographic database known as MEDLINE and have discovered over 600 potential health benefits of turmeric, and/or its primary polyphenol known as curcumin. These can be viewed on our turmeric research page which is dedicated to disseminating the research on the topic to a larger audience.

Some of the most amazing demonstrated properties include:

Again, what is so amazing is not that turmeric may have value in dozens of health conditions simultaneously, or that it may improve conditions that are completely resistant to conventional treatment, but that there are over six hundred additional health conditions it may also be valuable in preventing and/or treating. Consider also the fact that turmeric grows freely on the Earth, and you will understand why its very existence threatens billions of dollars in pharmaceutical industry revenue.

Life Is Beautiful, Because You Are Beautiful !!!


  Life Is Beautiful.. I say Life is beautiful.. and i know a lot of many must be whispering.. what the fuck!! Life is a hell… Life is a shit.. people are cheaters, liers…

Amazing Food Science Discovery: Edible Plants ‘Talk’ To Animal Cells, Promote Healing


Amazing Food Science Discovery: Edible Plants 'Talk' To Animal Cells, Promote Healing

A groundbreaking new study published in Molecular Nutrition & Food Research titled, “Interspecies communication between plant and mouse gut host cells through edible plant derived exosome-like nanoparticles,” reveals a new way that food components ‘talk’ to animal cells by regulating gene expression and conferring significant therapeutic effects. With the recent discovery that non-coding microRNA’s in food are capable of directly altering gene expression within human physiology,[1] this new study further concretizes the notion that the age old aphorism ‘you are what you eat’ is now consistent with cutting edge molecular biology.

Exosomes: The ‘Missing Link’ In How Plants and Animal Cells Communicate and Collaborate

This is the first study of its kind to look at the role of exosomes, small vesicles secreted by plant and animal cells that participate in intercellular communication, in interspecies (plant-animal) communication.

The study explained the biological properties of exosomes as follows:

“Exosomes are produced by a variety of mammalian cells including immune, epithelial, and tumor cells [11–15]. Exosomes play a role in intercellular communication and can transport mRNA, miRNA, bioactive lipids, and proteins between cells [16–19]. Upon contact, exosomes transfer molecules that can render new properties and/or reprogram their recipient cells.”

While most of the research on exosomes has focused on their role in pathological states such as tumor promotion, they were recently found to play a key role in stimulating regeneration within damaged cardiac tissue,[2] and are known to be found in human breast milk, further underscoring how irreplaceable it is vis-à-vis synthesized infant formula.[3]

The New Study

The investigators isolated plant derived exosome-like nanoparticles (EPDENs) from ginger, carrot, grape and grapefruit, and observed their behavior in mammalian cells (mice).

They chose these commonly consumed edible fruits and vegetables because,

“It is well established that a plant-derived diet has great influence on regulation of mammalian host cell homeostasis, in particular, cells in the digestive system [1–3]. Deregulation of plant-derived diet regulated host cell homeostasis leads to increased susceptibility to infections, chronic inflammatory bowel diseases, and cancer [4–10].

They noted, “the cellular and molecular machinery regulating such interspecies mutualism between a plant-derived diet and the mammalian gut is not fully defined.” Their new study aimed to gain new insight into defining the mechanisms through which cross-kingdom crosstalk occurs.

Plant Exosomes Affect Mammalian Cells Intimately

After isolating and characterizing exosome-like nanoparticles from all four edible plants, the researchers discovered they possessed remarkable similarity in size and structure to mammalian-derived exosomes. Furthermore, the study showed “that these exosome-like nanoparticles are taken up by intestinal macrophages and stem cells, and have biological effects on the recipient cells.”

The biological effects were described as follows:

  • Ginger exosome-like nanoparticles strongly induced heme oxygenase-1 (HO-1) and IL-10 expressed in macrophages, an indication of anti-inflammatory and antoxidant properties.
  • Fruit-derived exosome-like nanoparticles including grape and grapefruit induced Wnt/TCF4 activation, which is a key component of the anti-inflammatory response
  • All tested foods activated nuclear translocation of Nrf2, a key regulator of the HO1 gene, which has an important role in anti-inflammation and antioxidation; ginger was found to be most potent, followed by grapefruit, carrot and grape

Notably, EPDENs were found to be resistant to gastric and intestinal enzymatic digestion, further indicating they are capable of exerting significant biological effects by escaping digestive degradation, which has also been found with lectins and microRNA’s within edible foods.

The researchers discussed their results:

“Our findings show that exosome-like nanoparticles are present in edible fruits and vegetables and reveal a previously unrecognized strategy by which plants communicate with mammalian cells via exosome-like nanoparticles in the gut, and in particular intestinal macrophages and stem cells. We found that edible plants contain large amounts of nanoparticles. Like mammalian exosomes, further characterization of the plant nanoparticles led to identifying them as exosome- like nanoparticles based on the nanoparticles being com- posed of proteins, lipids, and miRNAs. EPDENs from different types of plants have different biological effects on the recipient mammalian cells. This finding opens up a new avenue to further study the molecular mechanisms underlying how the plant kingdom crosstalks with mammalian cells such as intestinal macrophages and stem cells via EPDENs. This information may provide the molecular basis of using multiple plant-derived agents for better therapeutic effect than any single plant-derived agent.”

They also offered that their results may explain why those who consume a greater variety of edible plants are healthier:

“It has been known for decades that people eating a variety of edible plants daily are the recipients of many beneficial health effects when compared to subjects that ingest fewer types of edible plants. Ingesting EPDENs from a variety of fruits and vegetables daily would be expected to provide greater beneficial effects for maintaining gut homeostasis than ingesting EPDENs from single edible plant.”

Discussion: Deeper Implications of the Study

As part of the fascinating new fields of epigenetics and nutrigenomics, this new study’s findings promise to expand the relevance of food in the practice of medicine and the prevention of disease. We have crossed a critical threshold in the past few decades where food can no longer considered simply as a source of caloric content, minerals and vitamins, and building blocks for the body-machine. [Learn more by taking the author’s E-Course] Rather, food carries very specific forms of biologically meaningful information (literally ‘to put form into’), without which our genetic and epigenetic infrastructure cannot function according to its intelligent design.

The discovery of plant-dervied exosome-mediated modulation of fundamental mammalian cellular pathways, lends powerful support to the concept that ancestral nutritional practices handed down for countless generations are critical in maintaining our health. With the advent of the post-industrial diet, based largely on ‘food-like’ synthesized nutrition, and the novel introduction of grain-based nutrition in only the past 500 generations, our present diet suffers from a series of profoundly biological incompatible foods.

Millions of years of co-evolutionary processes have generated a wide range of interspecies, cross-kingdom co-dependencies. For instance, mammals and angiosperms (which comprise about 250,000 species and include most of the flowering plants that provide the modern world its diet) co-evolved for at least 200 million years together, and are today two of the most dominant forms of life on the planet. The very molecular and informational fabric of our bodies evolved to intimately depend on the presence of various key food components in the human diet, and the absence of others which may be detrimental to our health. Food components like exosomes may be as important to our health as vitamins and other classically defined ‘nutrients,’ and may even be more important in modulating a wide range of complex genetic- and epigenetic-mediated cellular processes within the body. This may also explain the mystery of how certain fruits, such as pomegranate, have been found to replace the function of the mammalian ovary in an ovariectomy induced models of premature aging.  While pomegranate is one of nature’s most concentrated source of bioidentical estrone, exosomes may be the ‘missing link’ as to how a plant food can support complex hormonal processes within the animal body, along with exerting such a wide range of additional therapeutic health effects. This is all the more evidence with plants like turmeric, which have over 600 health benefits and has been found to modulate the expression of thousands of genes simultaneously.[4]

We believe that taken together, the recent discoveries that 1) microRNA’s within foods like rice can enter into our blood and tissue and regulate gene expression 2) that double-stranded RNAs within a wide range of commonly consumed foods have molecular homology with thousands of human RNAs (and are therefore capable of silencing them) 3) that lectins also can directly activate nuclear machinery within certain cells, the addition of exosome-mediated gene modulation, lends further support to the concept that the quality and types of food we consume carry as much relevance in terms of ‘biological destiny’ as the DNA within our genome.

With exciting research now available, the famous quote attributed to Thomas Edison rings truer today than ever:

“The doctor of the future will give no medication, but will interest his patients in the care of the human frame, diet and in the cause and prevention of disease.”

3 Scientific Game Changers That Will Transform Medicine


Gamechanging Science

Think diseases run in the family? Think again.

Have you ever worried about “getting” breast cancer because your mom and aunt both had it? What about Bipolar Disorder (yes, psychiatry capitalizes it’s diagnoses for extra emphasis!) or Lupus? It has probably felt like you have a ticking time bomb inside you and you just want to know when it’s going to go off. When that diagnosis is going to be delivered. Women likeAngelina Jolie have engaged willful mutilation in the name of the persistent belief that genes are destiny.

This is simply not true.

“It runs in my family” no longer means what we once believed it to.

You may not know this yet, but the whole game has changed and we are several decades into the most powerful shift in scientific thinking in the past 300 years. Science, when handled with care, is a process, not a destination.

Science fundamentally reflects our native curiosity, our creative impulse, and our sense of wonder. Along the line, however, it began to take on a different flavor. With men like Newton, Darwin, and Descarte at the microphone, a culture of reductionism, force-based perceptions around the nature of reality, and separation of spirit and matter all predicated the culture of ruthless medicine we are steeped in today. We war against nature, our bodies, and each other. There’s good and bad. There’s the illusion of the objective. We pray at the altar of facts and data.

I used to believe that science meant answers and solutions. And now I don’t. Here’s why.

Anyone who has plumbed the depths of science, either through study, primary research, or experimentation, will reach the limitations of belief in science as the be all end all. Beyond this glass ceiling is the sense of wonder that is stripped from the soulless realm of modern biology. The amazing thing is that, the past several decades have furnished a new kind of science. It’s a science of inquiry rather than utility. The conclusions of today’s abstracts seem to read, “isn’t this amazing?” rather than “here is confirmation that this drug is necessary to manage our wayward biology”. In essence, it reflects a new story about our role in the holobiont, or the more purposeful station we occupy in the web of nature.

In this new story, we are not the result of several billion years of random mutations and survival of the fittest. Instead, we are adapting, as Lamarck once suggested (and even Darwin acquiesced), purposefully. This purposeful adaptation means that we are interacting with our environment in a co-creative dance with balances and micro/macro feedback loops to keep a certain meta-order intact.

How a focus on genes made lifestyle irrelevant

When I was in training, I had one hour of nutrition education that essentially positioned food as caloric currency. Why would it matter if we were born with the diseases we would ultimately struggle with? In gene-based science, toxicant exposure, rest, nutrition, and relationships are clearly window dressing considerations. (Jonathan Latham’s work on identifying the historical influence of the Tobacco industry on the push towards the hume genome project and gene-centricism in medical science is amazing.https://www.independentsciencenews.org/science-media/science-and-social-control-political-paralysis-and-the-genetics-agenda/)

With the completion of the human genome, however, we learned that we have fewer protein-coding genes than an earthworm. This means that the genes we thought made us who we are, don’t.

What?!

We had to go back to the drawing board. Where on earth does our seemingly infinite uniqueness come from? How are diseases manifesting if not genetically?

And a new science was born. It was named epigenetics.

Epigenetics encompasses all that is beyond the genes (it actually means “above”) and includes modulators, modifiers, and any influence on the expression of genes and even the possibility that nonhuman genes may play an expressive role in human physiology. It also refers to the the almost 99% of our genome that was once pejoratively called “junk DNA” and now is more mystically referred to as Dark Matter, as Dr. Jeff Bland describes here.

One of the most powerful examples of the relevance of epigenetics is the lore of the ‘breast cancer gene’. Jolie, and many other women have succumbed to the hex or the belief that they are cursed by their genes, doomed to develop diseased breasts, ovaries, and uteruses if they just go on living with them in their bodies.

The literature, itself claims that gene mutations such as the “breast cancer gene” or BRCAseems to be doing different things over time. Doesn’t that mean, by definition, that we are talking about epigenetics? Because the risk of a gene itself should not change over time. An oft-cited study concludes:

Risks appear to be increasing with time: Breast cancer risk by age 50 among mutation carriers born before 1940 was 24%, but among those born after 1940 it was 67%.

In a timely meta-analysis entitled: Worse Breast Cancer Prognosis of BRCA1/BRCA2 Mutation Carriers: What’s the Evidence? A Systematic Review with Meta-Analysis, the authors conclude:

Our review shows that, in contrast to currently held beliefs of many oncologists and despite 66 published studies, it is not yet possible to draw evidence-based conclusions about the association between BRCA1 and/or BRCA2 mutation carriership and breast cancer prognosis. We only found sufficient evidence for a 10% worse unadjusted recurrence-free survival for BRCA1 mutation carriers. For all the other outcomes the evidence was judged to be indecisive.

This reflects a more modern understanding that only about 1% of diseases are truly genetic in nature (i.e. due to a congenitally inherited and irreversible gene defect), and that we may very well have misunderstood our interpretation of these gene’s functions. The rest is lifestyle. In other words, we create our experience and determine our destiny.

As we embrace our agency in our own bodily experience, we must embrace complexity and take off the blinders of our one gene – one ill – one pill model of thinking. As you open your mind to this shift underfoot, a shift into a more ecological type of medicine, a more collaborative, communal, and connected type of medicine, revel in what the more beautiful science is showing us about our need to let go of what we once believed. It served us, but it’s time has passed.

Here are the 3 most powerful game changers in recent literature:

Gamechanger # 1: The Microbiome

An extension of the one cause – one problem dialectical thinking, is the rush to characterize microbes as pathogens, as bad guys. We have done so for as long as we have been seeking to control and dominate nature. Pestilence and contagion have fit neatly into the lighthouse beam of fear that we sweep across our psychic terrain. But even Pasteur, arguably the father of germ theory, on his deathbed, was reported to say: ” I was wrong. The microbe (germ) is nothing. The terrain (milieu) is everything.”

What is the terrain though? The implication is that we are, in fact, an ecosystem, positioned within an ecosystem. There is no linearity, so that when we pull one thread of the spider web, the entire thing moves.

With the dawning of our awareness that microbes including fungi, bacteria, viruses, and others, live in and around us, we ceased to be human in the ways we had come to believe. We are not, in fact, humans trying to uphold and protect our humanity in a sea of invaders. We are a meta-organism, a holobiont, interfacing with a greater whole, like a fractal repetition of a pattern.

With the emergence of science seeking to study the microbiome, primarily in the gut, we have learned that these bacteria have the capacity to perform some of our most vital human functions, and some that seem to be eerily custodial. Take for example, the fact that there are bacteria in our guts that have evolved to detoxify the chemicals in an average dry cleaner. How could they possibly have foreseen the need for this function? Then there’s the digestion, barrier protection, immune signaling, hormone balancing, and brain controlling functions of the microbiome.

Through this lens, our tonsils and appendix are no longer vestigial, and the special role of a woman’s physiology is recentered as the conduit through which this microbiome passes from mother to fetus, and even through the inheritance of our primary cellular energy production sites – the mitochondria – themselves, ancient bacteria that were assimilated into the human organism over a billion years ago.

Because we know this now, we cannot war against nature any longer. Vaccines and antibiotics, hand sanitizers and bleach are necessarily brought under scrutiny. We will never win this battle because it’s not a battle meant to be won. Nature will continue to remind us of this with the emergence of superbugs, pharmaceutical damage, and disturbed immunity.

The term dysbiosis, used by holistic and integrative practitioners to refer to gut imbalance, of course, actually means “wrong living”. No doubt, our struggles today, stem from a lack of connection to the natural world. It is, in this way, poetic justice that we would only be able to heal our guts, right our relationship to the microbial world through food – nature’s gift, bounty, and language.

Gamechanger #2: Exosomes

The nail in the coffin of protein-coding-gene-determined-health is a group of tiny bubble-like blobs that influence gene expression. Amazingly similar to viruses in nature, structure, and possibly even function, exosomes are created and received by our bodily cells in order to direct, determine, and react to states of being.

40-100nm in diameter, exosomes typically carry something called micro RNA or miRNA which are key regulators of gene expression, naturally impacted by environmental factors, from toxicants, nutrition, and lifestyle patterns.

In fact, seminal research has demonstrated that stable miRNAs are transferred from plants including rice and ginger, into mammalian physiology where they then serve to regulate gene expression. Once again, food is reframes as so much more than calories and nutrients…it is information.

Researchers are suggesting that infant assessments of miRNA patterns may help to identify fetal brain injury from toxic exposures including mercury, aluminum, and medications, at birth, so that healing protocols can be prioritized and initiated. Powerfully, however, in order to understand the “signatures” of different disease states, we would have to study them in their natural unfoldment, without pharmaceutical interventions, before we could ascertain what is evidence of illness and what is evidence of medication effect. The authors state clearly:

“In addition, one must control for the influence of psychotropic drugs on miRNA expression since several studies showed that lithium, haloperidol, or valproate induced changes of the miRNA profiles in brain.”

This, of course, is why preventive medicine involves interfacing with the environment in a language that the body understands based on millions of years of co-evolution.

Gamechanger #3: Belief

When I was in training, the placebo effect was framed as a nuisance factor that needed to be controlled for. I now understand that the placebo effect doesn’t mean that you were fooled or tricked. It doesn’t mean you’re making it up or that you’re gullible. It means that a complex physiologic cascade of events was kicked off by your experience of taking a pill with the promise of relief.

It is rapidly being characterized as the most important driver of outcomes in everything from psychiatry to surgery.

My research on the placebo effect has helped me to understand that psychiatric medications, and specifically antidepressants, are more risk than benefit, and that I cannot achieve meaningful outcomes with patients who do not fundamentally believe that their bodies can heal.

How could it be that belief is this important?

Dr. Candace Pert, the pioneering researcher credited with the discovery of the opiate receptor, has debunked the Cartesian dualism that for hundreds of years has put the mind out of the realm of the body. She also challenged the notion that the mind is something that merely relates to the body. The mind, per her conclusions, is the body.

In fact, she used the language of the bodymind and elucidated how neuropeptides travel around the body encoding emotion in different tissues and organs. The shape of these peptides, or their conformation, further transmitted information to receipient cells.  All of the sudden, informational transfer takes on another dimension – vibration.

Another pioneer of the role of belief in cellular physiology, Dr. Bruce Lipton was several decades ahead of his time in establishing the role of environment and belief in the body’s physiology. His work has decentralized the nucleus (where the genes are housed), and focused on the cell membrane as an information-processing interface with the environment.

Taken together, this research all seems to suggest that we are a product of our energetic experience in the context of a greater whole. Even physics is mirroring this with the emergence of theories like Rupert Sheldrake’s morphic resonance, which suggests that collective experiences set a potential template for individual experiences in a type of memory transfer that has little to do with genes.

We are not random genes driving a purposeless life until we die.

It appears that human experience is not as it has been previously framed and echoed by philosopher Alan Watts – flesh robots on a dead rock in the middle of nowhere. When the human experience is reduced in this way, it’s most essential elements are denied – beauty, spirit, meaning.

In fact, human experience is the universe manifested at one point. It is the emergent properties of many, infinitely complex and interfacing systems. It is fundamentally sacred, larger than our will, and gently demanding of our humility.

This is the teleologic perspective – one in which the purpose rather than the cause is the explanation of phenomena. I reflect on this when I consider how adaptable our bodies are – in real time, within hours – and how we have not adapted fully to the lifestyles we have felt entitled to over the past 100 years. We live from our egos with total disregard for nature, each other, and our own bodily vessels. And we are sicker than we have ever been, from cradle to grave.  It seems that we are not “meant” to adapt to this way of living and we are reminded of this through the signals of illness. We are called back to the Continuum through our anxiety, depression, and illness. We are reminded that we haven’t figured it out, that science is not and cannot be used merely as a tool for control, and that consciousness as an emergent property of our physiologic web, is a gift.

 

The fairest thing we can experience is the mysterious. It is the fundamental emotion which stands at the cradle of true art and true science…the mystery of the eternity of life, and the inkling of the marvellous structure of reality, together with the single-hearted endeavor to comprehend a portion, be it ever so tiny, of the reason that manifests itself in nature. – Einstein

How Much Protein Can Your Muscles Absorb In One Sitting?


How Much Protein Can Your Muscles Absorb In One Sitting?

It would seem logical that the more protein you pack away during a meal, the bigger your muscles would grow.

But your body doesn’t work that way. There’s a certain amount of protein your muscles can absorb in one sitting.

Fast Bodyweight Workouts From Men’s Health That Are So Intense, They Rip Away Body Fat!

“Skeletal muscle protein synthesis is maximized by 25 to 35 grams of high-quality protein during a meal,” says Doug Paddon-Jones, Ph.D., a professor of nutrition and metabolism at the University of Texas Medical Branch.

“Protein synthesis” is basically a fancy way of saying “building and repairing muscle.” Exercise creates microtears in your muscles. The harder you work, the more tears. Protein helps repair these tears, causing your muscles to grow bigger and stronger.

If your muscles receive fewer than 25 grams of protein in a sitting, however, muscle tears brought on by exercise persist due to lack of building materials.

But if your muscles receive more than 35 grams of protein, they have all the building materials they need and the protein goes to other parts of your body—or into the toilet. (For a deep dive into workout nutrition, check out What and When You Should Eat to Build Muscle.)

The magic amount of protein your muscles are capable of absorbing during a meal seems to be about 25 to 35 grams.

You could get that from:

1 cup cottage cheese (28 grams protein)
1 cup Greek yogurt plus a handful of nuts (25g)
A palm size portion of steak, fish and/or poultry (28g)
3 whole eggs + 3 egg whites (27g)
1 scoop of whey protein (25 g) (Use the scoop in any of these 20 Healthy, Protein-Packed Shakes.)

So chewing through an entire side of beef may not benefit your muscles any more than taking down a smaller portion of tenderloin.

In fact, if you’re piling your plate with too much protein, you might be pushing other vital nutrients out of your diet from foods such as vegetables, fruits, healthy fats, and whole grains, that can help with muscle recovery and weight loss.

And you don’t have to down a huge shake or omelet after a workout. Studies on protein timing show muscles’ elevated sensitivity to protein lasts at least 24 hours, says Alan Aragon, M.S., Men’s Health nutrition advisor.

In fact, one 2012 review study by McMaster University showed that muscle protein synthesis may continue for 24 to 48 hours post-workout. “The effect is higher immediately after exercise and diminishes over time, but that certainly doesn’t imply a magical window closes after an hour,” says Aragon.

Related: The Best Exercise and Diet Plan For Losing Weight While Gaining Muscle

What matters most is your total protein intake throughout the day. Reframe how you think about protein, especially if you’re trying to build muscle. Instead of eating 60 grams of protein during three meals a day, trying eating 25 to 35 grams of protein four or more times a day. Consume one of these meals within one to two hours pre- and –post workout so you cover your bases, says Aragon.