CARTOONS FOR MEDICAL LEARNING.


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Aloe Vera Juice and its wonders.


Aloe Vera is a common plant found in the garden of each and every Indian house, also it is famous only for the moisturizing abilities which is why it forms the main element of several beauty products across the world. There are many people who surely know that the secret for beautiful women in the world Cleopatra is said to be goat milk but there are very few people who know that even Aloe Vera is the secret for her beauty.

Benefits-of-Aloe-Vera-Juice-300x189

It is a known fact that aloe vera grows perfectly in climate which is warm and dry hence there are many botanists who believe that this plant has its origins from deserts of Africa where the climate suits this plant’s growth. Apart from this the reason for availability of this plant across entire world so much is its ability to adapt to any nature apart from this people also have taken up the duty of carrying this plant from one place to other in order to gain advantages from this plant even in various other areas.

Though there is no duty taken up by anyone to officially promote this plant it can be surely said that aloe vera still stands to be hugely getting recognition across the world for being the main ingredient in healing any burns and bruises. However this does not mean that aloe vera has to be applied externally instead the juice extracted from aloe vera has to be included in the diet though it might leave the mouth with bitter taste.

However with the several advantages it has to offer it can be surely said that there are people who are willing to leave this bitter taste in their mouth for some time. For all those who are aware of cocktail might be happy to know that taking aloe vera juice will be something similar to a cocktail of vitamins and minerals like Vitamin A, B1, B2, B6, B12, C, E, Niacin and Folic acid. Well this is not the end to advantages since there are even minerals like Sodium, Iron, Copper, Calcium, Magnesium, Potassium, Chromium and Manganese along with 19 other amino acids among which 8 of which cannot be produced by the body on their own.

Also taking in aloe vera juice before meal will make help the body in getting all the necessary nutrients from the food being consumed, further it also increases the absorption of several vitamins which are taken daily. However it is not necessary for a glass of juice to be consumed but it will be sufficient to take 80gms of juice 3 times in a day to do its work on the body.

Here we are to give you detailed benefits that can be gained from this plant and its juice:

1.   Helps in weight loss:

Presence of an element named collagen in Aloe Vera is the one responsible to feeding those cells present in hair and skin, also it is not easy to digest hence needs lot of energy for digestion resulting in losing lots of weight. For all those who have tried several weight losing methods should once give a try to aloe vera juice.

 

1.   Boosts Immunity:

Anti-oxidants present in aloe juice are found to provide full support to the immunity system which helps in fighting free radicals and environment pollutants throughout the day. This juice also is said to regulate the process in which our body’s immune system works.

 

1.   Treats Constipation:

People suffering with constipation can drink aloe vera juice after which it is necessary to wait for about 10 minutes to see the result, also this juice is known to help in bowel movement and treating chronic constipation. However it is also suggested to see that this juice will not be taken in larger quantities which otherwise will cause damage to the intestine lining.

 

1.   Anti-inflammation:

Aloe Vera is found to have 12 substances which constrain inflammation apart from this it is also being considered best medicine for people suffering with arthritis, therefore reducing any swelling or pain in the joint.

 

1.   Improves digestion:

Aloe Vera juice helps our digestive system by ensuring that the body takes in all the necessary nutrients by increasing bowel movements. This juice also lessens the development of bacteria and yeast in the gut, apart from which it helps in lessening the heartburns and any other problems in digestive system.

 

1.   Treat diabetes:

If aloe vera juice is taken for 3 continuous months it has been proved that this will help in treating diabetes by having a check on the sugar levels. Apart from controlling diabetes it is also known to increase blood circulation and taking a reverse turn of sludge blood.

 

1.   Get beautiful skin:

As informed in the start of this article presence of collagen is enough to help in keeping a check on the skin health, collagen is the main element which provides nutrition to the skin also preventing skin ageing. Aloe vera also is best medicine to cure minor cuts, burns or any skin irritation.

It is better to add aloe vera juice in the diet however it has to be taken care that this juice should not be consumed more than 2 to 4 oz daily which when crossed with result in allergic reactions or nausea which is also felt when vitamins are taken in huge quantities.

Source: http://greenyatrablog.com

South African Student Invents Waterless Bathing.


When finding a steady source of portable water is challenge enough in the developing world who has the time  – or water- to take a shower? One South African student may have the answer with a unique, water-less shower gel—that he invented on his dumb phone.

DryBath, as the gel is called, was developed by 22 year old college student Ludwick Marishane in response to the rankness of a friend. Rubbed onto the skin, like Purell, the gel kills bacteria, moisturizes the skin and, unlike Purell, leaves a fresh scent, according to Marishane’s company website, Headboy Industries. One packet—priced at $0.50 for rural communities, $1.50 for corporate types—is enough to wash the entire body and kill 99.9-percent of germs, which should cut down on the disease rate in rural areas onset by by poor hygiene. Marishane also sees the technology being adopted by militaries, hotels, and even airlines.

What’s really amazing is that Marishane brought the product to market using only his feature phone. From the initial research to building his business plan to developing the patented blend of biocide, bioflavonoids and moisturizers, he did it all without a computer.

Watch the video. URL: http://www.youtube.com/watch?feature=player_embedded&v=lR6jVPQPydg

Source:  http://www.educateinspirechange.org

 

How Does a Quantum Computer Work?


Watch the video.

URL: http://www.sciencealert.com.au/index.php?option=com_jusertube&view=video&rid=g_IaVepNDT4&yuser=PLI-6-wtgFSgC-nbpwvkTbTICySA2shfkV&auto=1&eh=385&ew=600&st=yes&height=500&width=600

Source: science alert

 

Wisconsin Seeks to Jail Raw Milk Farmer After Jury Finds Him Innocent.


On May 20, Hershberger’s trial began at the Sauk County Courthouse. He was charged with four criminal misdemeanors for supplying a private buying club with raw milk and other fresh produce.

  1. Operating a retail food establishment without a license
  2. Operating a dairy farm as a milk producer without a license
  3. Operating a dairy plant without a license
  4. Violating a holding order by removing the members’ food from the embargoed refrigerators

amish

However, since Hershberger only supplies food to paid members in a private buying club, he has long maintained that he is not subject to state food regulations, and jurors must have agreed.

On May 25, he was acquitted of three charges of producing, processing and selling milk without state licenses. They did, however, find him guilty of violating a holding order, which required that he not sell any food or milk from his store as a condition of his bail.

Following a Capital Times online article in which it’s reported that Hershberger stated he had continued to supply his buying club members with fresh food all along, the Wisconsin Department of Justice (DOJ) filed a motion to revoke Hershberger’s bail and instead send him to jail – after he’d already been acquitted!

Fortunately, Hershberger will not be going to jail for this “crime,” as on June 13 he was sentenced to pay a $1,000 fine plus $513 in court costs – avoiding jail time, probation and the maximum possible fine of $10,000.

Still, the fact that the motion was filed in the first place is deeply disturbing. The Cornucopia Institute reported:1

“Hershberger’s attorney, Glenn Reynolds, called the motion very disappointing because the bail terms he’s accused of violating are the same activities that led to the charges of which he was acquitted. ‘It seems vindictive in my view,’ he said. ‘He goes to trial and wins and now they want to put him in jail? What is the point of this sort of motion?’”

What’s the point is a very good question, indeed, as it seems clear the state is trying to take a stand against Hershberger for example’s sake … but why?

How Can They Continue to Claim This Is About Safety?

One of the most common excuses given for why farmers are raided, prosecuted, and shut down is that raw foods may be potentially harmful to human health. But those buying these products are doing so willingly, in many cases travelling great distances to access these fresh-from-the-farm foods.

Wisconsin is not doing these food buyers any favors by taking away their right to fresh food. Instead, they are taking a stand against Hershberger because his acquittal could have a major impact on increasing raw milk sales in the state. As noted by the Farm-to-Consumer Legal Defense Fund (FTCLDF):2

“‘There is more at stake here than just a farmer and his few customers,’ says Hershberger, ‘this is about the fundamental right of farmers and consumers to engage in peaceful, private, mutually consenting agreements for food, without additional oversight.'”

Back in 2010, after weeks of lobbying by the Wisconsin dairy industry, former Wisconsin Governor Jim Doyle vetoed a bill that would have made sale of on-the-farm raw milk legal, stating he “must side with public health and safety of the dairy industry.”

But high-quality raw milk is no more a threat to public health than sunshine or natural supplements (against which similar “public-safety” wars have been aged). CDC data3 shows there are about 412 confirmed cases of people getting ill from pasteurizedmilk each year, while only about 116 illnesses a year are linked to raw milk. And research by Dr. Ted Beals, MD, featured in the summer 2011 issue of Wise Traditions,4 the quarterly journal of the Weston A. Price Foundation, shows that you are about 35,000 times more likely to get sick from other foods than you are from raw milk!

So when officials say they are siding with public health and the safety of the dairy industry, they are really only siding with the dairy industry, in an attempt to protect them from all competition. The reason why small-scale organic, raw dairy farms are so threatening to the dairy industry is because they simply cannot produce safe raw milk in a confined animal feeding operation (CAFO). Cows raised under such conditions produce milk that must be pasteurized in order to be safe to drink, as the unnatural diet and environment dramatically alters the nutritional and bacterial composition of the milk, making it otherwise unfit to drink.

The FDA Is Leading the War Against Raw Milk

State-level efforts against raw milk are only part of a larger problem, which is the US Food and Drug Administration’s (FDA) 25-year-old regulation banning raw milk for human consumption in interstate commerce. But even this is up for challenge. Pete Kennedy, president of FTCLDF wrote:

“At the federal level, a bill that would repeal the interstate ban has been introduced the last two sessions of Congress and will likely be reintroduced this session; the bill would allow raw milk to be taken across state lines either by consumers or their agents who obtain it in another state or by producers or their agents delivering it to consumers in another state. The bill would not affect the power of states to determine whether the sale of raw milk would be illegal within its borders.”

Currently, legislation that would either legalize or expand the sale of raw milk has been introduced in Arkansas, Hawaii, Iowa, Indiana, Kansas, Massachusetts, Montana, Oklahoma, Rhode Island, Texas, Vermont, and Wyoming. A bill is also expected to be filed shortly in Wisconsin, according to Kennedy. Many are simply getting fed up with the FDA and their state governments trying to dictate what its residents are allowed to eat. This is not an issue of a few “rogue” farmers trying to sell an illegal product; it’s an issue of food freedom. Kennedy continued:

“The fight over raw milk stands as a symbol of the much larger fight for food freedom. Who gets to decide what you eat? You? Or the FDA? If the FDA and state agencies are allowed to impose their view of ‘safe food’ on consumers, raw milk won’t be the only thing lost – all our food will be pasteurized, irradiated, and genetically engineered. The effort to reclaim our right to buy and consume raw milk is leading the way for everyone who wants to be able to obtain the food of their choice from the source of their choice.”

Right now, your food freedom is on the chopping block. In North Dakota, a new bill threatens to make herdshare illegal.5 In New Mexico, a bill has been introduced that would ban the sale of raw milk, while a proposed regulation in Illinois that is currently in the drafting stage would similarly restrict access to raw milk. So the time to take action is now

Stand Up for Your Right to Food Freedom

Source: mercola.com

 

Ecosystem Threatened by ‘Gross Underestimate’ of Toxicity of Neonicotinoids.


Nicotine-related compounds called nicotinoids were initially introduced as a new form of pesticide in the 1990s, as widespread pest resistance rendered many older pesticides useless. Many seeds are now “pre-treated” with neonicotinoids, which are water-soluble and break down slowly in the environment.

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Today, they are the most widely-used pesticides in the world. In fact, you’d be hard-pressed to find a pesticide that does not contain at least one neonicotinoid insecticide. In California alone, there are nearly 300 registered neonicotinoid products available.

The American Bird Conservancy (ABC), one of the leading bird conservation organizations in the US, is now calling for a ban on the use of neonicotinoids as seed treatments, and wants all pending applications for neonicotinoid products to be suspended pending an independent review of the products’ effects on birds, terrestrial and aquatic invertebrates, and other wildlife.

As reported by the American Bird Conservancy1:

“It is clear that these chemicals have the potential to affect entire food chains. The environmental persistence of the neonicotinoids, their propensity for runoff and for groundwater infiltration, and their cumulative and largely irreversible mode of action in invertebrates raise significant environmental concerns…”

ABC commissioned the world renowned environmental toxicologist Dr. Pierre Mineau to conduct the research, which resulted in a 100-page report2 titled The Impact of the Nation’s Most Widely Used Insecticides on Birds. Mineau’s report reviews 200 studies on neonicotinoids, including industry research obtained through the US Freedom of Information Act.

The report concludes that neonicotinoids “are lethal to birds and to the aquatic systems on which they depend.” Even more disturbing, contamination levels in both surface and ground water around the world are already beyond the threshold found to kill many aquatic invertebrates. According to this shocking toxicology assessment:

  • A single kernel of corn treated with this type of pesticide can kill a songbird
  • A single grain of wheat or canola treated with the neonicotinoids Imidacloprid can be fatal to a bird
  • As little as 1/10th of a neonicotinoid-coated corn seed per day during egg-laying season can affect a bird’s reproductive capability

EPA Accused of Failing to Adequately Assess Environmental Risks

Disturbingly, the US Environmental Protection Agency (EPA) has not adequately assessed the toxicity of neonicotinoids. Part of the problem, according to the featured report, is that the EPA is “using scientifically unsound, outdated methodology that has more to do with a game of chance than with a rigorous scientific process.” This has led the agency to grossly underestimate the toxicity of these chemicals. Furthermore3:

“The report also charges that there is no readily available biomarker for neonicotinoids as there is for cholinesterase inhibitors such as the organophosphorous pesticides.

‘It is astonishing that EPA would allow a pesticide to be used in hundreds of products without ever requiring the registrant to develop the tools needed to diagnose poisoned wildlife. It would be relatively simple to create a binding assay for the neural receptor which is affected by this class of insecticides,’ said Dr. Mineau.”

Dr. Mineau urges the EPA to require pesticide registrants to also provide the diagnostic tools necessary to diagnose cases of wildlife poisonings. So far, neonicotinoids have garnered the most attention and criticism for their role in bee die-offs—a worldwide phenomenon that took off once these newer pesticides became widely used. As stated by ABC4:

“The serious risk to bees should not be understated, as one-third of the US diet depends on these insect pollinators. The ABC assessment makes clear, however, that the potential environmental impacts of neonicotinoids go well beyond bees.”

Link Between Neonicotinoids and Bee Die-Off is ‘Crystal Clear,’ Lawsuit Maintains

A general consensus among beekeepers is that the bee die-offs are most definitely related to toxic chemicals, and neonicotinoids in particular. The disappearance of bee colonies began accelerating in the United States shortly after the EPA allowed these new insecticides on the market in the mid-2000s. In May, beekeepers and environmental groups filed a lawsuitagainst the agency over its failure to protect bees from these toxic pesticides.

Meanwhile, France has banned Imidacloprid for use on corn and sunflowers after reporting large losses of bees after exposure to it. They also rejected Bayer´s application for Clothianidin, and other countries, such as Italy, have banned certain neonicotinoids as well.

Neonicotinoids are used on most of American crops, especially corn. As mentioned earlier, these chemicals are typically applied to seeds before planting, allowing the pesticide to be taken up through the plant’s vascular system as it grows. As a result, the chemical is expressed in the pollen and nectar of the plant, and hence the danger to bees and other pollinating insects… Needless to say, since the chemical is taken up systemically through the plant, it could also pose potential health risks to anyone eating the plant since it cannot be rinsed off.

Neonicotinoids affect insects’ central nervous systems in ways that are cumulative and irreversible. Even minute amounts can have profound effects over time. One of the observed effects of these insecticides is weakening of the bee’s immune system. Forager bees bring pesticide-laden pollen back to the hive, where it’s consumed by all of the bees. Six months later, their immune systems fail, and they fall prey to secondary, seemingly “natural” bee infections, such as parasites, mites, viruses, fungi and bacteria.

The EPA5 acknowledges that “pesticide poisoning” may be one factor leading to colony collapse disorder, yet they have been slow to act to protect bees from this threat. The current lawsuit may help spur them toward more urgent action, which is desperately needed as the food supply hangs in the balance.

In March, the EPA sent Jim Jones, overseer of the Office of Chemical Safety and Pollution Prevention, to talk to California almond growers and beekeepers, as mass die-offs of bees were seriously threatening this year’s almond crop. But although beekeepers said Jones got the message that bees are in serious trouble, they were dismayed by the fact that he seemed more interested in finding new places for bees to forage rather than addressing the issue of toxic pesticides…

As usual, at the core of the problem is big industry, which is blinded by greed and enabled by a corrupt governmental system that permits the profit-driven sacrifice of our environment. Unfortunately, this motivation reflects an extreme shortsightedness about the long-term survival of the human race, as well as of our planet. Clearly, if the goal of pesticides is to increase food yield to more easily feed 7 billion human beings, this goal falls flat on its face if it leads to the collapse of our food chain.

Pesticides Again Tied to Parkinson’s Disease

A recent meta-analysis published in the journal Neurology6, examined data from 104 studies published between 1975 and 2011, in search for a potential link between pesticides and Parkinson’s disease. As many previous studies, it found one… Parkinson’s disease is a neurological disorder in which neurons in a region within your brain responsible for normal movement begin to die, causing the telltale shaking and rigidity associated with the disease. There’s currently no known cure, which makes preventing the disease all the more important. Mounting evidence suggests avoiding pesticides is an important part of prevention. As reported by Reuters7:

“In 2011, a study of US farm workers from National Institutes of Health found some pesticides that are known to interfere with cell function were linked to the development of Parkinson’s disease. Another study that was published in 2012 also reported that people with Parkinson’s disease were more likely to report exposure to pesticides, compared to people without the condition.”

In this latest analysis, exposure to pesticides was linked to a 58 percent increased risk of developing Parkinson’s. Some pesticides were clearly worse than others. Paraquat (a non-selective plant killer) and two fungicides, maneb and mancozeb, were found to double your risk. One of the study’s authors told Reuters that8:

“[T]he study’s results suggest that people should avoid contact with pesticides or – at least – wear proper protection when handling the chemicals. The use of protective equipment and compliance with suggested, or even recommended, preventive practices should be emphasized in high-risk working categories (such as farming).”

How Modern Farming Methods Have Led to Toxic Food Supplies

Chlorinated hydrocarbons, or organochlorines like DDT were developed after World War II and remained widely used in agriculture for pest and weed control until Rachel Carson’s book Silent Spring was published in 1962. That book is credited with beginning the modern environmental movement, and through the involvement of scientists and ordinary concerned citizens many of the organochlorines were later phased out of use, according to the conditions of the Stockholm Convention of 19819. Since then, these chemicals have been replaced by a slew of new herbicides, pesticides and fungicides designed to kill the things that threaten a farmer’s bottom line.

These include not just neonicotinoids, but also glyphosate—the active ingredient in Monsanto’s herbicide Roundup.

Roundup was designed to be used in conjunction with Monsanto’s genetically engineered “Roundup Ready” seeds, which in turn have been genetically altered to withstand otherwise lethal doses of the chemical. This way, only the non-modified weeds die while the crop survives the indiscriminate sprayings. In theory, genetically engineered seeds were supposed to reduce the use of agricultural chemicals. It didn’t work out that way. Today, resistant “superweeds” are taking over large swaths of farm land, and in an effort to stay on top of increasing weed resistance, farmers using Monsanto’s genetically engineered (GE) seeds have progressively started using more and more Roundup.

The increased pesticide residue remains in the foods that wind up on your dinner table, as glyphosate is taken up systemically throughout the plant and cannot be washed off.

About 90 percent of the corn produced in the US is genetically engineered, and GE soybeans account for almost 95 percent of US production. In other words, if you’re eating non-organic corn or soybeans in the United States, you’re eating a genetically engineered crop that’s been repeatedly and thoroughly drenched in glyphosate. The same applies to eating meats from animals raised in confined animal feeding operations (CAFOs), as they’re typically fed GE grains.

The danger to you and your children is very real, according to the latest research. While Monsanto insists that Roundup is safe and “minimally toxic” to humans, a recent report published in the journal Entropy10 argues that glyphosate residues, found in most commonly consumed foods in the Western diet courtesy of GE sugar, corn, and soy, “enhance the damaging effects of other food-borne chemical residues and toxins in the environment to disrupt normal body functions and induce disease.” According to the authors:

“Negative impact on the body is insidious and manifests slowly over time as inflammation damages cellular systems throughout the body.”

The main finding of the report is that glyphosate inhibits cytochrome P450 (CYP) enzymes, a large and diverse group ofenzymes that catalyze the oxidation of organic substances. This, the authors state, is “an overlooked component of its toxicity to mammals.” One of the functions of CYP enzymes is to detoxify xenobiotics—chemical compounds found in a living organism that are not normally produced or consumed by the organism in question. By limiting the ability of these enzymes to detoxify foreign chemical compounds, glyphosate enhances the damaging effects of those chemicals and environmental toxins you may be exposed to—including other pesticides.

How You Can Avoid Toxic Pesticide Exposure

First and foremost, to limit your exposure to the most common agricultural chemicals, such as neonicotinoids and glyphosate, you want to buy as much fresh organic produce as possible, as synthetic chemicals are not allowed on organic crops. For a good guide to which conventionally grown produce carry the lowest pesticide residues, and which you’re best off buying organic due to their heavy pesticide load, see my recent article, How to Find the Healthiest Fare in Meat and Produce Aisles.

Since years’ worth of these toxins now pollute our soils and waterways, including the sources of most if not all human drinking water, I also recommend investing in a good water filtration system for your home or apartment to ensure you are drinking the purest water possible. Also consider a shower filter, as they may actually cause more damage to your body through your skin than from drinking unfiltered water. Additional recommendations to limit your exposure to toxic pesticides and herbicides include:

  1. Grow your own food. While this may be a challenge for many, nearly everyone, even those with a studio apartment or a dorm room can easily grow sprouts that can serve as a large percentage of the organic vegetables that you eat.
  2. Detoxify your lawn. If you have a lawn care service, make sure they are not using the organophosphate pesticide trichlorfon. Also, avoid using Roundup to control weeds around your home.
  3. Clean out your shed. The pesticide diazinon (sold under the brand names Diazinon or Spectracide) has been banned from residential, but there might be some left in your old garden shed.
  4. Use natural cures for a lice infection. Malathion is used for treatment of head lice. Don’t put a neurotoxin on your child’s head.
  5. Check your school’s pest control policy. If they have not already done so, encourage your school district to move to Integrated Pest Management, which uses less toxic alternatives.

Source: mercola.com

 

 

 

ACIP Updates Guidelines for Preventing Measles, Mumps, and Rubella.


The Advisory Committee on Immunization Practices has updated its guidelines for prevention of measles, mumps, rubella, and congenital rubella syndrome.

The revisions, published in MMWR, include:

  • All patients aged 12 months and over with HIV infection who don’t have severe immunosuppression should be vaccinated against measles, mumps, and rubella (MMR).
  • Patients with perinatal HIV who received their MMR vaccination before antiretroviral therapy was started should be revaccinated with two doses.
  • The use of immune globulin administered intramuscularly (IGIM) is now recommended for infants aged birth to 6 months who’ve been exposed to measles. In immunocompetent patients, the recommended dose of IGIM has increased.
  • Intravenous immune globulin is recommended for severely immunocompromised people and for pregnant women who have been exposed to measles but who don’t have evidence of immunity.

Source: MMWR

 

Public Health Officials Urge Meningococcal Vaccination in MSM Ahead of NYC’s Gay Pride.


Several health departments are recommending that men who have sex with men (MSM) receive meningococcal vaccinations before traveling to New York City following an outbreak of invasive meningococcal disease there. The city is expecting as many as 1 million people to attend gay pride events at the end of June, public health experts note in theAnnals of Internal Medicine.

Since 2010, 22 MSM have contracted invasive meningococcal disease in New York. Seven of those cases have been fatal. The city already recommends vaccination for all men who’ve had “intimate contact with a man met through an online Web site, digital application or at a bar or party.” Over 11,000 people have been vaccinated, and there have been no new confirmed cases since February. Los Angeles, meanwhile, has had four cases since December.

The authors urge clinicians to be aware of the outbreak and discuss it with their MSM patients.

Source: Annals of Internal Medicine

 

Statin Toxicity Associated with CYP3A4-Inhibiting Antibiotics .


Higher rates of hospitalization for rhabdomyolysis occur among patients on statins who also start taking clarithromycin or erythromycin, which inhibit statin metabolism, according to an Annals of Internal Medicine study.

Using provincial databases, researchers examined 30-day outcomes among some 140,000 Ontario residents who were taking a statin metabolized by the cytochrome P450 isoenzyme 3A4 (CYP3A4). All participants were aged 66 or older. Roughly half were starting a prescription for the CYP3A4-inhibiting antibiotics clarithromycin or erythromycin, and the other half were starting azithromycin.

CYP3A4-inhibiting antibiotics were associated with a 0.02% increase in absolute risk for hospitalization with rhabdomyolysis, the study’s primary outcome, compared with azithromycin (relative risk, 2.17). Increased risks for acute kidney injury and all-cause mortality were also noted.

The authors recommend that coprescribing a CYP3A4-metabolized statin (atorvastatin, simvastatin, or lovastatin) and a CYP3A4-inhibiting antibiotic (clarithromycin or erythromycin) “be avoided when possible.”

Source: Annals of Internal Medicine