Professor Brandon Wainwright said these genes provided potential targets for treatment.
“Brain tumours are the most common cause of cancer death in children,” Professor Wainwright said.
“Those who do survive often experience significant neurological, intellectual and physical disabilities as a result of their treatment, which involves surgical removal of the tumour followed by radiotherapy and chemotherapy.
“We clearly need more effective and less invasive options to treat medulloblastoma and improve outcomes for both children and adults with this devastating disease.”
There are four different sub-types of medulloblastoma, each with their own molecular signature.
The researchers identified underlying genetic regulatory networks that were present in all of the sub-types, a discovery that Professor Wainwright said was important in advancing treatments.
“We are now searching for existing drugs that may block these gene networks and act as viable treatment alternatives for medulloblastoma.”
The results were published in the highly prestigious scientific journal Proceedings of the National Academy of Sciences USA.