High levels of BPA associated with prostate cancer: study

The human body’s endocrine system and DNA are under constant attack from pollutants like bisphenol-A.

Consumers take for granted what they eat from and what they drink out of. Bisphenol-A (BPA) can still be found in the lining of canned food and in plastic water bottles. For that reason, it’s typically found in urine samples of 90 percent of the US population. Once consumed, inhaled or absorbed, the chemical goes to work, unseen by the human eye, offsetting hormone levels. Inside the body, it becomes a disrupter, a divider, manipulating DNA. In fact, a new study from the Cincinnati Cancer Center found that BPA disrupts cellular division, which can beckon the development of cancer.


High BPA levels associated with prostate cancer

The study, published in PLOS ONE, linked high levels of BPA in men to their prostate cancer. Previously, BPA has been studied for its devastating neurological effects and its contribution to diabetes and obesity. Disrupting important glands and hormone levels, BPA is a threat to the body’s harmonic, balanced state of being.

While modern cancer treatments rely on burning and radiating the body, both its good cells and cancer cells, there remains little research on how to prevent cancer by cleansing the body of pollutant chemicals like BPA. Understanding the mechanisms of cellular disruption by chemicals like BPA may be a more constructive approach to treating cancer. In fact, this study may open the eyes of medical professionals, prompting them to betray prostate cancer drugs and instead seek to help patients remove and avoid the very chemical that is perpetuating the prostate cancer.

BPA levels generally 2-4 times greater in cancer patients

Lead author of the study, director of the Cincinnati Cancer Center, Shuk-mei Ho, recognizes this correlation first hand. In an interview, he stated, “The BPA level found in cancer patients is about two- to four-fold higher than the median level found in larger population studies in America.”

In the study, a team of researchers from the University of Cincinnati Medical Center analyzed urine samples from 60 men at the center’s urology clinic. Direct connections were made between higher levels of BPA and prostate cancer. The researchers mentioned that the study only measured one-time exposure, since BPA is excreted from the body within one day. They did, however, mention that daily exposure to BPA can cause higher levels in the body.

“If a person has high levels [of BPA] in his urine, it suggests they’re pretty consistently exposed to it,” Ho said.

The widespread use of BPA took off about 50 years ago; it is derived from polycarbonate manufacturing. Working in a polycarbonate manufacturing plant typically increases BPA levels to 10 to 20 times greater than normal exposure levels. The lifestyle habit of drinking from plastic water bottles also welcomes higher levels of BPA.

Professor Ho, who calls for earlier prostate cancer readings for adults, can detect the cancer early. Looking at BPA levels in the urine, professionals like Ho can help patients understand the need to remove chemicals like BPA from their lifestyle before further action should be taken. In the end, though, the responsibility is up to the adult. It’s easy for some to drink from BPA plastic bottles on a daily basis and not give the habit a second thought.

BPA causes abnormal distribution of DNA during cell division

BPA is one of the chemicals involved in disrupting a person’s DNA over time. When the researchers went a step further, they noticed that cell division is disrupted when BPA is introduced. In a cell model study, they compared normal and cancerous prostate cells and the biomarkers involved in cancer development. In normal cell division, two “daughter cells” are formed as DNA chromosomes divide equally between the new cells. When the researchers placed BPA into the midst, the DNA was abnormally distributed.

“It seems that BPA, even at very low doses, can disrupt the way DNA is partitioned between two daughter cells — the potential basis for cancer promotion or initiation,” Ho said.

“These are very early studies, but I think [their] importance is as a warning sign,” Ho said. “Because other studies have shown that lifestyle changes can change BPA levels, this really offers… a positive hope of potential ways of diminishing exposure.”

In this study of chemical exposure, professionals investigated the devastating role that environmental toxin splay on normal, healthy genes. When women are told to cut off their breasts or cut out their ovaries because they have a predisposition to cancer, when men are told to cut out their prostate, they should question their doctor and despise the idea, seeking to rule out environmental factors such as BPA exposure first.

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