Warped sense of humour could be ‘sign of impending dementia’


Research has found dementia patient’s friends and family noticed a distinct change in their loved one’s sense of humour.

An increasingly dark or twisted sense of humour could be an early warning sign of impending dementia, according to experts.

The results have appeared in the Journal of Alzheimer’s Disease, which was carried out by University College London.

Dr Camilla Clark recruited 48 patients with frontotemporal dementia from their dementia clinic at University College London. The patient’s friends and family were asked to rate their friend or relative’s enjoyment of different kinds of comedy.

These included slapstick comedy such as Mr Bean, satirical comedy such as Yes, Minister or absurdist comedy such as Monty Python and examples of inappropriate humour.  Dr Clark found that the dementia patients preferred slapstick humour to satirical, when compared to 21 healthy people of a similar age.

Nearly all of those asked, said that they had noticed a change in the patient’s humour within the previous nine years before being diagnosed with dementia. The changes included a darker sense of humour and laughing at tragic events in the news or their personal lives.

Dr Clark said: “These were marked changes – completely inappropriate humour well beyond the realms of even distasteful humour. For example, one man laughed when his wife badly scalded herself”.

Dr Simon Ridley, of Alzheimer’s Research UK, said anyone concerned about changes in their behaviour should speak to their GP.

“While memory loss is often the first thing that springs to mind when we hear the word dementia, this study highlights the importance of looking at the myriad different symptoms that impact on daily life and relationships”, he said.

“A deeper understanding of the full range of dementia symptoms will increase our ability to make a timely and accurate diagnosis”.

Frontotemporal dementia is only one type of dementia, and is one of the rarer types.

Experts say that more research is needed to help identify more clearly when changes in humour can signify the beginnings of dementia.

Happy Deepawali.


Dear all my blog readers, followers and subscribers, I wish you all a very happy, safe and Eco friendly the Festival of Deepawali.

Dr Chandan
Blog administrator

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Invention of forge-proof ID to revolutionise security


Invention of forge-proof ID to revolutionise security
Electronically stimulating an atomically random system, represented above by a key, produces a unique pattern that can be used for authentication or identification purposes whilst being fundamentally unclonable.

Scientists have discovered a way to authenticate or identify any object by generating an unbreakable ID based on atoms.

The technology, which is being patented at Lancaster University and commercialised through the spin-out company Quantum Base, uses next-generation to enable the unique identification of any product with guaranteed security.

The research published today in Nature’s Scientific Reports uses atomic-scale imperfections that are impossible to clone as they comprise the unmanipulable building blocks of matter.

First author Jonathan Roberts, a Lancaster University Physics PhD student of the EPSRC NOWNANO Doctoral Training Centre, said: “The invention involves the creation of devices with unique identities on a nano-scale employing state-of-art quantum technology. Each device we’ve made is unique, 100% secure and impossible to copy or clone.”

Current solutions such as anti-counterfeit tags or password-protection base their security on replication difficulty, or on secrecy, and are renowned for being insecure and relatively easy to forge. For example, current anti-counterfeiting technology such as holograms can be imitated, and passwords can be stolen, hacked and intercepted.

The ground-breaking atomic-scale devices do not require passwords, and are impervious to cloning, making them the most secure system ever made. Coupled with the fact that they can be incorporated into any material makes them an ideal candidate to replace existing authentication technologies.

Writing in Nature’s Scientific Reports, the researchers said: “Simulating these structures requires vast computing power and is not achievable in a reasonable timescale, even with a quantum computer. When coupled with the fact that the underlying structure is unknown, unless dismantled atom-by-atom, this makes simulation extremely difficult.

“While inhomogeneity in the fabrication of nanostructures often leads to unpredictable behaviour of the final device, which is normally undesirable, we have proposed and demonstrated a potential use for the quantum behaviour of atomically irreproducible systems.”

The reported Q-ID device, which uses an electronic measurement with CMOS compatible technology, can easily be integrated into existing chip manufacturing processes, enabling cost effective mass-production. The new devices also have many additional features such as the ability to track-and-trace a product throughout the supply chain, and individual addressability, allowing for marketing and quality control at the point of consumption.

Dr Robert Young, the research leader at Lancaster University and co-founder of Quantum Base said: “One could imagine our devices being used to identify a broad range of products, whether it is authentication of branded goods, SIM cards, important manufacturing components, the possibilities are endless.”

The use of inexpensive nanomaterials and their ability to be produced in large quantities has resulted in smaller, more power efficient devices that are future-proof to cloning.

Phil Speed co-founder of Quantum Base said “Q-IDs markedly increase the security gap between the good guys and the bad guys; this is truly a step change in authentication and authorisation. Lancaster and Quantum base have created devices that are the smallest, the most secure and the cheapest possible today and we are looking forward to talking to prospective markets and customers alike to bring this new, cutting edge, great British technology into mass market adoption.”

Scientifically Confirmed: Turmeric Is More Effective Than These 14 Prescription Drugs


Turmeric is a bright yellow colored spice, acquired from a tropical plant “Curcuma Longa”, originating from the ginger family.

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It is most common for the region of southwest India and Indonesia, where it is considered to be a sacred spice and is deeply associated with the culture of the Indian people.

Every Indian consumes 2 grams of turmeric each day.

Recently, turmeric has become a rather popular spice and has had a significant increase in consumption in Japan as well as in the West.

The Anti-inflammatory Effects of Turmeric

Studies have shown that turmeric has the strongest anti-inflammatory effect in the plant world. Curcumin (the main ingredient in turmeric) inhibits (stops) the enzyme activity of COX-2 (cyclooxygenase), which is responsible for the creation of molecules that cause inflammation.

turmeric

We know how inflammation comes in the same package with a large number of diseases, starting from inflammatory conditions of the skin (psoriasis, dermatitis), joint inflammation, autoimmune diseases (allergy, rheumatoid arthritis, psoriasis, collagen…), mucosa damage of the gastrointestinal tract where it can cause ulcers, polyps, and later carcinoma.

The effect of turmeric is very important in light of the latest results as a good substitute for synthetic anti-inflammatory agents (corticosteroids) that cause serious and permanent side effects.

Turmeric is one of the most thoroughly researched plants today. Its medicinal properties and components (especially curcumine) has been the subject of more than 5,600 published reviews and biomedical research. In fact, in the five-year research project on the “sacred plant” scientists discovered more than 600 potential preventive and therapeutic applications, as well as 175 different beneficial physiological effects.

Given the number and the density of studies carried out on this important spice, it is not surprising that a growing number of studies have found that turmeric is more useful than a variety of conventional drugs, including:

  • Lipitor / atorvastatin (cholesterol drug):  a 2008 survey published in the R & D journal for drugs revealed that a standardized preparation of the curcuminoids from turmeric worked better than Lipitor on endothelial dysfunction, underlying pathology of the blood vessels that drives atherosclerosis, reducing inflammation and oxidative stress in patients with type 2 diabetes.turmeric paste
  • Corticosteroids (steroid drugs): A study published back in 1999 in thePhytotherapy Research journal has shown that the primary polyphenol in turmeric, saffron pigment known as curcumina, had a better impact than steroids on the management of chronic anterior uveitis, an inflammatory eye disease.
  • Prozac / Fluoxetine & Imipramine (antidepressant): A study published in 2011 in theActa Pharmaceutica Polonie journal revealed that turmeric worked better compared to both drugs in reducing depressive behavior in animals.
  • Aspirin (blood thinner): In vitro and ex vivo studies, published in 1986 in theArzneimittelforschung journal found that turmeric has anti-platelet and prostacyclin modulating effect in relation to aspirin, which means that it can be used in patients prone to vascular thrombosis and in anti- -arthritis therapy.
  • Anti-inflammatory drugs: A study published in 2004 in the Oncogene journal, found that turmeric (same as resveratrol) was more effective than aspirin, ibuprofen, sulindac, phenylbutazone, Naproxen, Indomethacin, diclofenac, dexamethasone, celecoxib, and Tamoxifen.
  • Oxaliplatin (chemotherapeutic drugs): In 2007 the International Cancer Journal showed that turmeric could be compared with oxaliplatin as an anti proliferative drug in colorectal cell lines.
  • Metformin (diabetes drug): The Biochemistry and Biophysical journal back in 2009 published a study that examined how turmeric can be valuable in the treatment of diabetes. They found that it activates AMPK (which increases glucose uptake) and suppresses gluconeogenic gene expression (which suppresses the formation of glucose liver) in hematoma cells. Interestingly, they found that turmeric is from 500 times to 100,000 times (in the form known as tetrahydrocurcuminoids (THC)) more potent than metformin in activating AMPK and its further targeted acetyl-CoA carboxylase (ACC).

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Another way that turmeric and its constituent parts reveal their extraordinary healing properties was shown in the study on drugs for resistant and multi-drug resistant tumors.

54 studies found that turmeric may cause the death of cancer cells or weaken the resistant cancer cell lines with conventional treatment.

Given the strong footprint from turmeric (curcumine) research, and also having been used as food and medicine in a wide range of cultures, for thousands of years, a strong argument can be made for the use of turmeric as an alternative medicine or a catalyst for the treatment of cancer.

Use organic (non-irradiated) turmeric, in lower culinary doses on a daily basis, but never use greater doses later in life given the fact it may be the basis for a serious illness.

Ancient river network discovered buried under Saharan sand


Radar images of the Mauritanian desert have revealed a river stretching for more than 500km and suggest plants and wildlife once thrived there

A radar image of the discovered paleo-rivers. Water may last have coursed through the newly discovered network’s channels 5,000 years ago.
A radar image of the discovered paleo-rivers. Water may last have coursed through the newly discovered network’s channels 5,000 years ago. Photograph: Philippe Paillou

A vast river network that once carried water for hundreds of miles across Western Sahara has been discovered under the parched sands of Mauritania.

Radar images taken from a Japanese Earth observation satellite spotted the ancient river system beneath the shallow, dusty surface, apparently winding its way from more than 500km inland towards the coast.

The buried waterway may have formed part of the proposed Tamanrasett River that is thought to have flowed across parts of Western Sahara in ancient times from sources in the southern Atlas mountains and Hoggar highlands in what is now Algeria.

The French-led team behind the discovery believe the river carried water to the sea during the periodic humid spells that took hold in the region over the past 245,000 years. Water may last have coursed through the channels 5,000 years ago.

The river would have helped people, plants and wildlife to thrive in what is now desert land, and would have carried nutrients crucial for marine organisms far into the sea. Were it still flowing today, the river system would rank 12th among the largest on Earth, the researchers write in the journal Nature Communications.

Images taken from the satellite revealed that the hidden river beds aligned almost perfectly with a huge underwater canyon that extends off the coast of Mauritania into waters more than three kilometres deep. First mapped in 2003, the Cap Timiris Canyon is 2.5km wide and a kilometre deep in places.

The outlines and the main course of the proposed Tamanrasett River are drawn in blue and grey, respectively. The newly identified river and the Cap Timiris Canyon are in dark blue on the far left of the map.
Pinterest
The outlines and the main course of the proposed Tamanrasett River are drawn in blue and grey, respectively. The newly identified river and the Cap Timiris Canyon are in dark blue on the far left of the map. Photograph: Nature Communications

Russell Wynn at the National Oceanography Centre in Southampton was among the researchers who created the first 3D map of the canyon from the German Meteor research vessel. Sediment cores brought up from the canyon bottom contained fine-grained river-borne particles that suggested a massive river had first formed, and later fed into, the deep channel carved into the continental shelf.

“It’s a great geological detective story and it confirms more directly what we had expected. This is more compelling evidence that in the past there was a very big river system feeding into this canyon,” said Wynn, who was not involved in the latest study. “It tells us that as recently as five to six thousand years ago, the Sahara desert was a very vibrant, active river system.”

In full flow, the river would have carried organic material from the land out into the ocean, where it sustained a rich ecosystem of filter feeders and other organisms in the canyon. But the river was destructive too, occasionally sending rapid, turbulent rushes of water and sediment down the canyon. Similar flows are still active off the coast of Taiwan today, and hold enough power to destroy submarine cables and other infrastructure.

“People sometimes can’t get their head around climate change and how quickly it happens. Here’s an example where within just a couple of thousand years, the Sahara went from being wet and humid, with lots of sediment being transported into the canyon, to something that’s arid and dry,” Wynn said.

VATS for Removal of Para-Aortic Metallic Foreign Body


This is the case of a 24-year-old male patient who was involved in a blast injury. Among his multiple traumas was a metallic foreign body abutting the aorta in the left pleural cavity associated with the small hemothorax. Indications to remove the shrapnel included: proximity of the metallic shrapnel to a major vessel, shrapnel larger than 2 cm, and sharp/jagged edges. VATS was utilized to extract the bullet from the pleural cavity. In the author’s view, the use of VATS in a hemodynamically stable trauma patient is both safe and effective in removing metallic foreign bodies and shrapnel from the pleural cavity.

watch the video. URL:https://youtu.be/9STFTgSqbMY

HAPPY DEEPAWALI.


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HAPPY DEEPAWALI, THE FESTIVAL OF LIGHTS TO ALL MY BLOG READERS, BLOG SUBSCRIBERS AND FOLLOWERS.

DR CHANDAN, NEW DELHI, INDIA.

BLOG ADMINISTRATOR.

Humans are ‘designed’ to get over a broken heart.


We’ve all been there, the one you thought you couldn’t live without, leaves you broken hearted, and you feel like you will never get over it. Though predictably, with enough time, the heartache fades. Researchers at the Saint Louis University (SLU) have found that humans may be designed to fall out of love so we can move on to new romantic relationships.

Epidemiologist Dr. Brian Boutwell of SLU says it’s a part of natural selection:

The ability to sever that affection, and attraction, and attachment under certain circumstances would have benefited our ancestors in kind of the ancestral path in our lineage.

Boutwell suggests that human beings have a mechanism builded into our brain that is specifically designed by natural selection to help us through rough times in our lives, suggesting the pain will fade with time. The ability to end a relationship and begin a new one is influenced by genetic and environmental factors. Some people might have more problems with moving on than others, and for some falling out of love is easier.

The reasons for ending a relationship are different for men and women. More often men ended a relationship if their partner was sexually unfaithful, whilst women would often end their relationships if their partner was emotionally unfaithful. The researchers state that this is also due to evolution. Men are attuned to avoid raising children not their own, whilst women are looking for partners who will provide for them and their offspring.

Falling out of love and cocaine addiction

By taking MRI scans, Boutwell and his colleagues also found that the same area of your brain shows increased neuronal activity when you are dealing with heartache, as when it gets stimulated by cocaine use. Boutwell further said that a cocaine addict going through the process of beating his addiction could experience the same sort of emotions as when people fall out of love. Making a conscious effort to quite a harmful habit could therefore be similar to trying to move on after a break-up.

Chlamydia-Caused Eye Infections Are More Extensive Than Scientists Thought


RESEARCHERS SPY THE BACTERIA LURKING IN NEW REGIONS OF THE EYE

Ocular infection with Chlamydia trachomatis may be worse than believed.

When we hear the word, “Chlamydia,” we tend to think of a sexually transmitted infection. Although the bacterium responsible for the disease,Chlamydia trachomatis, has been isolated from the genital regions of bothwomen and men, this region of the body isn’t the only place where infection can happen. In fact, even the name of the bacterium suggests a more nefarious site for troubles: the eye.

C. trachomatis was first isolated from epithelial tissues of the eye causing a condition known as trachoma. The condition was known to start off as a regular form of conjunctivitis. Without proper treatment, the symptoms could lead to blindness. Over time, improvements to health, hygiene, and environmental cleanliness helped to lessen the burden of the disease and prompted health officials to suggest an end to this type of infection could be possible.

However, the pathogenesis of C. trachomatis is more complex than a standard infection. Because the bacterium is an obligate intracellular pathogen, it must live inside a human cell in order to thrive and reproduce. This offers the chance to develop persistence and recurrence.

When the bacterium was found, the only ocular cell type thought to be infected was the conjunctive epithelium. However, due to the threat of persistent infection, other epithelial cells in the eye needed to be given attention. This included all aspects of ocular anatomy including the lens, the cornea, and the iris.

Now there’s another potential target for the bacterium. Last week, a group of Russian researchers revealed for the first time that C. trachomatis can infect a group of cells not thought to be involved in infection. However, based on the results, it appears there may be a larger niche of susceptible cells than believed.

The researchers focused on a group of cells known as retinal pigment epithelium, or RPE. It is part of the blood/retina barrier and works to protect the retina over one’s lifetime. The cells also help to increase optical quality by absorbing scattered light using a pigmented wall. Plus, the RPE maintains cellular growth and immune balance. The cells accomplish this by secreting a variety of chemicals including growth factors. They also act as nutrient transporters to ensure the subretinal space and photoreceptors are kept nourished and hydrated. As might be expected, any deficiencies in RPE integrity and/or function could mean significant troubles for the region and ultimately, for sight.

The experiments themselves were relatively straightforward. The team gathered RPE cells from cadavers and then incubated them in growth media. The numbers of the cells grew high enough to allow for the experimental infections. At this stage, the bacteria were added. After as little as one day, infection could be seen, although it wasn’t entirely uniform. But after a few days, there was little doubt as to the fate of the RPE cells. Not only were they infected, but they also allowed the bacteria to grow, multiply, and spread.

With infection confirmed, the researchers wanted to determine whether there were any adverse effects on the protective role of the cells. Essentially, they wanted to know if a patient would risk losing some or all of the retinal function with infection. Thankfully, there appeared to be little change in the formation of growth factors and other molecules necessary for proper retina maintenance. However, the results did not offer only good news.

After infection occurred, the cells began to produce a larger amount of collagen. An increase in this molecule can lead to a variety of troubles including vitreoretinopathy and retinal detachment. In 2011, the latter was actually seen in a clinical case and sure enough, C. trachomatis was isolated from the retinal region.

For the authors, this revelation is only the first stage of their research. Showing RPE can become infected with the bacteria and also cause possible side effects offers merely a foundation. Now they can move forward in their research with the hopes of dealing with this bacterial infection in the future.

For example, the team found an altered immune response from infected cells. This could damage the delicate balance of immunity in the area and contribute to significant consequences. By honing in on these immunological markers, treatments may be tested in the future to figure out how to slow disease progression and help to save a person’s sight.

Africa is the Western world’s testing ground for microchip implants, weaponized viruses and experimental vaccines


The African continent continues to be used by Western powers as a testing ground for some pretty heinous things, the latest of which appears to be microchip implants. This is a concept privacy advocates in the U.S. have long warned about.

According to Patriot Truther and BusinessWire, credit card company Visa recently introduced a new specification for the use of biometrics with chip card transactions that can enable palm, iris, facial or voice biometrics. The first-of-its-kind technology is designed to be incorporated for use with the EMV® (Europay, MasterCard, Visa) chip industry standard to ensure the cards can be used around the globe.

With current surveillance technology, the biometric cards will also be traceable and trackable, as will the biometric data. This information will be valuable to merchandising corporations, technology companies and, of course, governments.

“There is increasing demand for biometrics as a more convenient and secure alternative to signatures or PINs, especially as biometrics technologies have become more reliable and available,” claimed Mark Nelsen, senior vice president of Risk Products and Business Intelligence for Visa Inc. “However, to support wide adoption, it is equally important that solutions are scalable and based on open standards. Building on the EMV chip standard provides a common, interoperable foundation, as well as encourages innovation in cutting-edge biometric solutions.”
Africa

More personal data to track

The biometrics are being sold to customers as merely being helpful, modern ways to prevent fraud and help people pay “securely.” The architecture of the design by Visa will enable fingerprints, for example, to be “securely” accepted by a biometric reader, encrypted and then validated.

“Issuers can optionally validate the biometric data within their secure systems for transactions occurring in their own environments, such as their own ATMs,” BusinessWire reported.

Absa Bank, which is a wholly-owned subsidiary of Barclays Africa Group, will become the first to use the new cards.

This comes on the heels of earlier reports stating that Wells Fargo Bank also wants to begin using “secure” biometric card technology.

Not only are such biometrics likely to be tracked, but as more of our personal information is cataloged online and stored in “clouds,” it will become more vulnerable to hacking and cyber theft.

The biometrics “test” in Africa is just the latest evil committed against the people of that continent. As noted in this open letter published by the Liberian Observer, “testing” of the Ebola virus had been occurring in Africa for years before the most recent outbreak.

Laced vaccines, Ebola as a weapon

As noted by our editor Mike Adams, the Health Ranger, in this Oct. 22, 2014 story:

The idea that Ebola might be a genetically engineered bioweapon was openly discussed by a top Liberian scientist named Dr. Cyril Broderick, who published a front-page story in the Liberian Observer containing the astonishing statement, “Ebola is a genetically modified organism (GMO).”

…Broderick goes on to assert that the U.S. Dept. of Defense has been using African women and children for bioweapons experiments.

In his own words, he talks about “…the existence of an American Military-Medical-Industry that conducts biological weapons tests under the guise of administering vaccinations to control diseases and improve the health of black Africans overseas.”

Speaking of vaccines and Africa, Adams reported the following month that “tetanus vaccines given to millions of young women in Kenya have been confirmed by laboratories to contain a sterilization chemical that causes miscarriages” – a cruel and subversive act orchestrated by UNICEF and the World Health Organization (WHO).

“We sent six samples from around Kenya to laboratories in South Africa. They tested positive for the HCG antigen,” Dr. Muhame Ngare of the Mercy Medical Centre in Nairobi told LifeSiteNews. “They were all laced with HCG.”

Learn more: http://www.naturalnews.com/051913_African_human_testing_biometric_cards_personal_data_tracking.html#ixzz3rNw0KlFf