This Interview With Nikola Tesla From 1899 Reveals His Extraordinary Personality


Very interesting interview Nikola Tesla and John Smith in which he said: Everything is the Light. In one of its rays is the fate of nations, each nation has its own ray in that great light source, which we see as the Sun. And remember: no one man that existed did not die.

JOURNALIST: Mr. Tesla, you have gained the glory of the man who got involved in the cosmic processes. Who are you, Mr. Tesla?
TESLA: It is a right question, Mr. Smith, and I will try to give you the right answer to it.

JOURNALIST: Some say you’re from the country of Croatia, from the area called Lika, where together with the people are growing trees, rocks and starry sky. They say that your home village is named after the mountain flowers, and that the house, where you were born, is next to the forest and the church.
TESLA: Really, all it true. I’m proud of my Serbian origin and my Croatian homeland.

JOURNALIST: Futurists say that the Twenty-and Twenty First Century was born in head of Nikola Tesla. They celebrate conversely magnetic field and sing hymns to Inductions engine. Their creator was called the hunter who caught the light in his net from the depths of the earth, and the warrior who captured fire from heaven. Father of alternating current will make the Physics and Chemistry dominate half the world. Industry will proclaim him as their supreme saint, a banker for the largest benefactors. In the laboratory of Nikola Tesla for the first time is broken atom. There is created a weapon that causes the earthquake vibrations. There are discovered black cosmic rays. Five races will pray to him in the Temple of the future, because they had taught a great secret that Empedocles elements can be watered with the life forces from the ethers.
TESLA: Yes, these are some of my most important discoveries. I’m a defeated man. I have not accomplished the greatest thing I could.

JOURNALIST: What is it, Mr. Tesla?
TESLA: I wanted to illuminate the whole earth. There is enough electricity to become a second sun. Light would appear around the equator, as a ring around Saturn.
Mankind is not ready for the great and good. In Colorado Springs I soaked the earth by electricity. Also we can water the other energies, such as positive mental energy. They are in the music of Bach or Mozart, or in the verses of great poets. In the Earth’s interior, there are energy of Joy, Peace and Love. Their expressions are a flower that grows from the Earth, the food we get out of her and everything that makes man’s homeland. I’ve spent years looking for the way that this energy could influence people. The beauty and the scent of roses can be used as a medicine and the sun rays as a food. Life has an infinite number of forms, and the duty of scientists is to find them in every form of matter. Three things are essential in this. All that I do is a search for them. I know I will not find them, but I will not give up on them.

JOURNALIST: What are these things?
TESLA: One issue is food. What a stellar or terrestrial energy to feed the hungry on Earth? With what wine watered all thirsty, so that they can cheer in their heart and understand that they are Gods?
Another thing is to destroy the power of evil and suffering in which man’s life passes! They sometimes occur as an epidemic in the depths of space. In this century, the disease had spread from Earth in the Universe.
The third thing is: Is there an excess Light in the Universe? I discovered a star that by all the astronomical and mathematical laws could disappear, and that nothing seems to be modified. This star is in this galaxy. Its light can occur in such density that fits into a sphere smaller than an apple, a heavier than our Solar System. Religions and philosophies teach that man can become the Christ, Buddha and Zoroaster. What I’m trying to prove is wilder, and almost unattainable. This is what to do in the Universe so every being is born as Christ, Buddha or Zoroaster.
I know that gravity is prone to everything you need to fly and my intention is not to make flying devices (aircraft or missiles), but teach individual to regain consciousness on his own wings … Further; I am trying to awake the energy contained in the air. There are the main sources of energy. What is considered as empty space is just a manifestation of matter that is not awakened. No empty space on this planet, nor in the Universe.. In black holes, what astronomers talk about, are the most powerful sources of energy and life.

JOURNALIST: On the window of your room in hotel “Valdorf-Astoria”, on the thirty-third floor, every morning, the birds arrive.
TESLA: A man must be sentimental towards the birds. This is because of their wings. Human had them once, the real and visible!

JOURNALIST: You have not stopped flying since those distant days in Smiljan!
TESLA: I wanted to fly from the roof and I fell: Children’s calculations could be wrong. Remember, the youth wings have everything in life!

JOURNALIST: Have you ever married? It is not known that you have affection for love or for a woman. Photos from the youth show you were handsome man.
TESLA: Yes. I did not. There are two views: a lot affection or not at all. The center serves to rejuvenate human race. Women for certain people nurtures and strengthen its vitality and spirit. Being single does the same to other people. I chose that second path.

JOURNALIST: Your admirers are complaining that you attacking relativity. The strange is your assertion that the matter has no energy. Everything is imbued with energy, where it is?
TESLA: First was energy, then matter.

JOURNALIST: Mr. Tesla, it’s like when you said that you were born by your father, and not on you.
TESLA: Exactly! What about the birth of the Universe? Matter is created from the original and eternal energy that we know as Light .It shone, and there have been appear star, the planets, man, and everything on the Earth and in the Universe. Matter is an expression of infinite forms of Light, because energy is older than it. There are four laws of Creation. The first is that the source of all the baffling, dark plot that the mind cannot conceive, or mathematics measure. In that plot fit the whole Universe. The second law is spreading a darkness, which is the true nature of Light, from the inexplicable and  it’s transformed into the Light. The third law is the necessity of the Light to become a matter of Light. The fourth law is: no beginning and no end; three previous laws always take place and the Creation is eternal.

JOURNALIST: In the hostility to the theory of relativity you go so far, that you hold lectures against its Creator at your birthday parties..
TESLA: Remember, it is not curved space, but the human mind which cannot comprehend infinity and eternity! If relativity has been clearly understood by its Creator, he would gain immortality, even yet physically, if he is pleased.
I am part of a light, and it is the music. The Light fills my six senses: I see it, hear, feel, smell, touch and think. Thinking of it means my sixth sense. Particles of Light are written note. O bolt of lightning can be an entire sonata. A thousand balls of lightening is a concert.. For this concert I have created a Ball Lightning, which can be heard on the icy peaks of the Himalayas.
About Pythagoras and mathematics a scientist may not and must not infringe of these two. Numbers and equations are signs that mark the music of the spheres. If Einstein had heard these sounds, he would not create theories of relativity. These sounds are the messages to the mind that life has meaning, that the Universe exists in perfect harmony, and its beauty is the cause and effect of Creation. This music is the eternal cycle of stellar heavens. The smallest star has completed composition and also, part of the celestial symphony. The man’s heartbeats are part of the symphony on the Earth. Newton learned that the secret is in geometric arrangement and motion of celestial bodies. He recognized that the supreme law of harmony exists in the Universe. The curved space is chaos, chaos is not music. Einstein is the messenger of the time of sound and fury.

JOURNALIST: Mr. Tesla, do you hear that music?
TESLA: I hear it all the time. My spiritual ear is as big as the sky we see above us. My natural ear I increased by the radar. According to the Theory of Relativity, two parallel lines will meet in infinity. By that Einstein’s curved will straighten. Once created, the sound lasts forever. For a man it can vanish, but continues to exist in the silence that is man’s greatest power. No, I have nothing against Mr. Einstein. He is a kind person and has done many good things, some of which will become part of the music. I will write to him and try to explain that the ether exists, and that its particles are what keep the Universe in harmony, and the life in eternity.

JOURNALIST: Tell me, please, under what conditions Angel adopt on the Earth?
TESLA: I have ten of them. Keep good records vigilant.

JOURNALIST: I will document all your words, Dear Mr. Tesla.
TESLA: The first requirement is a high awareness of its mission and work to be done. It must, if only dimly, exist in the early days. Let us not be falsely modest; Oak knows that it is oak tree, a bush beside him being a bush. When I was twelve, I have been sure I will get to Niagara Falls. For most of my discoveries I knew in my childhood that I will achieve them, although not entirely apparent … The second condition to adapt is determination. All that I might, I finished.

JOURNALIST: What is the third condition of adjustment, Mr. Tesla?
TESLA: Guidance for all the vital and spiritual energies in labor. Therefore purification of the many effects and needs that man has. I therefore have not lost anything, but just gained.
So I enjoyed every day and night. Write down: Nikola Tesla was a happy man…
The fourth requirement is to adjust the physical assembly with a work.

JOURNALIST: What do you mean, Mr. Tesla?
TESLA: First, the maintenance of the assembly. Man’s body is a perfect machine. I know my circuit and what’s good for him. Food what nearly all people eat, to me it is harmful and dangerous. Sometimes I visualize that chefs in the world are all in conspiracy against me … Touch my hand.

JOURNALIST: It was cold.
TESLA: Yes. Bloodstream can be controlled, and many processes in and around us. Why are you frightened young man?

JOURNALIST: It’s a story that Mark Twain wrote a mysterious stranger, that wonderful book of Satan, inspired by you.
TESLA: The word “Lucifer” is more charming. Mr. Twain likes to joke. As a child I was healed once by reading his books. When we met here and told him about, he was so touched that he cried. We became friends and he often came to my lab. Once he requested to show him a machine that by vibration provokes a feeling of bliss. It was one of those inventions for entertainment, what I sometimes like to do. I warned Mr. Twain as not to remain under these vibrations. He did not listen and stayed longer. It ended by being, like a rocket, holding pants, darted into a certain room. It was a diabolically funny, but I kept the seriousness.
But, to adjust the physical circuit, in addition to food, dream is very important . From a long and exhausting work, which required superhuman effort, after one hour of sleep I’d be fully recovered. I gained the ability to manage sleep, to fell asleep and wake up in the time which I have designated. If I do something what I do not understand, I force myself to think about it in my dream, and thus find a solution.
TESLA: The fifth condition of adjustment is memory. Perhaps in the most people, the brain is keeper of knowledge about the world and the knowledge gained through the life. My brain is engaged in more important things than remembering, it is picking what is required at a given moment. This is all around us. It should only be consumed. Everything that we once saw, hear, read and learn, accompanies us in the form of light particles. To me, these particles are obedient and faithful. Goethe’s Faust, my favorite book, I learned by heart in German as a student, and now it can all recite. I held my inventions for years  ‘in my head ”, and only then I realized them.

JOURNALIST: You often mentioned the power of visualization.
TESLA: I might have to thank to visualization for all that I invented. The events of my life and my inventions are real in front of my eyes, visible as each occurrence or the item. In my youth I was frightened of not knowing what it is, but later, I learned to use this power as an exceptional talent and gift. I nurtured it, and jealously guarded. I also made corrections by visualization on most of my inventions, and finish them that way, by visualization I mentally solve complex mathematical equations. For that gift I have, I will receive rank High Lama in Tibet.
My eyesight and hearing are perfect and, dare to say, stronger than other people. I hear the thunder of a hundred fifty miles away, and I see colors in the sky that others cannot see. This enlargement of vision and hearing, I had as a child. Later I consciously developed.

JOURNALIST: In youth you have several times been seriously ill. Is it a disease and a requirement to adapt?
TESLA: Yes. It is often the result of a lack of exhaustion or vital force, but often the purification of mind and body from the toxins that have accumulated. It is necessary that a man suffers from time to time. The source of most disease is in the spirit. Therefore the spirit and can cure most diseases. As a student I got sick of cholera which raged in the region of Lika. I was cured because my father finally allowed me to study technology, which was my life. Illusion for me was not a disease, but the mind’s ability to penetrate beyond the three dimensions of the earth. I had them all my life, and I have received them as all other phenomena around us. Once, in childhood, I was walking along the river with Uncle and said: ”From the water will appear the trout, I’ll throw a stone and it is cut.” That’s what happened. Frightened and amazed, his uncle cried: ”Bade retro Satan’s!” He was an educated and he spoke in Latin … I was in Paris when I saw my mother’s death. In the sky, full of light and music floated are wonderful creatures. One of them had a mother’s character, who was looking at me with infinite love. As the vision disappeared, I knew that my mother died.

JOURNALIST: What is the seventh adjustment, Mr. Tesla?
TESLA: The knowledge of how the mental and vital energy transform into what we want, and achieve control over all feelings. Hindus call it Kundalini Yoga. This knowledge can be learned, for what they need many years or is acquired by birth. The most of them I acquired by birth. They are in the closest connection with a sexual energy that is after the most widespread in the Universe. The woman is the biggest thief of that energy, and thus the spiritual power. I’ve always knew that and was alerted. Of myself I created what I wanted: a thoughtful and spiritual machine.

JOURNALIST: A ninth adjustment, Mr. Tesla?
TESLA: Do everything that any day, any moment, if possible, not to forget who we are and why we are on Earth. Extraordinary people who are struggling with illness, privation, or the society which hurts them with its stupidity, misunderstanding, persecution and other problems which the country is full of a swamps with insects, leaves behind unclaimed until the end of the work. There are many fallen angels on Earth.

JOURNALIST: What is the tenth adaptation?
TESLA: It is most important. Write that Mr. Tesla played. He played the whole of his life and enjoyed it.

JOURNALIST: Mr. Tesla! Whether it relates to your findings and your work? Is this a game?
TESLA: Yes, dear boy. I have so loved to play with electricity! I always cringe when I hear about the one also the Greek who stole fire. A terrible story about studding, and eagles peck at his liver. Did Zeus did not have enough lightning and thunder, and was damaged for one fervor? There is some misunderstanding … Lightning are the most beautiful toys that can be found. Do not forget that in your text stand out: Nikola Tesla was the first man who discovered lightning.

JOURNALIST: Mr. Tesla, you’re just talking about angels and their adaptation to the Earth.
TESLA: Am I? This is the same. You could write this: he dared to take upon himself the prerogatives of Indri, Zeus and Peron. Imagine one of these gods in a black evening suit, with the bowler hat and wearing white cotton gloves prepares lightning, fires and earthquakes to the New York City elite!

JOURNALIST: Readers love the humor of our paper. But you confuse me stating that your findings, which have immense benefits for the people, representing the game. Many will frown on it.
TESLA: Dear Mr. Smith, the trouble is that people are too serious. If they were not, they would be happier and much longer would have lived. Chinese proverb says that the seriousness reduces life. Visiting the inn Tai Pe guessed that he visits the Imperial Palace. But that the newspaper readers would not have frowned, let’s get back to things which they consider important.

JOURNALIST: They would love to hear what your philosophy is.
TESLA: Life is a rhythm that must be comprehended. I feel the rhythm and direct on it and pamper in it. It was very grateful and gave me the knowledge I have. Everything that lives is related to a deep and wonderful relationship: man and the stars, amoebas’ and the sun, the heart and the circulation of an infinite number of worlds. These ties are unbreakable, but they can be tame and to propitiate and begin to create new and different relationships in the world, and that does not violate the old. Knowledge comes from space; our vision is its most perfect set. We have two eyes: the earthly and spiritual. It is recommended that it become one eye. Universe is alive in all its manifestations, like a thinking animal. Stone is a thinking and sentient being, such as plant, beast and a man. A star that shines asked to look at, and if we are not a sizeable self-absorbed we would understand its language and message. His breathing, his eyes and ears of the man must comply with breathing, eyes and ears of the Universe.

JOURNALIST: As you say this, it seems to me like I hear Buddhist texts, words or Taoist Parazulzusa.
TESLA: That’s right! This means that there is general knowledge and truth that man has always possessed. In my feeling and experience, the Universe has only one substance and one supreme energy with an infinite number of manifestations of life. The best thing is that the discovery of a secret nature, reveals the other. One cannot hide, there are around us, but we are blind and deaf to them. If we emotionally tie ourselves to them, they come to us themselves. There are a lot of apples, but one Newton. He asked for just one apple that fell in front of him.

JOURNALIST: A question that might be set at the beginning of this conversation. What was Electricity for you, Dear Mr. Tesla?
TESLA: Everything is Electricity. First was the light, endless source from which points out material and distribute it in all forms that represent the Universe and the Earth with all its aspects of life. Black is the true face of Light, only we do not see this. It is remarkable grace to man and other creatures. One of its particles possesses light, thermal, nuclear, radiation, chemical, mechanical and an unidentified energy. It has the power to run the Earth with its orbit. It is true Archimedean lever.

JOURNALIST: Mr. Tesla, you’re too biased towards electricity.
TESLA: Electricity I am. Or, if you wish, I am the electricity in the human form. You are Electricity; too Mr. Smith, but you do not realize it.

JOURNALIST: Is it thus your ability to allow fails of electricity of one million volts trough your body?
TESLA: Imagine a gardener who is attacked by herbs. This would indeed be crazy. Man’s body and brain are made from a large amount energy; in me there is the majority of electricity. The energy that is different in everyone is what makes the human ”I” or ”soul”. For other creatures to their essence, “soul” of the plant is the “soul” of minerals and animals. Brain function and death is manifested in light. My eyes in youth were black, now blue, and as time goes on and strain the brain gets stronger, they are closer to white. White is the color of heaven. Through my window one morning, landed a white dove, which I fed. She wanted to bring me a word that she was dying. From her eyes the light jets were coming out. Never in the eyes of any creature had I not seen so much light, as in that pigeon.

JOURNALIST: Personnel in your lab speak about flashes of light, flames and lightning that occur if you are angry or into kind of risk.
TESLA: It is the psychic discharge or a warning to be alert. The light was always on my side. Do you know how I discovered the rotating magnetic field and induction motor, which made me became famous when I was twenty-six? One summer evening in Budapest, I watched with my friend Sigetijem sunset. Thousands of fire was turning around in thousands of flaming colors. I remembered Faust and recited his verses and then, as in a fog, I saw spinning magnetic field, and induction motor. I saw them in the sun!

JOURNALIST: Hotel service telling that at the time of lightning you isolate into the room and talk to yourselves.
TESLA: I talk with lightning and thunder.

JOURNALIST: With them? What language, Mr.Tesla?
TESLA: Mostly my native language. It has the words and sounds, especially in poetry, what is suitable for it.

JOURNALIST: Readers of our magazine would be very grateful if you would interpret that.
TESLA: The sound does not exist only in the thunder and lightning, but, in transformation into the brightness and color. A color can be heard. Language is of the words, which means that it is from the sounds and colors. Every thunder and lightning are different and have their names. I call some of them by the names of those who were close in my life, or by those whom I admire. In the sky brightness and thunder live my mother, sister, brother Daniel, a poet Jovan Jovanovic Zmaj and other persons of Serbian history. Names such AsIsaiah, Ezekiel, Leonardo, Beethoven, Goya, Faraday, Pushkin and all burning fires mark shoals and tangles of lightning and thunder, which does not stop all night bringing to the Earth precious rain and burning trees or villages. There is lightning and thunder, and they are the brightest and most powerful, that will not vanish. They are coming back and I recognize them among the thousands.

JOURNALIST: For you, science or poetry is the same?
TESLA: These are the two eyes of one person. William Blake was taught that the Universe was born from the imagination, that it maintains and it will exist as long as there is a last man on the Earth. With it was a wheel to which astronomers can collect the stars of all galaxies. It is the creative energy identical to the light energy.

JOURNALIST: Imagination is more real to you than life itself?
TESLA: It gives birth to the life. I have fed by my taught; I’ve learned to control emotions, dreams and visions. I have always cherished, as I nurtured my enthusiasm. All my long life I spent in ecstasy. That was the source of my happiness. It helped me during all these years to bear with work, which was enough for the five lives. The best is to work at night, because the stellar light, and close bond.

JOURNALIST: You said that I am, like every being, the Light. This flatter me, but I confess, I do not quite understand.
TESLA: Why would you need to understand, Mr. Smith? Suffice it to believe it. Everything is light. In one its ray is the fate of nations, each nation has its own ray in what great light source we see as the sun. And remember: no one who was there did not die. They transformed into the light, and as such exist still. The secret lies in the fact that the light particles restore their original state.

JOURNALIST: This is the resurrection!
TESLA: I prefer to call it: return to a previous energy. Christ and several others knew the secret. I am searching how to preserve human energy. It is forms of Light, sometimes straight like heavenly light. I have not looked for it for my own sake, but for the good of all. I believe that my discoveries make people’s lives easier and more bearable, and channel them to spirituality and morality.

JOURNALIST: Do you think that time can be abolished?
TESLA: Not quite, because the first feature of the energy is that it transforms. It is in perpetual transformation, as clouds of Taoists. But it is possible to leverage the fact that a man preserves consciousness after the earthly life. In every corner of the universe exist energy of life; one of them is immortality, whose origin is outside of man, waiting for him. The universe is spiritual; we are only half that way. The Universe is more moral than us, because we do not know his nature and how to harmonize our lives with it. I am not scientist, science is perhaps the most convenient way to find the answer to the question that always haunt me, and which my days and nights turned into fire.

JOURNALIST: What’s the matter?
TESLA: How are your eyes brightened! … What I wanted to know is: what happens to a falling star as the sun goes out? Stars fall like dust or seed in this or in other worlds, and the sun be scattered in our minds, in the lives of many  beings,  what will be reborn as a new light, or cosmic wind scattered in infinity. I understand that this is necessary included in the structure of the Universe. The thing is, though, is that one of these stars and one of these suns, even the smallest, preserves.

JOURNALIST: But, Mr. Tesla, you realize that this is necessary and is included in the constitution of the world!
TESLA: When a man becomes concuss; that his highest goal must be to run for a shooting star, and tries to capture it; shall understand that his life was given to him because of this and will be saved. Stars will eventually be capable to catch!

JOURNALIST: And what will happen then?
TESLA: The creator will laugh and say: ”It fall only that you chase her and grab her.”

JOURNALIST: Isn’t all of this contrary to the cosmic pain, which so often you mention in your writings? And what is it cosmic pain?
TESLA: No, because we are on Earth … It is an illness whose existence the vast majority of people are not aware of. Hence, many other illnesses, suffering, evil, misery, wars and everything else what makes human life an absurd and horrible condition. This disease cannot be completely cured, but awareness shall make it less complicated and hazardous. Whenever one of my close and dear people were hurt, I felt physical pain. This is because our bodies are made as of similar material, and our soul related with unbreakable strands. Incomprehensible sadness that overwhelmed us at times means that somewhere, on the other side on this planet, a child or generous man died. The entire Universe is in certain periods sick of itself, and of us. Disappearance of a star and the appearance of comets affect us more than we can imagine. Relationships among the creatures on the Earth are even stronger, because of our feelings and thoughts the flower will scent even more beautiful or will fall in silence. These truths we must learn in order to be healed. Remedy is in our hearts and evenly, in the heart of the animals that we call the Universe.

Hydrogen Peroxide — “Medical Miracle”

Hydrogen peroxide (H2O2) ranks up there as one of the best household remedies. Hydrogen peroxide is one of the few “miracle substances” still available to the general public; it is safe, readily available, and dirt cheap. And best of all, it works!


Did you know that you probably had your first sip of hydrogen peroxide shortly after you took your first breath? That’s right… mother’s milk (especially colostrum) contains extremely high concentrations of H2O2. In light of the fact that we know that one of the main functions of mother’s milk is to activate and stimulate the immune system in the infant, the fact that it contains abnormally large amounts of H2O2 makes sense.

As far back as the early nineteenth century, hydrogen peroxide was widely used in medicine. Many bacterial diseases (including syphilis) responded to H2O2 when no other treatment was effective. In the early twentieth century, H2O2 was used to treat several common diseases, such as whooping cough, cholera, typhoid fever, ulcers, tuberculosis, and asthma. However, as the pharmaceutical industry began to develop expensive, new drugs, hydrogen peroxide was increasingly ignored and finally discarded as a treatment.

H2O2 stimulates natural killer (NK) cells, which attack cancer cells as they attempt to spread throughout the body. In the body’s immune response, hydrogen peroxide is released by T-cells to destroy invading bacteria, viruses and fungi. Blood platelets release hydrogen peroxide on encountering particulates in blood. In the large intestine, acidophilus lactobacillus produces H2O2 which keeps the ubiquitous candida yeast from multiplying out of control. When candida spreads out of the intestine, it escapes the natural control system and can gain a foothold in the organs of the body, causing what is called chronic fatigue syndrome.

During flu season, if the kiddos feel like they’re getting sick, we lay them down on their side and put a few drops of hydrogen peroxide into their ear. After a few seconds, the liquid will bubble, indicating that it is killing the infection. After 5 or 10 minutes, we turn them over and repeat on the other ear. No one yet fully understands the complete workings of hydrogen peroxide, but we do know that it is loaded with oxygen.

We know that when H2O2 is taken into the body (orally or intravenously) the oxygen content of the blood and body tissues increases dramatically. Please remember that the hydrogen peroxide that is available at your local pharmacy (3% hydrogen peroxide) should NEVER be ingested orally, since it contains many stabilizers. The only grade recommended for internal use is 35% Food Grade Hydrogen Peroxide, which must be properly diluted down to 3% with water. I use hydrogen peroxide each night before bed as a rinse and also a natural teeth whitener.

Metoclopramide and Diphenhydramine Blunt Pregnancy Headaches

Intravenous metoclopramide plus diphenhydramine is a more effective way to reduce headaches in pregnant women than codeine and is worth the extra cost, new research shows.

Results from the study support the use of this regimen to “break the cycle of headache pain,” said Katherine Scolari Childress, MD, from Saint Louis University in Missouri.

And both agents “are safe and nonaddictive,” she toldMedscape Medical News.

Dr Scolari Childress presented the study results here at the American Congress of Obstetricians and Gynecologists Annual Clinical Meeting 2015, where it was named First Prize Paper.

Headaches affect 15% to 20% of pregnant women, but few researchers have explored treatments, said Dr Scolari Childress.

Previous studies have shown that some antiemetics, such as metoclopramide, often in combination with antihistamines, can soothe the acute headaches of nonpregnant patients in the emergency department.

Because metoclopramide and diphenhydramine are relatively inexpensive, widely available, and considered to be safe for pregnant women, some clinicians use these drugs to treat headaches, Dr Scolari Childress explained.


The researchers looked at the effectiveness of a combination treatment of metoclopramide and diphenhydramine in a previous randomized controlled trial (NCT02295280) and found it to be more effective than codeine in providing headache relief in pregnant women.

They reanalyzed the data for the current study to see if the combination is more or less expensive than codeine.

They studied normotensive women in their second or third trimester who experienced primary headache not relieved by oral acetaminophen 650 to 1000 mg.

The women were randomly assigned to one of two treatments. In the combination group, 23 women received metoclopramide 10 mg plus diphenhydramine 25 mg, administered intravenously. In the monotherapy group, 21 women received codeine 30 mg.

Demographic characteristics, parity, gravidity, and gestational age were similar in the combination and codeine groups, as were rates of obesity, hypertension, and tobacco use.

Outcomes were better with the metoclopramide plus diphenhydramine combination than with codeine monotherapy.

Table. Study Outcomes

Outcome Combination Group, % Codeine Group, % P Value
Full headache relief 65.2 28.6 <.05
Perceived relief with one dose 100.0 61.9 .01
Would use the medication again 95.7 37.1 <.01
Headache recurrence 42.9 57.1 .17
Adverse effects 43.5 37.5 .24


Time spent in triage and time to perceived headache relief were not significantly different between the two groups.

As expected, an intravenous catheter was required by more women in the combination group than in the codeine group (23 vs 7).

The average cost of therapy was higher for the combination than for codeine ($1.54 vs $0.84); however, the combination is worth the additional cost because of its greater effectiveness, said Dr Scolari Childress.

“We are considering future studies looking at a regimen of oral metoclopramide and diphenhydramine,” she reported. In addition, the team wants to assess the combination in patients with elevated blood pressure, “who were excluded from this study.”

“This is a very interesting study,” said Sharon Phelan, MD, from the University of New Mexico in Albuquerque.

“Many women come in with a headache,” Dr Phelan told Medscape Medical News. “It used to be very common that everyone would just give narcotics. They work, but there is increasing concern about prescription drug abuse.”

Dr Phelan said she is disappointed that the combination studied was administered intravenously because this increases the cost and might deter some patients.

In addition, it is difficult to account for the placebo effect in a study when one treatment is given intravenously and the other is given mostly orally. “Some people think if they get something IV, it must be more potent,” she pointed out.

In Probiotics, ‘Gluten-Free’ Often a Misnomer

People with celiac disease might unknowingly be consuming gluten in their probiotic, report medical chemists who found trace amounts of gluten in about half of products labeled gluten-free.

“Gluten-free labelling does not accurately reflect the gluten content of probiotics,” said Samantha Nazareth, MD, from Columbia University in New York City.

The existing treatment for celiac disease, which affects approximately 1% of the population, is the lifelong exclusion of gluten. However, because inadvertent gluten exposure is common, this can be a challenge, Dr Nazareth explained.

Although gluten-free diets have gained in popularity, even among people without celiac disease, her main concern is for patients with sensitivities because of damage in the small intestine, she told Medscape Medical News. “Gluten definitely causes harm to them.”

People with celiac disease “should be aware of the potential for contamination with gluten, regardless of what the label says,” Dr Nazareth said. “Patients must take caution. They don’t know what they are getting.”

The US Food and Drug Administration (FDA) regulates the gluten-free label. It can only be used on products that contain less than 20 ppm of gluten; do not contain wheat, rye, or barley; and do not have an ingredient derived from these grains.

The FDA does not regulate herbal products, although 24% of patients with celiac disease take dietary supplements, most commonly probiotics, according to a previous study Dr Nazareth was involved in (J Clin Gastroenterol. Published online September 8, 2014).

Many Gluten-Free Claims Are False

Because symptoms related to celiac disease are reported more often by patients who take supplements than by those who do not, “our current study aimed to measure for the presence of gluten in popular probiotics,” Dr Nazareth explained.
Her team evaluated 22 of the most popular brands of probiotics on the national market. For each sample, they digested the probiotic 30 mg with pepsin, trypsin, and chymotrypsin. The researchers then conducted liquid chromatography–mass spectrometry analysis and quantitated marker peptides that represented wheat, barley, and rye.

They found that more than half of the probiotics labeled gluten-free contained the protein composite, and some of these contained more than 20 ppm, which exceeds the FDA threshold for the gluten-free labeling of food, Dr Nazareth pointed out.

Table. Analysis of Products Labeled Gluten-Free (n = 15)

Gluten Content Percent
Contained the protein composite 53
Contained more than 20 ppm 13.


Seven of the 22 probiotics, or 31%, were not labeled gluten-free. Of these, four tested positive for gluten, and two contained more than 20 ppm.

Twelve of the 22 probiotics, or 55%, actually contained some measure of gluten. Of these, eight, or 67%, were labeled gluten-free.

More than one gluten component — wheat, rye, or barley — was detectable in four of the 22 probiotics, and two of these products were labeled gluten-free.
It is not known how much gluten is safe for patients with celiac disease. Trace amounts are probably not enough to induce villous atrophy, Dr Nazareth acknowledged, but it is possible that any amount could aggravate symptoms. The biggest concern is that two of the 22 products exceeded the FDA threshold.

“The amount of gluten in probiotics may be significant, especially if one considers the cumulative number of capsules consumed,” she pointed out.

Dr Nazareth advised physicians to ask patients about probiotic use and to consider the possibility of contamination with gluten.

It’s still a bit of the Wild West out there.
Are people with celiac disease deriving enough benefit to accept the risk of inadvertent gluten contamination? The benefit of probiotics has not been firmly established in terms of improving markers of disease, although patients have reported improvements in some symptoms, Dr Nazareth explained.

The potential contamination of probiotics with gluten is “a huge issue,” said Jenifer Lightdale, MD, from the University of Massachusetts Medical School in Worcester.

She praised the researchers for “starting to get at the fact that people with celiac disease need to be safe and to really question everything they are taking.”

“There’s been a movement toward feeling comfortable about probiotics, which is great, but maybe not for patients with celiac disease,” she told Medscape Medical News.

Dr Lightdale added that inadvertent exposure in children with celiac disease might affect growth, without warning. “Some kids don’t realize they don’t feel well, and it may take a while to realize they are being exposed to gluten,” she explained.

“We clearly need to regulate gluten-free products, including supplements. In fact, this study speaks to the need to regulate probiotics in general. It’s still a bit of the Wild West out there,” she said.

“People are interested in gluten-free diets and in probiotics. These two movements are merging, and we need to make sure that probiotics are clear on whether they contain gluten,” Dr Lightdale said.

New Drug Class in the Works for Ulcerative Colitis

Ozanimod, a novel sphingosine 1-phosphate receptor modulator, is safe and effective in the treatment of patients with moderate to severe ulcerative colitis, according to results from the phase 2 TOUCHSTONE study.

“Ozanimod 1 mg induced clinical remission at week 8, the primary end point, and met all three secondary end points,” said William Sandborn, MD, from the University of California, San Diego.

“And the favorable benefit–risk profile supports the planned phase 3 trial and the phase 2 study in Crohn’s disease,” he reported here at Digestive Disease Week 2015.
The drug, an oral S1P receptor of subtypes 1 and 5, is also being evaluated in relapsing multiple sclerosis, Dr Sandborn explained. However, ozanimod has a more favorable safety profile than the SP1 receptor modulator fingolimod, which has been used on more than 100,000 multiple sclerosis patients.

The international 8-week induction trial involved 197 patients with moderate to severe ulcerative colitis, defined as a Mayo score of 6 to 12 and an endoscopy subscore of at least 2. For responders, there was a continuing maintenance period.

Patients were randomized to ozanimod 0.5 mg, ozanimod 1.0 mg, or placebo.

The primary end point was remission at week 8, defined as a Mayo score of 2 or lower and no subscore greater than 1.

The secondary end point of response was defined as a reduction in Mayo score of at least 3 and at least 30%, and a decrease in the rectal bleeding score of at least 1 or a rectal bleeding score of 1 or lower. The other secondary end points were mucosal improvement, defined as an endoscopy subscore of 1 or lower, and change in Mayo score.

The induction portion of the study was completed by 95% of patients.

“A dose–response relationship was observed for all primary and key secondary efficacy end points,” Dr Sandborn reported.

The differences between high-dose ozanimod and placebo were significant for clinical response (P = .0207), clinical remission (P = .0482), mucosal improvement (P = .0023), and improvement in Mayo score (P = .0035).

The differences between low-dose ozanimod and placebo were significant for mucosal improvement (P = .0348).

Table 1. TOUCHSTONE Study Outcomes

Outcome Ozanimod 1.0 mg Ozanimod 0.5 mg Placebo
Clinical remission at week 8, % 16.4 13.8 6.2
Clinical response at week 8, % 56.7 53.8 36.9
Mucosal improvement at week 8, % 34.3 27.7 12.3
Improvement in Mayo Score from baseline, points 3.3 2.6 1.9

Safety assessments included electrocardiogram, Holter monitoring, pulmonary function testing, optical coherence tomography, and adverse events.

Adverse event profiles were comparable in the three groups, with approximately 31% of patients experiencing a treatment-emergent adverse event in each group.

Table 2. Adverse Events

Adverse Event Ozanimod 1.0 mg, % Ozanimod 0.5 mg, % Placebo, %
Worsening of ulcerative colitis 1.5 3.1 4.6
Anemia or decreased hemoglobin level 0.0 4.6 6.2
Serious treatment-emergent event 1.5 1.5 6.2

Three patients receiving ozanimod experienced transient elevations in alanine aminotransferase. There were no significant cardiac, ophthalmologic, or infectious findings.
During a plenary lecture, Maria Abreu, MD, from the University of Miami Health System, expressed optimism about the use of SP1 receptor modulators in ulcerative colitis.

SP1 receptor modulators sequester T-cells, “so they can’t get out of the gut,” she explained. “Ozanimod basically interferes with the ability of the cells to recognize their way back out of the lymph node.”

“Presumably this is a new and improved version of molecules that have been used effectively in multiple sclerosis,” she added.

“This is a new class of drug that might work differently from current drugs for inflammatory bowel disease,” said Charles Bernstein, MD, from the University of Manitoba in Winnipeg, Canada.

“They’ve been successful in multiple sclerosis, and both IBD and MS are T-cell-mediated diseases,” he told Medscape Medical News. “There’s a lot of enthusiasm, therefore, that this may be a class of drug that will be very beneficial. Also, the safety data in TOUCHSTONE look very good.

“We are looking forward to seeing more about this drug,” he said.

EMA Committee Warns of Small Cardiovascular Risk With High-Dose Ibuprofen

The Pharmacovigilance Risk Assessment Committee (PRAC) of the European Medicines Agency (EMA) is warning of an increased risk of cardiovascular events in patients who take high doses of the anti-inflammatory ibuprofen[1].

The committee, which began its review in 2014, states there is a small increase in the risk of MI and stroke with ibuprofen when taken at doses of 2400 mg/day or higher. The risk, according to the committee, is similar to the risk observed with other nonsteroidal anti-inflammatory drugs (NSAIDs), such as COX-2 inhibitors and diclofenac.
In 2013, as reported by heartwire , researchers published data showing diclofenac, a drug used for pain and inflammation, increased the risk of cardiovascular events between 38% and 63% in different studies. The EMA reached similar conclusions in 2012, concluding there was a consistent but small increase in the risk of cardiovascular side effects with diclofenac compared with other NSAIDs.

The committee is recommending physicians assess patients’ risk factors for cardiovascular conditions before starting them on long-term high-dose ibuprofen. Overall, PRAC says the benefits of high-dose ibuprofen outweigh the small increased risk of cardiovascular events, but physicians should use caution when prescribing and avoid high-dose ibuprofen in select patients.

“High doses of ibuprofen (2400 mg per day or higher) should be avoided in patients with serious underlying heart or circulatory conditions, such as heart failure, heart disease, and circulatory problems or in those who have previously had a heart attack or stroke,” according to PRAC.

With 1200 mg of ibuprofen, the most commonly used over-the-counter dose of ibuprofen in the European Union, there is no signal of harm, according to PRAC. The recommendations of the committee also extend to dexibuprofen, which is similar to ibuprofen. A high-dose of dexibuprofen is 1200 mg/day or more.

The recommendations of PRAC will now be sent to the Coordination Group for Mutual Recognition for Decentralized Procedures—Human (CMDh). The CMDh reviews the recommendations of PRAC and will adopt a final position.

Panel Recommends Steps for Safer Epidural Injections

The risk for rare but potentially catastrophic neurological injuries from epidural steroid injections (ESIs) can be substantially reduced if anesthesiologists and other clinicians follow specific safety measures, according to members of a consensus panel representing 13 national medical organizations.

“We acknowledge that catastrophic neurologic injuries can and do occur during epidural steroid injections. The actual incidence is unknown, but epidural steroid injections are common and reports of these neurologic injuries are uncommon. The purpose of this multidisciplinary effort was to review the available evidence and assemble the best clinical considerations for reducing or eliminating these injuries,” the panelists write in an article published online February 9 in Anesthesiology.
Panel members represent a wide range of specialists, including anesthesiologists, pain medicine specialists, orthopedic surgeons, interventional radiologists, and physical medicine and rehabilitation specialists. Panel meetings were facilitated by the US Food and Drug Administration’s Safe Use Initiativesocieties.

17 Items

The panelists arrived at 17 specific recommendations, 10 of which all 13 organizations agreed to.

For example, all groups agreed on the following:

practitioners must wear face masks and sterile gloves during the procedure,

all cervical and lumber interlaminar injections should be performed under image guidance,

cervical interlaminar ESIs are recommended at vertebrae C7 to T1, but preferably not higher than the C6 to C7 level,

no cervical interlaminar ESIs should be performed at any segmental level without ensuring via imaging studies that there is adequate epidural space for placement of the needle, and

the treating physician should make the ultimate choice of an interlaminar or transforaminal technique and should be made by weighing potential risks and benefits with each technique for a given patient.

Other recommendations received a majority of agreement from no fewer than 11 of the 13 organizations. For example, two groups were unable to reach consensus on whether a non-particulate such as dexamethasone should be used in initial lumbar transforaminal injections, and two could not decide whether cervical and lumbar interlaminar ESI can be performed without contrast in patients with contrast allergy or anaphylactic reactions.

On the whole, however, the recommendations reflect a strong majority opinion about optimal clinical practices.

A Good Start, But…

In an accompanying editorial, Brian Thomas Bateman, MD, MSc, and Gary J. Brenner, MD, PhD, from the Department of Anesthesia, Critical Care, and Pain Medicine at Massachusetts General Hospital in Boston, call for research into the causes and prevention of injuries associated with well-intentioned ESIs.
“While the Working Group’s consensus statement is an important step forward for pain medicine, it is essential that as a field we perform the studies that will better elucidate the risks of [ESI], to further refine the Group’s suggestions,” they write.

They note that “[t]he annual number of epidural injections performed on Medicare beneficiaries has approximately doubled since 2000; in 2012 alone there were over 2 million claims submitted to Medicare for ESIs.” However, the true incidence of the catastrophic complications is unknown because prospective studies have not been done.

The editorialists call for better understanding of factors that may contribute to risk for serious neurological injuries from ESI, such as patient-specific, technical, and pharmacologic factors.

“We need to also understand the effect on risk of the background and training of the clinicians performing the procedure, particularly as many practitioners performing ESIs have not completed a formal pain fellowship,” they write.

Sacral Stimulation Aids Bowel Function After Spinal Injury

Sacral anterior root stimulation (SARS) appears to help bowel emptying in patients with spinal cord injury (SCI), according Danish and German researchers.

“SARS seems to have the potential to be one of the few treatment methods targeting multiple organ dysfunctions following SCI, Dr. Mikkel Mylius Rasmussen, of Aarhus University Hospital in Denmark, told Reuters Health by email. The findings would benefit from validation through prospective-designed studies with validated objective endpoints encompassing bladder and bowel dysfunction.”

“However,” he added, “we find the conclusions from this study encouraging and believe it to support a more widespread use of SARS targeting both bladder and bowel dysfunction among SCI subjects.”

Few studies have focused on the effects of SARS on bowel function, probably because the stimulator was developed for bladder management.
In a January 20 online paper in Spinal Cord, Dr. Rasmussen and colleagues write that to investigate, they surveyed and interviewed subjects who had undergone surgery for SARS and sacral deafferentation. Their median age was 49 years and median time to surgery after SCI was 10 years.

Of 333 patients, 67% used SARS routinely for bowel emptying. Supplementary use in a further 19 brought the proportion to 73%.

Analysis of outcomes in the 277 who continued to use SARS showed that the median visual analogue score (VAS) for overall satisfaction with treatment was 10 (range: 0-10). Baseline and follow-up comparison of bowel symptoms showed a highly significant decline in the median VAS score on a 10-point scale from 6 to 4. Similarly, median neurogenic bowel dysfunction score fell from 17 to 11.

Interestingly, say the investigators, “the effect of SARS does not seem to decrease with time as the neurogenic bowel dysfunction score was not associated with time since the surgery.”

Moreover, they add, “Changes in the neurogenic bowel dysfunction score were supported by an improved continence and reduced constipation when evaluated by the St Marks fecal incontinence score and the Cleveland constipation score.”
In addition, “the frequency of defecation increased, time consumption for defecation decreased, as did unpleasantness during defecation. This was in accordance with significantly reduced use of laxatives, suppositories, digital evacuation and mini enemas.

The researchers conclude, “Although initially invented for bladder management, our results support a simultaneous positive effect on neurogenic bowel dysfunction.”

Genomic Entrepreneurs Promise to Personalize Medicine

The era of personalized medicine continues to advance with the introduction of products that can analyze genes, developers report.

“Eventually, everyone will have their genome sequenced,” said Reid Robison, MD, MBA, from Tute Genomics. “Imagine a world in which your medical care is 100% unique. Every diagnosis, every medication, every dietary guideline can be tailored to you and only you.”

Dr. Robison and other genomics experts presented their ideas here at Health 2.0 Annual Fall Conference.

Tute Genomics uses machine-learning algorithms to analyze an individual’s genome for susceptibility to genetic disorders and adverse drug reactions. Tute is making its findings available to patients, clinicians, and researchers.
BaseHealth goes a step further, said Jorge Velarde Jr., MBA, who is chief executive officer and president of the company. Genomics information from partner companies is combined with lab results, family history, nutrition information from questionnaires, and other data. “Not only do we collect it once, but we are constantly collecting,” he said.

The company produces charts and graphs to show patients how they can alter their risk for conditions like type 2 diabetes. For example, it might compare the benefits of lowering triglycerides with the benefits of lowering blood pressure.

“We rank your risks so you can actually focus on what is important to you,” he said.

Some patients might need more than a chart to help them interpret the significance of their genomes.

Imagine a world in which your medical care is 100% unique.
To fill that gap, Counsyl provides educational videos related to the findings. People who have questions can contact a human genetic counselor through the program’s interface, explained Laura Martini, director of product design, who represented the company during the session.
The future of personalized medicine “is not just the raw data, it’s having access to healthcare professionals who can help make sense of it and discuss next steps,” said Martini.

Helping genomics researchers get paid for their work is the aim of YouGene, said technical officer Ryan Downs. Each time a clinician prescribes a test that uses a patented biomarker, YouGene collects a royalty and disburses it to the patent holder.

The program benefits clinicians by giving them access to the newest tests, benefits researchers by paying them for their work, benefits insurers by lowering the cost of healthcare, and benefits patients by encouraging more research, Downs explained.

“What we provide is the liquidity between all these stakeholders,” he said. “It helps grease the wheels of innovation.”

During the discussion period after the session, an audience member asked whether the companies are legally liable for their interpretation of a patient’s data. “If I want to take a test, do I have to sign your disclaimer,” he asked. “Can people sue you?”

Martini explained that users do have to sign waivers. “That’s very standard with every sort of lab test. We don’t use the data for anything beyond clinical use and research,” she noted.

Velarde reported that the program at BaseHealth complies with the Health Insurance Portability and Accountability Act of 1996 and the Clinical Laboratory Improvement Amendments of 1988. “The information is delivered by a physician,” he said.

MSSA Bloodstream Infection: Beta-Lactams or Vancomycin?

Beta-lactams are superior to vancomycin for definitive therapy, but not empiric treatment of methicillin-susceptible Staphylococcus aureus (MSSA) bloodstream infection, according to a large retrospective study.

Jennifer S. McDanel, PhD, from the University of Iowa in Iowa City and the Iowa City Veterans Affairs Health Care System, and colleagues published their findings online April 21 in Clinical Infectious Diseases.

Although prior research has linked vancomycin therapy to poor patient outcomes such as recurrence, treatment failure, and death, the validity of this construct with respect to empiric therapy has remained unclear.

“Vancomycin is often prescribed empirically for patients suspected of having S. aureus bloodstream infections since it has activity against both methicillin-resistant and methicillin susceptible strains,” the authors write.
“However, for a patient infected with [MSSA], organizations such as the Infectious Diseases Society of America…recommend switching therapy to a beta-lactam, such as cefazolin or an antistaphylococcal penicillin (nafcillin or oxacillin) once the isolate is known to be MSSA.”

Accordingly, the researchers analyzed data for MSSA culture-positive patients at 122 Veterans Affairs hospitals who received either a beta-lactam or vancomycin alone as empiric therapy (n = 2659 and 3125, respectively) or definitive treatment (n = 4698 and 935, respectively) during 2003 to 2010.

The researchers defined empiric therapy as treatment started 2 days before through 4 days after collection of the first culture positive for MSSA; definitive therapy started 4 to 14 days after collection of the first culture positive for MSSA.

Empiric use of beta-lactam monotherapy had no effect on 30-day mortality compared with vancomycin (hazard ratio [HR], 1.03; 95% confidence interval [CI], 0.89 – 1.20).

As expected, however, definitive therapy with a beta-lactam rather than vancomycin was associated with a significant 35% decrease in 30-day mortality (HR, 0.65; 95% CI, 0.52 – 0.80), with use of cefazolin or an antistaphylococcal penicillin yielding further benefit (HR, 0.57; 95% CI, 0.46 – 0.71).
Although the researchers made adjustments for variables such as age, dialysis/end-stage renal disease, Acute Physiology and Chronic Health Evaluation (APACHE) III score, and Charlson Comorbidity index, the authors note that the findings may be limited by the elderly nature of the study population, and some of the reported deaths may not have been attributable to MSSA. In addition, the researchers did not stratify the definitive therapy analysis by empiric therapy, and therefore did not account for potential switching-related survival benefits.