Scientists find possible cause of asthma, and how to prevent an attack .


For the first time, researchers in the UK have discovered that a particular protein is playing a key role in the development of asthma, and knowing this, they’ve found a class of drugs that can effectively treat its most harrowing symptoms.

Working with mouse models and human airway tissue from asthmatic and non-asthmatic volunteers, the team found that an existing class of drugs, called calcilytics, can be surprisingly effective in reversing some of the worst symptoms of the condition, including the narrowing of the airways, which causes a shortness of breath; and airway twitchiness and inflammation.

The research is pretty encouraging, because while some people respond well to available treatments, one in 12 people affected by asthma are yet to find a medication that works for them. Working with these drugs could mean a more comprehensive treatment option for asthmatics. The team also thinks it could work as a treatment for other illnesses that are associated with throat inflammation, such as chronic obstructive pulmonary disease (COPD) and chronic bronchitis.

Interestingly, calcilytics were first developed around 15 years ago as a treatment for osteoporosis, because they showed potential in strengthening deteriorating bones by triggering a release of hormone via a type of protein called a calcium sensing receptor (CaSR). While they proved disappointing and ultimately ineffective in treating osteoporosis, they were at least found to be safe for people and caused minimal side effects, which is why they’re such a promising option for future asthma trials.

“Our findings are incredibly exciting,” lead researcher Daniela Riccardi, from the Cardiff University School of Biosciences, said in a press release. “For the first time we have found a link between airways inflammation, which can be caused by environmental triggers – such as allergens, cigarette smoke and car fumes – and airways twitchiness in allergic asthma.”

Publishing in the journal Science Translational Medicine, Riccardi and her team discovered that CaSR is activated by these environmental triggers, but the when calcilytics drugs are nebulised directly into the lungs, they deactivate CaSR and prevent every one of the main symptoms of asthma from occurring.

Samantha Walker, Director of Research and Policy at Asthma UK, discusses the findings in the press release:

“This hugely exciting discovery enables us, for the first time, to tackle the underlying causes of asthma symptom. If this research proves successful, we may be just a few years away from a new treatment for asthma, and we urgently need further investment to take it further through clinical trials. 

Asthma research is chronically underfunded; there have only been a handful of new treatments developed in the last 50 years so the importance of investment in research like this is absolutely essential.”

The team is now looking at getting the funding they need to get calcilytics into clinical trials once they can prove that direct application to the lungs is safe. They predict that the treatment could be available in as little as five years time. “If we can prove that calcilytics are safe when administered directly to the lung in people, then in five years we could be in a position to treat patients and potentially stop asthma from happening in the first place,” said Riccardi.

‘Running can cause virginity loss’: Aussie Islamic school refutes allegations of odd claim .


An Islamic college in Australia is denying allegations its principal forbade female students from running in a cross-country race because he was convinced they would “lose their virginity.”

 

Reuters / Atef Hassan

The claims come from a former teacher who wrote to Victorian state Education Minister James Merlino alleging that Omar Hallak, the principal at the Al-Taqwa school, believed girls could lose their virginity by running excessively.

Merlino told reporters on Thursday the Victorian Registration and Qualifications Authority was investigating the allegations.

The school issued a statement on Thursday to refute the claims.

“Contrary to reports in the media, female students at Al-Taqwa college participate in all range of sporting activities such as track and field (including running over a range of distances, long jump, high jump, shot put, discus, athletics), basketball, cricket, hockey, tennis and netball,” it read, according to the Guardian.

It goes on to say that, aside from a lack of parental consent, nothing could stop the girls from participating.

“We do not believe that running excessively may cause female students to lose their virginity or that sporting injuries could render them infertile,” the statement went on, dispelling any doubts about the school’s knowledge of elementary biology.

Top 12 Free iPhone Medical Apps For Doctors And Medical Students


1. Medscape Medscape again tops the list as the number one free medical app for medical professionals. The amount of free content provided by Medscape is absolutely mind boggling and seems to continuously grow with each update. 7,000+ drug references, 3,500+ disease clinical references, 2,500+ clinical images and procedure videos, robust drug interaction tool checker, CME activities, and more. Many use Medscape as a simple drug reference tool, but its true value is in the disease and condition clinical references it provides.The Medscape app is actually a mini-textbook packed with protocols for disease pathologies. It’s not as detailed as the famous Pocket Medicine Red Book — but it does more than an adequate job of providing clinical pearls from the most common to less common pathologies.

2. Micromedex This might come as a surprise to many, but after you use this prescription medical reference app you’ll understand why it ranks so high. The overall user interface of the app is simple and quick. There is minimal clutter — another reason for such a high ranking. If you need to look up a dose or some quick reference information about a drug you can accomplish this with ease, as shown in the below pictures. There are no prompts to register your e-mail address, no CME activities, no icon badges, no notifications, or any other distractions. The one knock on this app is it doesn’t have a robust drug interaction checker, something Medscape and Epocrates provide. On the flip side, for residents and medical students, the app does a better job than other drug reference apps when it comes to mechanism of action information and patient teaching information. Another plus is it’s available for the iPad — which is not true of Epocrates and Medscape.

3. New England Journal of Medicine The NEJM app is clearly a must have for all health care professionals. The caveat is that when this app was released the NEJM stated it would be free for a “limited time” in the iTunes description — that was more than 5 months ago and the app still remains free, allowing you to access fantastic NEJM content customized for the mobile format. The app allows you to access the last 7 days worth of published articles, along with images of various medical conditions and videos on how to perform procedures such as LPs and chest tubes. Where this app is essential though is with the weekly audio summaries and the selection of four full text audio reads of clinical practice articles. Note, you can access the weekly audio summaries via podcast format as well. This type of content access in mobile form is great for keeping abreast of changing clinical practices while driving back and forth to work or when having downtime in the wards.

4. Epocrates: There is no denying Epocrates is one of the best medical reference tools in the mobile format. The free version of Epocrates, Epocrates Rx, provides great content: Drug monographs and health plan formularies, drug interaction tool, pill identifier, medical Calculator, and a new addition: Medical News and handpicked clinical articles.

5. Free Medical Calculators This post used to consist of a popular medical app that was at one time free, MedCalc, but we did a feature article on free medical calculators, and there are a great deal of choices. One of our favorite free medical calculators is Calculate (Medical Calculator) by QxMD.

6. Radiology 2.0: One night in the ED This rich case learning radiology tool is based on content organized by Dr. Daniel Cornfeld, an Assistant Professor of Diagnostic Radiology at Yale University School of Medicine who specializes in Body and Emergency Medicine Imaging. The app was inspired by Dr. Cornfeld’s website, One night in the ED. The app does a fantastic job of giving case based presentations of radiology imaging, and as our writer Dr. Amit Patel pointed out in his review, it’s an application non-emergency medicine residents can find very useful. Another plus of the app is it’s on the iPad as well.

7. Skyscape: RxDrugs and OCM (Outlines in Clinical Medicine) Skyscape has a lot of potential, and it’s done a great job of flooding the mobile market place with medical apps that are useful. The free offerings from Skyscape are in the form of RxDrugs and OCM. RxDrugs is basically a drug reference tool, while OCM (outlines of Clinical Medicine) is somewhat like the disease pathology information offered by Medscape, except in a more difficult format to use. And there inlies the issue with these Skyscape apps — great content, but overall user interface experience is lacking. The apps don’t flow as well as the other drug and clinical disease reference apps mentioned prior.

8. Living Medical Textbooks Living Medical Textbooks by Projects in Knowledge is an application that for some reason has gotten little to no hype in the App Store. There are actually 5 Living Medical Textbooks, ranging in topics from Diabetes to Multiple Sclerosis. The apps offer CME activities, but what makes them particularly appealing is they are “dynamic” — meaning the chapters are updated when noteworthy new medical data or research is introduced in medicine. So basically, if you download the “Diabetes” textbook app, you can be assured that you are being kept abreast of new medical knowledge and clinical studies regarding Diabetes — the app updates and adds chapters periodically. For those not even concerned with doing CME activities this textbook app is a great resource for clinical knowledge. Along with updated clinical content, the apps contain basic knowledge of the disease pathologies they are based on.

9. Medical Radio We’ve been a fan of ReachMD’s Medical Radio for as long as we can remember. ReachMD has an XM Satellite Radio broadcast (XM 160) station that allows medical professionals to do CME activities. Their application is great because it allows you to not only listen to the live feeds, but to listen to pertinent content by your specialty. In the example given in below pictures, Emergency Medicine specific content pulls up interesting conversations and also discussions on recent literature. Even if you’re not interested in CME activities, it’s a great way to keep up to date on new literature.

10. Neuromind Neuromind is a production of Pieter Kubben, a Dutch neurosurgeon who is an impressive amalgam of clinician, researcher, and software engineer. His application is a simple reference tool for neurologists, neurosurgeons, and other clinicians who need reference material for neuro based pathologies.

11. Prognosis: Your Diagnosis Prognosis: Your Diagnosis is an app from Medical Joyworks — produced out of Sri Lanka, where one of the goals of the developers of the app was to “make medicine fun”. Some of the developers themselves are medical professionals. The app is marketed as a clinical case simulation game for physicians, medical students, nurses, and paramedics. The app has been one of the most downloaded free medical apps recently released. We found the simulation cases fun to go through, however, the level of clinical content is more suited for medical students and paramedics, and is not advanced enough for residents and those in higher training. The developers of the application are promising more future cases, and we can only assume the degree of complexity will increase in the future. In the attached pictures we go through a simulation for the chief complaint ”“ “Jaw Pain”. Our full review contains the whole simulation.

12. Harvard’s Public Health News App The Harvard School of Public Health News app is surprisingly functional and useful. We say surprisingly because Harvard isn’t the first school to make an application to push their content, but they stand out amongst their peers for the simplicity, overall user interface, and solid functionality delivered by the application. The app features news articles from the School of Public Health — however, the articles link to the school website, and it would be nice if they were native or customized for the app. But the true functionality comes from the delivery of audio and video content. Some of the best minds in Public Health are at Harvard and the multimedia content is rich with useful knowledge.

Never Pay Another Power Bill Again: Quantum Energy Generator.


The QEG, is a power source based off of Tesla’s Public Domain Design. The QEG is portable, about the size of your average home generator, can easily be hooked up to your existing home electrical system, and weighs around 120 pounds. It can power your entire home, and you would never need to pay another power bill again!

“The QEG belongs to humanity now. Many will make further improvements and we will all co-develop this practical bridge technology together.” HopeGirl

The QEG is scaled to produce power in the range of 10-15 kilowatts continuously, and can be wired to produce eithe 120 Volt or up to 240 Volt single phase output.

A community in Morocco built the working device in only 3 days. The video below shows them turning on the device for the first time, so there is no telling what tweaks will be made in the days following to increase the power output.

Watch the video. URL: https://youtu.be/r0q-C3fDiw8

Gene therapy using HIV-derived vector has cured rare condition.


A small study using an experimental gene therapy to correct defects in DNA has transformed the lives of six boys with a deadly immune disorder, researchers report.

Wiskott-Aldrich syndrome is a rare genetic disorder that affects up to 10 children in every million born, and occurs almost exclusively in males.

The syndrome is characterised by eczema, low platelet counts in the blood, which results in bruising, and a compromised immune system that leaves people vulnerable to a suite of recurring and potentially deadly infections such as pneumonia. People with the condition can also suffer severe nose bleeds and bloody diarrhea.

In the two years since the treatment was administered, there has been a significant decrease in the number of infectious complications that often arise with the illness, and the average number of days spent in hospital for the study participants has dropped from 25 per year in the two years before the treatment to zero days in the two years following.

“This study demonstrated the feasibility of the use of gene therapy in patients with Wiskott-Aldrich syndrome,” the researchers noted.

The findings, which were published in the Journal of the American Medical Association, could revitalise interest in gene therapy, which involves functional genes being inserted into cells to correct defects and help reverse genetic diseases.

But the researchers also caution that, “controlled trials with larger numbers of patients are necessary to assess long-term outcomes and safety.”

As James Gallagher from the BBC explains, the syndrome “stems from an error in the genetic code that contains the building instructions for a key element in the immune system – a protein called WAS.”

Current treatment options involve bone marrow transplants, whereby hematopoietic stem cells from a donor can help restore some level of immune function.

But these transplants are only viable when there’s a prospective donor with a close tissue match, and even then, researchers say there’s usually a high rate of complications involved.

So researchers in the UK and France have begun investigating a gene therapy option, which they say could be more effective and safer.

With this technique, researchers use stem cells from the sick individual rather than from a donor. These cells are extracted and modified – or infected, rather – with an advanced lentiviral vector, which is derived from HIV.

These vectors have become an important tool for gene delivery to cells, and arepromising for gene therapy because they can infect both dividing and non-dividing cells, and can change the expression of their target cell’s gene for long periods of time.

In a trial that took place at the Great Ormond Street Hospital in the UK and Necker Children’s Hospital in France, researchers administered this gene therapy to seven male patients with severe Wiskott-Aldrich syndrome between 2010 and 2014. These patients ranged in age from about eight months to 16-years-old.

While one of the seven patients passed away from a pre-existing infection, the results for the surviving patients seem encouraging.

In the 24 months following treatment, researchers reported that infectious complications related to the illness were resolved in all six patients, with three of them able to stop taking preventative antibiotics.

Furthermore, severe eczema was cured in all affected patients, as were signs and symptoms of autoimmunity.

Patients have also recorded no severe bleeding episodes after treatment, and have seen a remarkable decline in hospital visits.

“I think it is very significant, it is another clear and powerful demonstration that a gene therapy approach is an effective one.” study co-author and immunologist, Adrian Thrasher, from Great Ormond Street Hospital, told the BBC.

“What we hope, and the evidence is certainly suggestive of this, is that the therapeutic effect will last for a very substantial amount of time, such that the patients should not need another treatment and so therefore we hope that it will be lifelong.”

Robo chef: Would you trust a cook with no taste buds?


“Never trust a skinny chef,” goes the old saying. But what about one without taste buds?
It might not be able to sample its own handy work, but this robot chef can whip up an apparently “delicious” crab bisque in just 30 minutes — the first of an expected repertoire of 2,000 recipes.

Much like an “iTunes of food,” consumers will be able to select dishes from the mechanical cook’s vast digital library, all served up in their very own kitchen.
Though judging by this prototype, they’ll have to make sure each ingredient, spoon, and pan is perfectly placed first.
Modeled on the movements of Britain’s 2011 Master Chef winner Tim Anderson, the robot is programmed to reach, stir, and pour, in exactly the same way as its human teacher, right down to the precise tilt of an olive oil bottle.
“The current model is purely based on rote movements, so if anything is out of place it won’t work,” said Anderson, who worked with British company Moley Robotics to create the machine, due to go on sale in 2017 with an estimated price tag of $15,000.
“One of the biggest challenges is that ingredients are so inconsistent — they come in different shapes and sizes, and are in different places all over the kitchen,” said Anderson. “So that’ll be the next stage of development.”
The ultimate sous chef?
Indeed, rummaging in a cupboard or darting across the kitchen, are currently beyond the realms of the giant mechanical arms which hover above a specially designed hob.

The Robot Chef went on show at manufacturing trade fair, Hannover Messe, in Germany last week.
But the robot’s lack of spontaneity — what cook hasn’t added a little extra salt here or there? — is also what makes it the “ultimate sous chef,” according to Anderson.
“It’s so consistent, it always makes the exact same bowl of food. And that’s the mark of a really great chef,” he said.
“You know it won’t try and improvise or use an intuition — because it has none.”
That said, no two ingredients are necessarily the same, and engineers are now developing extra sensors for such delicate tasks as beating egg whites into perfectly stiff peaks.
“Things such as whisking egg whites into a meringue is very visual, because every egg is a little bit different,” explained Anderson.
“But a robot will still be able to tell when it’s reached a certain consistency, by feedback from the pressure and friction in the egg whites as they’re whipped.”
Handy kitchen appliance
So what kind of person would actually own a robot chef? The kind that are too tired, too strapped for time, or just too apathetic to cook, says Anderson.
“It could also be an advantage for disabled people who want freshly cooked food but don’t have a carer,” he added.
And then there’s the people who might just want to show off their futuristic new kitchen appliance.
robot chef pic 1
Thousands of recipes could just be a click away, with the Robot Chef app.
“The early adopters are going to be people saying ‘hey, come to my house, I’ve got this amazing robot chef, you should see what it does, you should taste the bisque,'” said Anderson. “Everyone loves a bit of theater with their food.”

 

robot chef app
Loveless cooking?
The high-tech machine might be able to mimic a Master Chef — but can it ever really cook with love and care?
“Cooking with love is down to the effort that goes into it,” said Anderson. “If somebody makes you a lasagne then you know they love you because a lasagne is a lot of work!
“The robot could make food that would taste just like how a human would make it — but it can never really capture that sentiment.”
It seems there’s still some improvements to be made before Robot Chef hits the market in two years. Expressing love, might just be one of them.

Depression’s Physical Impact Extends To Mitochondrial DNA And Telomere Length


In some cases, scientists are able to trace the earliest beginnings of disease to adverse life experiences, particularly those occurring in childhood. A new study uncovers the metabolic signature of one form of illness that may occur in childhood: depression. Episodes of major depression, the researchers found, change the amount of mitochondrial DNA as well as the length of telomeres in sufferers.

Sometimes called the cell’s powerhouse, a mitochondrion is a membrane-bound structure within a cell that converts the energy derived from food into a form that cells can use. And, while most DNA is packaged within chromosomes inside the nucleus, mitochondria have a small amount of their own DNA. Telomeres are the caps at the end of each strand of DNA that protect our chromosomes, just as plastic tips protect the ends of shoelaces.

“Our most notable finding is that the amount of mitochondrial DNA changes in response to stress,” Dr. Jonathan Flint, a professor at the University of Oxford, said in a press release. He further explained how an increase in mitochondrial DNA would indicate a change not only in the mitochondria itself but also in the overall cellular energetics. And so this mood disordermay more properly be viewed as a disturbance of cellular energetics.

Childhood Adversity

Flint and his colleagues made this discovery when searching for genes that increase depression risk. Specifically, they examined a study of thousands of Chinese women, which included participants who had experienced recurrent major depression episodes along with healthy volunteers. Many of the depressed women also had experienced childhood adversity, including sexual abuse. Upon examining and comparing the samples from these two groups, the researchers discovered something surprising.

The samples received from women with a history of stress-related depression — those who had experienced childhood adversity — contained more mitochondrial DNA than the samples from healthy women.

“We were surprised,” said Flint, “so surprised it took us a long time to convince ourselves it was real.”

Next, the researchers evaluated and compared telomere length within the women’s samples. These caps at the ends of chromosomes — just repeated DNA sequences, in actuality — are known to shorten with each cell division (and so with age). Because changes in metabolism are known to alter the rate of aging, the researchers wondered whether depression might similarly change telomere length.

Sure enough, the depressed women had shorter telomere length compared to the healthy volunteers.

Finally, Flint and his colleagues decided to test these results in laboratory mice. Placing them through four weeks of stress, the researchers proved not only that stress caused molecular changes, but also these changes were partly reversible if they administred the stress hormone corticosterone. For this reason, Flint believes depression might be a metabolic reaction to stress.

Having taken a snapshot of the relationship between molecular markers and depression, Flint and his colleagues now “want to know how they change over time — before, during, and after a depressive illness.”

In other words, if molecular changes do serve as biomarkers of stress, the researchers believe it could be possible to use a decline in mitochondrial DNA levels as an indicator of success following treatment for depression. Someday, too, a molecular signature might be a preventive clue so that doctors might help someone who experienced childhood adversity from suffering future physical illnesses.

Source: Cai N, Chang S, Li Y, et al. Molecular signatures of major depression. Current Biology. 2015.

The Absolutely 12 Worst Cancer Causing Products In Your Home .


Every day we`re in contact with potentially harmful substances which can be serious threat for our health, without being aware of that. We rely on the labels to ensure that the product we use is safe. Sometimes, we do not even know the meaning of the ingredients listed on those labels. Here is a list of 12 different products can cause cancer:

 

 

Talcum Powder ( John & Johnson. Inc.)

cancer-1Labeled Toxic Ingredient:

Talc- potential cause for ovarian cancer and lung irritation.

 

Cover Girl Replenshing Natural Finish Make Up ( Foundation) ( Procter & Gamble. Inc.)

Labeled Toxic Ingredients:

cancer-2TRIETHANOLAMINE (TEA), In interaction with nitrites forms carcinogenic nitrosamines.

LANOLIN, frequently contaminated with carcinogenic pesticides and DDT.

BHA, Carcinogenic.

PARABENS, Contact dermatitis.

FRAGANCE, Various toxic, untested and unlabeled ingredients as well as contact dermatitis.

TALC, Lung irritation, carcinogenic.

 

Crest Tartar Control Toothpaste- ( Procter & Gamble. Inc.)

cancer-3Labeled Toxic Ingredients:

FD&C BLUE #1, carcinogenic.

SACCHARIN, Carcinogenic.

FLUORIDE, Potentially carcinogenic.

Alberto VO5 Conditioner (Essence of Neutral Henna)

Labeled Toxic Ingredients:

cancer-4FORMALDEHYDE, Carcinogenic, contact dermatitis, sensitizer and neurotoxic.

POLYSORBATE 80, Contaminated with the carcinogen 1,4-dioxane.

FD&C RED #4, Carcinogenic.

FRAGANCE, Various undisclosed ingredients, contact dermatitis.

 

Clariol Nice `n Easy (Permanent Haircolor) (Clariol. Inc.)

Labeled Toxic Ingredients:

QUARTENIUM-15, releases formaldehyde, carcinogenic, contact dermatitis, sensitizer and neurotoxic.

DIETHANOLAMINE (DEA), in contact with nitrites forms carcinogenic nitrosamine.

PHENYLENE-DIAMINES, contains carcinogens and other ingredients which are inadequately tested for carcinogenicity, contact dermatitis.

PROPYLENE GLYCOL, Contact dermatitis.

FRAGANCE, contact dermatitis, various undisclosed ingredients. Also related to non-Hodgkin`s lymphoma, multiple myeloma and other cancers.

 

Household Products Ajax Cleanser ( Colgate- Palmolive. Inc.)

Unlabeled Toxic Ingredients:

CRYSTALLINE SILICA, Carcinogenic, lung, skin and eye irritation. Note: Silica is admitted as a carcinogenic in 1994 Material Safety and Data Sheet (MSDS). ( Manufacturer claims to have reduces silica since 1993)

 

Zud Heavy Duty Cleanser ( Reckitt & Colman. Inc.)

Unlabeled Toxic Ingredients:

CRYSTALLINE SILICA, Lung, skin and eye irritation, carcinogenic. ( Carcinogenicity is denied in Material and Data Sheet.)

 

Lysol Disinfectant Spray ( Reckitt & Colman. Inc.)

Labeled or Unlabeled Toxic Ingredients:

ORTHOPHENYLPHENOL (OPP), irritant, carcinogenic. ( Carcinogenicity is denied in Material Safety and Data Sheet.)

 

Zodiac Cat & Dog Flea Collar (Sandoz Agro. Inc.).

Labeled Toxic Ingredients:

PROPOXUR, Carcinogenic, neurotoxic.

 

Ortho Weed-B-Lawn Weed Killer (Monsanto Co.)

Labeled Toxic Ingredients:

SODIUM 2,4 DICHLOROPHENOXYACETATE (2,4 D), Carcinogenic, related to lymphoma, soft tissue sarcoma and other cancers, reproductive toxin, neurotoxic.

 

Food Beef Frankfurters- (eg. Oscar Mayer Foods Corporation)

Unlabeled Toxic Ingredients:

BENZENE HEXACHLORIDE, carcinogenic.

DACHTAL, carcinogenic (potentially contaminated with dioxin), strong sensitizer, irritant.

DIELDRIN, carcinogenic, xenoestrogen.

DDT, carcinogenic, xenoestrogen.

HEPTACHLOR, carcinogenic, neurotoxic, reproductive toxin, xenoestrogen.

HEXACHLOROBENZENE, carcinogenic, teratogenic, neurotoxic.

LINDANE, carcinogenic, neurotoxic, damage to blood forming cells.

HORMONES, carcinogenic  and feminizing.

ANTIBIOTICS, carcinogenic, some cause allergies or drug resistance.

Labeled Toxic Ingredients:

NITRITE, in interaction with meat amines forms carcinogenic nitrosamines which are the potential cause for childhood cancer.

 

Whole Milk– (eg. Borden or Lucerne)

Unlabeled Toxic Ingredients:

21009833e7a032c3e7762110l-186x300DDT, carcinogenic, xenoestrogen.

DIELDRIN, carcinogenic, xenoestrogen.

HEPTACHLOR, carcinogenic, xenoestrogen, reproductive toxin, neurotoxic.

HEXACHLOROBENZENE, carcinogenic, reproductive toxin, neurotoxic.

ANTIBIOTICS, some are carcinogenic, cause allergies or resistance.

RECOMBINANT BOVINE GROWTH HORMONE and IGF-1. Potential risk factor for colon, prostate and breast cancer.

Indian Man With Cysts Has World’s Largest Kidneys Removed, Each The Size Of A Newborn Baby


 Surgeons extract kidney size of newborn baby
A man in India breaks a Guinness World Record by having the world’s largest kidneys — each weighing the size of a newborn baby — removed. 

A man in India with severe abdominal pain unexpectedly broke a world record when he was admitted to the emergency room. The 45-year-old unnamed man stunned surgeons during an emergency surgery at Delhi’s Sir Ganga Ram Hospital when they removed a massive 6-pound kidney from his abdomen — 20 times bigger than the normal size. The man’s abnormally large kidney was a result of fluid-filled cysts growing in the organ due to autosomal dominant polycystic kidney disease (ADPKD), an incurable genetic disease.

The pain-stricken man arrived at the hospital with symptoms of a high fever, blood in his urine, and severe abdominal pain. He admitted his body felt drained due to the severe blood loss. “I used to remain tired throughout the day due to excessive blood loss,” he said, theDaily Mail reported.

Dr. Manu Gupta, a consultant and urological surgeon at the hospital admitted the emergency operation was a difficult task for him and his team. “It took us three hours and a difficult dissection to remove the kidney that weighed 2.75 kg — 20 times more than normal. It was even more complicated because the kidney was stuck to the surrounding intestines,” he toldThe Times of India.

A week later, Gupta removed the man’s other kidney that weighed 5.5 pounds. Both kidneys extracted at the hospital broke the Guinness World Record of the largest kidneys removed. The previous record was the removal of a 4.7-pound kidney which measured 13.28 x 5.57 x 5.93 inches in Dhule, India, in 2011. Normal kidneys typically weigh one-quarter pound.

Abnormal kidney growth is common for patients with ADPKD. The genetic condition causes multiple kidney cysts to develop and slowly begin to enlarge the kidney. They replace normal healthy tissue, which causes the kidneys to stop working, says the National Institutes of Health. These cysts can also go unnoticed until adulthood. Although symptoms vary by individual, they include back or abdominal pain, recurring urinary infections or blood in the urine, kidney stones, and kidney failure.

In several cases, specifically this ADPKD patient, pre-transplant nephrectomies – the removal of the kidneys — is necessary. Vinant Bhargav, consultant nephrologist at the hospital, reassured the patient is doing well. “The patient is recovering well now and awaiting kidney transplant,” he told the Indo-Asian News Service.

If the kidney transplant is from a living donor, he has about a 98 percent one-year survival rate and 90 percent for at least five years.

Scientists urge moratorium after Chinese ‘edit’…


Global scientists on Thursday renewed calls to halt controversial research to genetically edit human embryos after a Chinese team published details of a breakthrough attempt in this new frontier in science. A paper by Junjiu Huang, a gene-function researcher at Sun Yat-sen University in Guangzhou, and his colleagues appeared in a little known online journal called Protein and Cell. In the paper researchers describe how they changed the genomes of embryos obtained from a fertility clinic.

Let’s stop that work on human fertilized embryos – a very limited aspect of this – until we have had a chance to talk about it.

Edward Lanphier, chief executive officer of Sangamo BioSciences

When rumors began circulating earlier this month about the impending publication of the study, some scientists began calling for a halt to the research, while others argued that basic research should continue, to see if it may one day help cure certain diseases and disorders. The International Society for Stem Cell Research said it is “too soon to apply these technologies to the human germ line, the inherited DNA, in a clinical setting, and any research involving the use of human embryos and reproductive cells should be undertaken with care and in accordance with strict ethical guidelines.”

 

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