Tribute to Nelson Mandela.


http://m.bbc.co.uk/news/blogs-echochambers-25247907

Radiation bomb that could wipe out Aids from sufferers body.


http://www.dailymail.co.uk/news/article-2517904/Radiation-bomb-wipe-Aids-sufferers-body.html

Slippery fault unleashed destructive Tohoku-Oki earthquake and tsunami


http://m.phys.org/_news305472239.html

Calcified fetus.


http://radiopaedia.org/cases/calcified-fetus

What Causes the Rise of ADHD in Children?


http://articles.mercola.com/sites/articles/archive/2013/12/05/adhd-glyphosate.aspx

Scientists Just Sequenced the DNA From A 400,000-Year-Old Early Human.


http://blogs.smithsonianmag.com/science/2013/12/scientists-just-sequenced-the-dna-from-a-400000-year-old-early-human/?utm_source=twitter.com&utm_medium=socialmedia&utm_campaign=12052013&utm_content=facebook4000yearold

WHO | New Zealand: Kiringaua


http://www.who.int/disabilities/policies/spinal_cord_injury/kirinagua/en/index.html

Study Links Aspartame To Fast-Paced Decline in Kidney Function.


http://www.minds.com/blog/view/97660/study-links-aspartame-to-fast-paced-decline-in-kidney-function

Should Statins Be Used for Primary Prevention in Women?


Women, even those without evidence of atherosclerotic cardiovascular disease, should be treated with statin therapy if their baseline risk justifies use, according to one expert. Although the randomized clinical trial evidence supporting primary prevention with statin therapy in women is not perfect, “the absence of data means negative data.”

That is the argument formulated by Dr Noel Bairey Merz (Cedars Sinai Medical Center, Los Angeles, CA), who spoke today here at the American Heart Association 2013 Scientific Sessions.

“How confident are we that statins do not save lives in the week before a heart attack, but they do save lives the week after a heart attack, for women and men?” asked Merz. “This remains the controversy, as you can read in the New York Times. There are even people saying that no men should take statins for primary prevention, and that’s something I don’t agree with either.”

Stop More Than the Presses

On Monday morning, a front-page story on the New York Times blared: “Risk Calculator for Cholesterol Appears Flawed.” Reporter Gina Kolata quotes Dr Steven Nissen (Cleveland Clinic, OH), who earlier spoke with heartwire about  the new guidance, as saying, “We need a pause to further evaluate this approach before [the guidance] is implemented on a widespread basis.”

That, says Kolata, is because the risk calculator used extends statins to “millions more people.”

The problems with the calculator are reportedly going to be described in a commentary in the Lancet by Dr Paul Ridker (Brigham and Women’s Hospital, Boston, MA) and Dr Nancy Cook (Harvard Medical School, Boston, MA), to be published Tuesday. Cook and Ridker reportedly sent a letter to the National Heart, Lung, and Blood Institute (NHLBI) outlining their concerns a year ago, saying that the risk calculator did not work—commentary the writing committee reportedly never received.

The concerns will no doubt be hashed out in full over the next few days, including at a special session on the guidelines Wednesday morning.

 

I would say that it’s time to stop the controversy and do a trial.

 

During the presentation in a special session devoted to controversies in cardiovascular risk reduction, Merz referred to the November 13, 2013 editorial in the New York Times by Dr John Abramson, author of Overdosed America: The Broken Promise of American Medicine, and Dr Rita Redberg (University of California, San Francisco). In the editorial, Abramson and Redberg take aim at the new guidelines by the American College of Cardiology (ACC) and AHA, developed in conjunction with the NHLBI, that recommend physicians abandon cholesterol targets and focus on four groups of patients, including those without existing cardiovascular disease but a 10-year risk>7.5%, for treatment with statin therapy.

According to Abramson and Redberg, “even though the guidelines recommend that women between the ages of 45 and 75 at increased risk of heart disease and with relatively high LDL levels take statins, the fine print in the 284-page document admitted, ‘Clinical trials of LDL lowering generally are lacking for this risk category.’ “

The Data, Firm and Not So Firm

During the AHA session, Merz, a coauthor of the new cholesterol guidelines, said that the benefit of statins in secondary prevention is firmly established in men and women, each having an approximately 30% reduction in the risk of cardiovascular events with treatment. The risk reduction in primary prevention in women, however, remains controversial. One meta-analysis, performed in 2004, showed there was a nonsignificant reduction in cardiovascular risk among 11 000 women treated with a statin.

However, in 2010 an analysis of 6801 women led by Dr Samia Mora (Brigham and Women’s Hospital, Boston, MA), which included the JUPITER study, showed that statin therapy does provide a primary prevention benefit to women. In a gender-specific analysis of JUPITER , rosuvastatin (Crestor, AstraZeneca) significantly reduced the relative risk of the primary end point—a composite of MI, stroke, revascularization, hospitalization for unstable angina, and death from cardiovascular causes—by 46%. The decrease was driven by a reduction in the risk of revascularization and hospitalization for unstable angina.

“What do we value?” asked Merz. “Do we not value the reduction in revascularization and hospitalization in angina, meaning morbidity and cost? Isn’t that a justification for the use of statins in primary prevention? Don’t we hear all the time that cardiovascular disease is the most expensive use of our healthcare dollars?”

For Redberg, who in 2012 also authored a perspective arguing against the use of statins in primary prevention, especially in women, the drugs simply do not reduce the risk of death in those with a 10-year risk of heart disease <20%. Also, in the overall JUPITER study of 18 000 patients, there was no treatment benefit when women were studied as a subgroup. Merz argues that JUPITER is powered for the total sample size only, not for women alone. In addition, the statistical test for heterogeneity revealed the interaction by sex was not statistically significant.

“Pretty much all the subgroups fall beyond the statistically significant range,” said Merz. “So should we withhold treatment for women, who now are the majority of victims of cardiovascular disease, because of low precision and a trial that was not designed to address or answer this question?”

Stop the Debate: Do a Trial in Women Only

During the presentation, Merz conceded that the evidence isn’t perfect and that there are no clinical trials of statin use in women alone. She said that such trials should be done and noted that the National Institutes of Health (NIH) spent $674 million in 2010 on breast-cancer research, a disease that claims 40 000 lives annually, but only $173 million on women-specific cardiovascular funding—a pittance for a disease that claims the lives of 419 000 women annually.

“I would say that it’s time to stop the controversy and do a trial,” said Merz.

Dr Allan Sniderman (McGill University, Montreal, QC), who commented on the controversy during the AHA session, praised the contrarians, such as Abramson and Redberg, arguing that it is reasonable to express an opinion in an area of medicine that has uncertainty. He said he agreed with the AHA/ACC/NHLBI recommendations and noted that even the expert panel concluded the evidence was inadequate.

“We’re always required to think, and I approve of thinking,” he said to laughs. “You stipulate that a trial should be done, and I approve of that. But it seems to me that we will get along with each other better if we agree to accept the limitations of evidence and reason together on how best to proceed.”

How Old is Too Old to Start Treatment?

In addition, other presentations tackled controversies in the field of cholesterol lowering, including Dr Jennifer Robinson (University of Iowa, Iowa City) who addressed the question: How old is too old to start a primary-prevention patient on statin therapy? For patients >75 years without clinical cardiovascular disease, randomized, controlled clinical trial data supporting the statin use is thin. In JUPITER, a study that included 5695 patients >70 years, there was a 30% reduction in the primary end point.

“At least in JUPITER, statins look like a good idea in older people,” she said.

Robinson added that because of patient comorbidities in older patients, the use of statins does require some thought. The clinical guidelines do not make a strong recommendation for statins in these older primary-prevention patients, mainly because there is a wide divergence in patient function. If the patient is in good health, they would probably benefit from a statin, said Robinson.

New ACC/AHA/NHLBI Guidance on Lifestyle for CVD Prevention.


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Cardiologists and other healthcare professionals have waited years for the updated National Heart, Lung, and Blood Institute (NHLBI)–sponsored guidelines on cholesterol, blood pressure, and obesity management in adults. Today, with the release of (most of) these updates—albeit in a new form—come two new guidance documents, one on assessing CV risk and another tackling one of the most fundamental but frequently overlooked issues: lifestyle[1].

The 2013 AHA/ACC Guideline on Lifestyle Management to Reduce Cardiovascular Risk, chaired by Dr Robert Eckel(University of Colorado, Anschutz Medical Campus) and Dr John Jakicic (University of Pittsburgh, PA), is published alongside three other sets of ACC/AHA coordinated guidelines in both the Journal of the American College of Cardiology and Circulation. The lifestyle guidelines, as with the other guidelines, are accompanied by a companion document representing the “NHLBI Systematic Review.”

Key Recommendations

Speaking with reporters, Eckel explained that the aim of the lifestyle guidelines was to “reevaluate and update the concept of a healthy lifestyle,” with the specific aim of preventing progression to cardiovascular disease in at-risk patients.

As such, the recommendations cover evidence related to dietary patterns, nutrient intake, and levels and types of physical activity that play “a major role in cardiovascular disease prevention and treatment through effects on modifiable CVD risk factors,” namely high LDL cholesterol and hypertension, he said.

The lifestyle guidelines, as with the other NHLBI-sponsored documents, were intended for use by primary-care doctors as well as subspecialists, Eckel emphasized. While the full guidelines run 45 pages in length, there are three major findings:

·         Eat a dietary pattern that is rich in fruit, vegetables, whole grains, fish, low-fat dairy, lean poultry, nuts, legumes, and nontropical vegetable oils consistent with a Mediterranean or DASH-type diet.

·         Restrict consumption of saturated fats, trans fats, sweets, sugar-sweetened beverages, and sodium.

·         Engage in aerobic physical activity of moderate to vigorous intensity lasting 40 minutes per session three to four times per week

Of note, the writing group “did not have the time or resources” to investigate other aspects of lifestyle and diet—namely calcium, magnesium, and alcohol intake; cardiorespiratory fitness; single behavioral intervention or multicomponent lifestyle interventions; the addition of lifestyle intervention to pharmacotherapy; and smoking. These may, however, have “potential benefits,” Eckel said.

In tables spelling out the specific guidelines, recommendations are broken out according to whether an adult in question has higher-than-desirable lipid profiles or higher-than-desirable blood-pressure levels, although the recommendations for both groups are very similar.

Low-Fat Diets Give Way to Mediterranean

Of particular note, the guidelines emphasize Mediterranean-style dietary patterns over a “low-fat dietary pattern,” which is scarcely mentioned in the document, although “low-fat dairy products” are part of the dietary pattern advice. There are no specific recommendations to reduce overall fat consumption, only to reduce the percent of calories consumed from saturated and trans fats.

Also notable are the recommendations on sodium. The general recommendation to “reduce sodium intake” is given a level of evidence A (strong), in the NHLBI grading system or a class IA by the ACC/AHA grading system. By contrast, advice to further restrict sodium intake to 1500 mg/day as “desirable” is given level of evidence B (moderate)/class IIa-B.

Dr Alice Lichtenstein (Tufts University, Boston, MA), a coauthor on the guidelines, noted that mean daily sodium intake in the US is about 3.5 g. “We’re all consuming too much sodium . . . and it’s absolutely critical to reduce it.” However, she continued, “accurately assessing sodium intake is extremely difficult and probably clouds the whole issue, as does the [use of a] specific target.

“What we really need to emphasize is that most of the sodium consumed is consumed as processed foods, so just focusing on a salt shaker on the table is not going to result in the reductions we want to see. Therefore, we really need a concerted effort and a partnership with public-advocacy organizations like the ACC and [the AHA] and the food industry to reduce sodium content in general across the board.”

Eckel, also responding to heartwire ‘s question about sodium targets, said that the working group did review evidence looking at specific sodium targets, “and there is evidence that people who cut back a gram a day do have lower blood pressures.”

Keep in mind, he continued, that these lifestyle recommendations are intended for people already identified as having a problem, and in the case of sodium recommendations, that means people with ‘prehypertension” or hypertension. “If the question is, does the [sodium intake] level make a difference? Yes, absolutely. . . . Sodium reduction is an important element of successful blood-pressure lowering. What level should be achieved? I think as low as possible is beneficial, but targeted levels are supported moderately by the evidence that exists and should not be the initial message that we give to our patients at risk.”

This will be the last time the guidelines per se will be called “NHLBI” guidelines. The NHLBI announced in June 2013 that it was getting out of the guideline-writing business, choosing instead to focus on the “evidence review and synthesis.”

Asked why the NHLBI guideline planners originally took the step of adding a “lifestyle document,” Eckel, who led the Lifestyle Working Group for the past five years, told heartwire : “We felt from the very beginning that lifestyle could stand alone in addition to being a component of the updated guidelines for cholesterol and BP. Thus, what we’ve accomplished is in [the] cholesterol [guidelines] and I presume will remain in [the blood-pressure guidelines] once they appear.”