​GM blood cells to protect tomorrow’s soldiers from bioweapons? — RT News


From the desk of Zedie.

Bone Marrow Transplant an Emerging Option for Adults With Sickle Cell Disease | news@JAMA


Scientist creates deadly, untreatable flu


From the desk of Zedie.

The Science Of The Hangover: Study Explains Why Some People Become Alcoholics


From the desk of Zedie.

Leprosy, Still Claiming Victims – NYTimes.com


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Stem Cells Taught to Self-Organize Thanks to Lessons in Geometry


From the desk of Zedie.

Exosomes from bone marrow mesenchymal stem cells contain a microRNA that promotes dormancy in metastatic breast cancer cells — Ono et al. 7 (332): ra63 — Science Signaling


From the desk of Zedie.

Older sperm donors ‘just as good’



Women should not worry about using sperm from older donors as the success rate is the same as using a younger man’s sperm, researchers say.

The average age of donors has risen in the UK since the right to anonymity was removed in 2005.

Doctors said there was concern about the impact on the odds of a pregnancy.

Experts said only older men with the best sperm could donate, so men as a whole should not see the results as an excuse to delay fatherhood.

A presentation at the European Society of Human Reproduction and Embryology annual conference showed the average age of donors was 26 before the law change and 34 afterwards.

“It is a huge difference,” said Dr Meenakshi Choudhary from the Newcastle Fertility Centre.

“It may concern women, who are already older, who know their chances are lower, that if they go for an older sperm then their chance of a live birth will be further reduced and compromised.”


She analysed data from 39,282 cycles of IVF between 1991 and 2012, concluding that older men had the same success rates as younger men.

Dr Meenakshi Choudhary told the BBC: “It doesn’t matter up to the age of 45 years, there was no decline observed in this study.

“Sperm donors are a select group of the population, they are healthy fertile donors who go through a stringent recruitment criteria.

“Based on this we can say that age does not matter as long as the sperm quality is good.”

‘Men not invincible’

Dr Allan Pacey, a senior lecturer in sperm at the University of Sheffield, said men should not be tempted by complacency.

He told the BBC: “I think there is a perception out there that men are invincible from reproductive ageing – we just need to look at Charlie Chaplin who was 73 when he had his eleventh child.

“We know that as men go above the age of 40 and go into their fifties, their chances of getting a woman pregnant does reduce as a consequence of age.

“I don’t think you can take this data and apply it uncritically to the general population, the advice would still be you should be trying to have a child before the age of 40 or 45.”

Clotting balls ‘may stop bleeding’

Clotting balls ‘may stop bleeding’ http://www.bbc.co.uk/news/health-28087258

From the desk of Zedie.

Higgs boson spills secrets as LHC prepared for return


The LHC has been shut down since 2013 for a programme of upgrades and repairs

It’s nearly time. After shutting down last year for vital repairs and upgrades, the Large Hadron Collider is being prepared for its comeback.

Engineers at Cern in Geneva have begun cooling the huge machine to its operating temperature of -271.3C, which is colder than deep space.

And the accelerator system that supplies the LHC with its proton particle beams – which are smashed together to recreate the conditions just after the Big Bang – is up and running for the first time since 2012.

Teams are working to get the LHC – located in a circular tunnel beneath the French-Swiss border – back online by January 2015 and this time it will operate at its full energy of 14 trillion electron volts.

After the $10bn machine was switched on for the first time in 2008, problems were found with many of the electrical splices between the 1,200 superconducting magnets that bend particle beams around the 27km-long underground ring.

To prevent serious damage, officials decided to run the collider at an energy of seven to eight trillion electron volts – about half what it was designed for.

“Much work has been carried out on the LHC over the last 18 months or so, and it’s effectively a new machine, poised to set us on the path to new discoveries,” said Cern’s director-general Rolf Heuer at the EuroScience Open Forum in Copenhagen this month.

The Higgs boson

Particle trace
  • The Higgs is a sub-atomic particle that was detected at the Large Hadron Collider in 2012
  • It was proposed as a mechanism to explain mass by six physicists, including Peter Higgs, in 1964
  • It imparts mass to other fundamental particles via the associated Higgs field
  • It is the cornerstone of the Standard Model, which explains how particles interact

The low energy run from 2010-2012 was nevertheless sufficient to achieve a key scientific goal: Detecting the elusive Higgs boson particle.

The Higgs is the cornerstone of our current best theory of particle physics – the Standard Model. This is the “instruction booklet” that describes how elementary particles (the smallest building blocks of the Universe) and forces interact.

On 4 July 2012, two years ago this week, Cern announced that a five-decade-long search for the particle, first proposed by Edinburgh-based physicist Peter Higgs and others in the 1960s, had reached its conclusion.

Scientists working on Atlas and CMS, the two huge multi-purpose detectors placed at strategic points around the LHC tunnel, saw the Higgs at a 5-sigma level of significance – the statistical threshold for announcing a discovery.

While the LHC has been sitting idle of late, its scientists have not. They’ve continued to crunch the results from the first science run, and hundreds of them will gather to listen to the latest findings at the ICHEP physics meeting in Valencia, Spain, this week.

Particle physicists have learnt more about the Higgs boson’s behaviour and how well it conforms to predictions. In a paper published last week in the journal Nature Physics, researchers outlined how they have watched the Higgs decay into the particles that make up matter (known as fermions), in addition to those that convey force (bosons), which had already been observed.

This is exactly as the Standard Model predicts. Physicists know that this framework, devised in the 1970s, must be a stepping stone to a deeper understanding of the cosmos. But so far, it’s standing up exceptionally well. Searches at the LHC for deviations from this elegant scheme – such as evidence for new, exotic particles – have come to nothing.

Higgs update, 2012
Physicists packed out the auditorium at Cern to hear the Higgs boson discovery announcement in 2012
Higgs update, 2012
Francois Englert (L), Peter Higgs (R) and other originators of the Higgs boson theory were at Cern to hear the announcement. Englert and Higgs would later win a Nobel Prize for their work
Higgs update, 2012
The announcement was a huge media event too

At ICHEP, other scientists are expected to outline details of a refined mass for the fundamental particle, which has been measured at approximately 125 gigaelectronvolts (GeV). For those outside the particle physics community, this might seem like a minor detail. But the mass of the Higgs is more than a mere number.

There’s something very curious about its value that could have profound implications for the Universe. Mathematical models allow for the possibility that our cosmos is long-lived yet not entirely stable, and may – at some indeterminate point – be destroyed.

“The overall stability of the Universe depends on the Higgs mass – which is a bit funny,” said Prof Jordan Nash, a particle physicist from Imperial College London, who works on the CMS experiment at Cern.

“There’s a long theoretical argument which I won’t go into, but that value is intriguing in that it sits on the edge between what we think is the long-term stability of the Universe and a Universe that has a finite lifetime.”

To use an analogy, imagine the Higgs boson is an object resting at the bottom of a curved slope. If that resting place really is the lowest point on the slope, then the vacuum of space is completely stable – in other words, it is in the lowest energy state and can go no further.

The mass of the Higgs (inside rectangle) may hint at the stability of the Universe

However, if at some point further along this slope, there’s another dip, the potential exists for the Universe to “topple” into this lower energy state, or minimum. If that happens, the vacuum of space collapses, dooming the cosmos.

“The Higgs mass is in that place where it gets interesting, where it’s no longer guaranteed that there are no other minima,” Prof Nash, who works on the CMS experiment at Cern, told the BBC. But there’s no need to worry, the models suggest such a rare event would not occur for a very, very long time – many times further into the future, in fact, than the current age of the Universe.

This idea of a finite lifetime for the cosmos is dependent on the Standard Model being the ultimate scheme in physics. But there is much in the Universe – gravitation and dark matter, for example – that the Standard Model can’t fully explain, so there are reasons to think that’s not the case.

The existence of exotic particles, such as those predicted by the theory known as supersymmetry, would shore up the stability of the Universe in those mathematical models.

But as previously mentioned, searches for these particles, called superpartners, have so far drawn a blank, as have attempts to detect dark matter, extra dimensions, and other phenomena beyond the Standard Model. Hopes that the LHC would allow scientists to lift the veil on a whole new realm of physics have proved optimistic, at least during its initial run.

Electrical connections between the superconducting magnets have been re-soldered
Work in tunnel
Engineers have been working to prepare the machine for a planned re-start at the beginning of 2015

Some versions of supersymmetry have already been all but ruled out by the LHC. But the theory has many forms, depending on how you tweak the mathematical parameters.

“From the theory community’s point of view, this is all very interesting because it fleshes out much better what the first run of the LHC has excluded,” said Prof Dave Charlton, who leads the Atlas experiment at Cern.

“Therefore, it better establishes where we should be looking for new signals next year.”

Assuming the theorists are indeed correct, supersymmetry will have to wait some time longer for its big reveal.

Other hypothesised particles, such as the W prime and Z prime bosons could possibly be detected soon after the LHC returns to particle smashing.

For now, all eyes are on the engineers at Cern. The LHC’s initial switch on was marked by mishaps, including a magnet that buckled in the tunnel during a test in 2007. The following year, another magnet failure caused a tonne of helium to leak out, forcing controllers to shut the machine down just nine days after its big switch-on.

But after the re-start in 2009, the LHC performed flawlessly, and the rest, as they say, is history.

If all goes well, by the end of March 2015 scientists could begin colliding high-energy beams of particles at the LHC.

And that’s when the real fun will begin.


The Standard Model and the Higgs boson

Diagram of the Standard Model

The Standard Model is the simplest set of ingredients – elementary particles – needed to make up the world we see in the heavens and in the laboratory

Quarks combine together to make, for example, the proton and neutron – which make up the nuclei of atoms today – though more exotic combinations were around in the Universe’s early days

Leptons come in charged and uncharged versions; electrons – the most familiar charged lepton – together with quarks make up all the matter we can see; the uncharged leptons are neutrinos, which rarely interact with matter

The “force carriers” are particles whose movements are observed as familiar forces such as those behind electricity and light (electromagnetism) and radioactive decay (the weak nuclear force)

The Higgs boson came about because although the Standard Model holds together neatly, nothing requires the particles to have mass; for a fuller theory, the Higgs – or something else – must fill in that gap