Endocrine Treatment Toxicity in Breast Cancer: A Good Thing?


Specific adverse effects were associated with treatment benefit, but further confirmation is needed.

 

Recent studies have shown that in postmenopausal women with hormone-receptor–positive breast cancer, the benefits of adjuvant endocrine therapy seem to be associated with the adverse effects of the treatment (e.g., Lancet Oncol 2008; 9:1143).

To examine this association further, investigators conducted a phase III, multinational, open-label, randomized study of 9766 postmenopausal women with estrogen-receptor–positive or progesterone-receptor–positive breast cancer who were eligible for adjuvant endocrine treatment. Patients received either the aromatase inhibitor (AI) exemestane (25 mg daily for 5 years) or tamoxifen (20 mg daily for 2.5–3 years), followed by exemestane (25 mg daily for 2.5–2 years; sequential regimen).

Patients who reported vasomotor symptoms during the first year of treatment achieved longer disease-free survival (DFS) and longer overall survival (OS) than those who did not experience those symptoms. Women who reported musculoskeletal symptoms also achieved superior DFS but not OS. These findings were independent of endocrine therapy assignment.

Comment: These findings of a correlation between toxicity and treatment benefit are intriguing. However, other large studies have reported discordant results (e.g., J Clin Oncol 2011; 29:51s). Only by prospectively controlling for baseline symptoms, concurrent medications, and treatment adherence and by capturing toxicity with validated instruments can a link between adverse effects and treatment success be confirmed. Until then, the search for a biomarker that can identify patients most likely to benefit from adjuvant therapy remains.

Source: Journal Watch Oncology and Hematology

 

 

 

Subclinical Atrial Fibrillation Is Common in Patients with Cryptogenic Stroke.


An implantable loop recorder established new diagnoses of atrial fibrillation in 25% of patients with cryptogenic stroke.

One third of ischemic strokes remain cryptogenic even after thorough inpatient evaluation. Numerous studies suggest that some of these patients may have paroxysmal atrial fibrillation (AF) that remains undiagnosed during their stroke hospitalization. Failing to detect these cases of AF may result in suboptimal antithrombotic therapy. However, what type and duration of cardiac monitoring should be used to rule out subclinical AF remain unclear.

To address this question, investigators placed implantable loop recorders (ILRs) in 51 patients who had received standard stroke evaluations, including vascular imaging, echocardiography (transthoracic in all patients and transesophageal in 30), and at least 24 hours of Holter monitoring without evidence of AF. The ILR software automatically detected AF episodes 2 minutes in duration. Two cardiologists independently reviewed any AF episodes detected by ILRs.

ILRs were implanted an average of 174 days after stroke. In 13 patients (25.5%), AF was detected after a median 48 (range, 0–154) days of monitoring. The other patients remained AF-free throughout an average 229 days of monitoring. AF was associated with older age, more-frequent premature atrial contractions during baseline Holter monitoring, and larger left atrial size.

Comment: In the recently completed EMBRACE trial, 15% of cryptogenic stroke patients assigned to 30-day external loop recorder monitoring received new diagnoses of atrial fibrillation, versus 3% of patients assigned to 24-hour outpatient Holter monitoring. It is possible but unlikely that some of these poststroke episodes of AF are incidental, because subclinical AF lasting only a few minutes has recently been shown to increase stroke risk, and the majority of cryptogenic strokes appear radiographically to have resulted from cardiac embolism. On these bases, several weeks of noninvasive cardiac monitoring should usually be performed in patients with cryptogenic stroke. The current study results suggest that longer periods of monitoring might detect even more cases of AF. However, relatively invasive and expensive implantable loop recorders cannot be routinely recommended until we see the results of the ongoing CRYSTAL-AF trial, which is comparing use of ILRs to routine clinical follow-up in patients with cryptogenic stroke.

 

Source:Journal Watch Neurology

The #1 WORST Food that HARMS Your Brain.


http://csglobe.com/the-1-worst-food-that-harms-your-brain/

Two One-Pill Regimens Face Off.


The integrase-based option performed as well as the old efavirenz-based standby.

 

Now that three single-tablet regimens are available for HIV treatment, competition for the “best” option is intense. In phase III trials comparing efavirenz/FTC/tenofovir (Atripla) and elvitegravir/cobicistat/FTC/tenofovir (Stribild), the two regimens were equally safe and efficacious at week 48 (JW AIDS Clinical Care Jul 9 2012). Longer-term results from one of these trials are now available. The study was sponsored by the maker of elvitegravir/cobicistat/FTC/tenofovir.

Seven hundred treatment-naive HIV-infected patients with genotype-confirmed viral susceptibility to efavirenz, tenofovir, and FTC were randomized to receive either elvitegravir/cobicistat/FTC/tenofovir or efavirenz/FTC/tenofovir along with a placebo version of the other. At week 96, the rates of virologic suppression were similar between groups (84% for elvitegravir/cobicistat/FTC/tenofovir and 82% for efavirenz/FTC/tenofovir), as were the rates of virologic failure (6% and 8%). CD4-cell counts increased similarly in the groups.

Overall rates of adverse events were also comparable, with nausea more common in the elvitegravir/cobicistat/FTC/tenofovir group, neuropsychiatric events more common in the efavirenz/FTC/tenofovir group, and rates of treatment-limiting side effects similar between groups (5% and 7%, respectively). Treatment-limiting renal toxicity from cobicistat was seen in two patients during the second 48 weeks of treatment.

Overall rates of genotypic resistance in patients with virologic failure were similar; most participants with failure on elvitegravir/cobicistat/FTC/tenofovir had developed integrase-resistance mutations, and most of those with failure on efavirenz/FTC/tenofovir had the K103N nonnucleoside reverse transcriptase inhibitor–resistance mutation.

Comment: By all the usual standards, efavirenz and elvitegravir/cobicistat perform equally well for initial antiretroviral therapy, at least when combined with FTC/tenofovir. The high efficacy rates seen with both options is doubtless testimony to their tolerability and to the good adherence seen with single-dose regimens.

Source: Journal Watch HIV/AIDS Clinical Care

HIV cure months away, Danish scientists say, citing novel new DNA treatment.


dna_test_twinsDanish scientists believe they may have a cure for HIV “within months.”

Danish scientists believe they may have a cure for HIV “within months.”

Researchers at Aarhus University Hospital in Denmark are testing a new technique that involves flushing the virus from so-called reservoirs in human DNA.

The virus is then destroyed naturally by the body’s immune system, The London Telegraph reported.

They are expecting results to show that “finding a mass-distributable and affordable cure to HIV is possible”.

Fifteen patients are taking part in the trials, funded with $2.1 million from the Danish Research Council.

If they are found to have successfully been cured of HIV, the new technique will be tested on a wider scale.

Any cure would be affordable for many of the 33 million people worldwide afflicted by the virus.

However, despite the trials Dr. Ole Sogaard, a senior researcher in the department of infectious disease warned that the efficacy in the human body remained unproven.

Medical Daily quoted him as telling the media:

“The challenge will be getting the patients’ immune system to recognize the virus and destroy it. This depends on the strength and sensitivity of individual immune systems.”

British researchers are reportedly conducting similar research through a consortium of five universities.

Both studies are aiming to find a cure for those already infected with the virus and would not result in a preventative measure for HIV or AIDS.
Source: http://www.globalpost.com

5 Foods that Lower Cholesterol Naturally.


http://www.rd.com/slideshows/5-foods-that-lower-cholesterol-naturally/?buffer_share=1d531&utm_source=buffer&utm_medium=twitter&utm_campaign=Buffer%253A%252Breadersdigest%252Bon%252Btwitter

Source: RD

Is Stress Toxic? 9 Reasons Why You Should Give Up Stress.


http://www.purposefairy.com/4774/is-stress-toxic-9-reasons-why-you-should-give-up-stress/

Measles: The MMR scandal shows us why science matters.


http://www.telegraph.co.uk/health/children_shealth/10022124/Measles-The-MMR-scandal-shows-us-why-science-matters.html

A fertilizer that cannot detonate bombs.


researchers-with-sandia-national-laboratories-create-a-non-detonable-fertilizer

The key to fertilizer bombs is the ammonium nitrate.

When mixed with a fuel like diesel, this agricultural staple becomes the highly explosive, raw ingredient for many improvised explosive devices (IEDs).

Now, researchers from Sandia National Laboratories have developed a fertilizer that can’t detonate a bomb. And Sandia has decided not to patent or license the formula. Instead, they’re waiving ownership rights, making it freely available in hopes of saving lives, according to a press release earlier this week.

Ammonium nitrate was used in the 1995 Oklahoma City bombing and in 65 percent of the 16,300 homemade bombs in Afghanistan in 2012. The Department of Defense’s Joint Improvised Explosive Device Defeat Organization issued a call last year for ideas on how to neutralize ammonium nitrate as an IED explosive.

Sandia’s Kevin Fleming came up with a fertilizer formula that’s as good as ammonium nitrate in helping plants grow — but nonexplosive.

The ammonium ion is only weakly attached to the nitrate ion, and the ions can be separated by adding a compound they would rather cling to. Iron sulfate is a readily available compound that steel foundries throw away by the tons.

When mixed with ammonium nitrate, the iron ion “grabs” the nitrate and the ammonium ion takes the sulfate ion. Iron sulfate becomes iron nitrate and ammonium nitrate becomes ammonium sulfate. This reaction occurs if someone tries to alter the fertilizer to make it detonable when mixed with a fuel.

“The ions would rather be with different partners,” Fleming explains. “The iron looks at the ammonium nitrate and says, ‘Can I have your nitrate rather than my sulfate?’ and the ammonium nitrate says, ‘I like sulfate, so I’ll trade you.’”

Ammonium sulfate and iron nitrate are not detonable, even when mixed with a fuel.

Iron sulfate in fertilizer adds iron and helps neutralized soil pH. And it wouldn’t cost more to produce.

Source: Smart Planet

 

GE Trees May Be Even More Damaging to the Environment than GE Foods.


Genetic engineering (GE) of our food supply amounts to a massive science experiment being performed on mankind, without consent or full disclosure. Although the biotech industry continues to claim GE products are safe, the truth is that no one knows what the long-term effects will be, because no one has done the necessary studies.

The loudest proponents of GE are the ones who stand to profit the most, and they don’t seem terribly concerned about the human or environmental costs.

What do we know for certain? We know genetic engineering is riddled with unpredictable effects… so we should expect the unexpected.

You may not realize that this reckless genetic experimentation is not limited to your food supply. Besides being used to create drugs and “Frankenfish,” they’ve also created vaccine-containing bananas, goats that produce spider silk in their milk, venomous cabbage, chemotherapy chicken eggs, and even glow-in-the-dark cats.1

As creepy as some of these things are, the application that may have the greatest potential for global disaster are GE trees created to serve the desires of the paper industry.

Deforestation is already an enormous problem, and the last thing we need is to further stress our precious native forests and the flora and fauna that depend on them.

The documentary featured above discusses how GE trees may adversely impact ecological systems on a grand scale, with potentially catastrophic effects. A Silent Forest: The Growing Threat, Genetically Engineered Trees is hosted by Dr. David Suzuki,2 an award-winning geneticist and author of 52 books.

‘The Greatest Threat to Native Forests Since the Chain Saw’

As Dr. Suzuki explains, the problem with genetic engineering has to do with the fact that GE plants and animals are created using horizontal gene transfer (also called horizontal inheritance), as contrasted with vertical gene transfer, which is the mechanism in natural reproduction.

Vertical gene transfer, or vertical inheritance, is the transmission of genes from the parent generation to offspring via sexual or asexual reproduction, i.e., breeding a male and female from one species.

By contrast, horizontal gene transfer involves injecting a gene from one species into a completely different species, which yields unexpected and often unpredictable results. Proponents of GE assume they can apply the principles of vertical inheritance to horizontal inheritance, and according to Dr. Suzuki, this assumption is flawed in just about every possible way and is “just lousy science.”

Genes don’t function in a vacuum — they act in the context of the entire genome. Whole sets of genes are turned on and off in order to arrive at a particular organism, and the entire orchestration is an activated genome.

It’s a dangerous mistake to assume a gene’s traits are expressed properly, regardless of where they’re inserted. The safety of GE is only a hypothesis, and in science, initial hypotheses typically end up being wrong. GE foods are promoted as if they’ve been found to be safe, which is the farthest thing from the truth.

Why this rush to apply this science before testing it? The simple answer is, those promoting it stand to profit enormously from it. The timber, pulp, bioenergy, and fruit industries are rushing ahead with GE trees, with only their paydays in mind. As the film states:

Genetic engineering of trees is the greatest threat to the native forests since the invention of the chain saw.”

Why Genetically Engineer Trees?

Trees as being genetically engineered to give them unnatural characteristics, such as the ability to kill insects, tolerate toxic herbicides, grow abnormally fast, or have altered wood composition. The paper pulp industry has to remove lignin from wood pulp before it can be used to make paper, which is an expensive part of the process. So, the biotech industry is working to create trees with lower lignin content. The problem is, lignin is what gives trees their structural integrity.

It’s what allows trees to stand strong in wind and other weather, and to withstand diseases and damage from insect and animal browsing. Low lignin trees are weaker and less able to withstand these environmental stresses. Dead low-lignin trees also decompose faster, releasing carbon dioxide into the atmosphere more quickly, which contributes to climate change.

The best thing for trees is to not use them for paper. Paper doesn’t need to be made from wood pulp, because there are more Earth-friendly materials such as agricultural wastes, recycled material, hemp, tobacco and even banana leaves.

Fruit trees are being genetically engineered for disease resistance. However, contamination of wild and organic fruit trees by genetically altered DNA has already had devastating consequences on nearby groves. For example, GE papaya plantations have contaminated much of the organic and wild papaya trees in Hawaii.3 Nearly 20,000 papaya seeds from the Big Island and Oahu revealed GMO contamination. Eighty percent of the seeds tested were from organic farms, and the remainder were from wild trees and backyard gardens.

Contamination with GE DNA has caused many organic Hawaiian papaya growers to lose their plantations and/or their organic certification. Hawaiian GE papayas have now begun developing black spot fungus, so they have to be heavily sprayed with toxic fungicides every 10 days.

This is so typical of what happens to GE plants — they are weaker and more susceptible to disease and end up needing massive amounts of chemicals, usually in the form of herbicides and pesticides — to remain viable. This is particularly tragic because there ARE so many far superior alternatives. Later this year, I will be reviewing many of the newer high performance agriculture techniques that far surpass virtually ANY benefit of GMO technology. I am currently identifying the leading experts in the US in this area.

It is crucial to have an alternative to the increasingly pervasive GMO technology as the list of adverse health effects from these toxic chemicals is growing all the time. For example, the herbicide glyphosate (the active agent in Roundup) has been linked to miscarriages, premature births, and non-Hodgkin’s lymphoma. The only winner in this scenario is the biotech industry because it manufactures both the GE seeds and the toxic chemicals required to grow them. The biotech industry has created the problem, as well as the “solution” that makes them rich.

The Spread of Seed and Pollen Is Uncontrollable. Period.

Genetically engineered trees vastly differ from other annual GE crops like corn and soybeans because trees can live for decades and even centuries in the wild. Once GE trees escape the confines of their plantation, they are extremely difficult to eradicate. For this reason, the risks, regulation and assessment needs of GE trees are even greater than those of agricultural GE products like corn and soy.

Disrupting forest ecosystems endangers the health of the entire planet. Native forests have been called the “lungs of the earth,” providing food and wildlife habitats everywhere. Forests absorb carbon dioxide and produce oxygen, filter water and release it back into the atmosphere. Many tree species, such as pines and poplars, can spread their pollen and seeds over great distances. Pollen can blow hundreds or even thousands of miles, opening the door for native forests to be dusted with GE pollen.

The contaminating of native forests is both inevitable and irreversible, according to the Global Justice Ecology organization.4Some tree varieties are widespread throughout the world, and some are able to interbreed with similar species. Some tree types are highly invasive, such as Eucalyptus, a “bully” that has spread out of control across California. Once wild tree species are contaminated, GE trees could take over vast geographical areas, and there is no do-over! You can recall a bad drug, but you can’t recall a bad tree.

Industry’s Answer to Cross-Contamination: The Terminator Gene

The biotech industry realized tree contamination would be a problem, so they developed the “terminator gene.” This gene causes the plant to produce a toxin that’s supposed to prevent its seeds from being viable, thereby preventing cross-contamination. Like the Terminator’s promise “I’ll be back,” Mother Nature trumps human ingenuity when it comes to nature’s drive to reproduce. Even the originators of the terminator gene admit it’s impossible to ensure 100 percent sterility.

The problem is, even a small amount of slippage can spread sterility to our native forests.

Consider the scenario of a native forest sitting adjacent to a GE tree plantation. Once contaminated, 95 percent of the native forest trees may become sterile, meaning they would produce no nuts, no seeds, no fruit, and no flowers or pollen. This renders the forest uninhabitable to native wildlife and rapidly degrades the soil. This phenomenon is already being seen around the 100 to 150 GE tree test plots5 in the southern part of the US.

Monsanto’s Love Child, ArborGen

GE tree plantations may threaten to destroy global ecosystems and local farmers’ livelihoods, but they promise to make the biotech industry rich. Genetically engineered trees and other crops become the property of the company that patented the seeds from which they grew. Monsanto has stolen more than 15 million dollars from farmers whose crops were contaminated by no fault of their own.

Once a farmer’s crop is contaminated, they can be sued by Monsanto, which manufactures the majority of the world’s GE seed. Even if only one percent of the crop is contaminated, patent law dictates that Monsanto gains possession of 100 percent of the crop. If this patent law goes unchallenged, ALL of the world’s natural resources could end up owned exclusively by biotech industry magnates.

The majority of GE research and development on trees has come from a company called ArborGen, the industrial “love child” from a tryst between Monsanto, International Paper, Westvaco and Fletcher Forests.6 Although Monsanto dropped out of the partnership early on, ties between Monsanto and ArborGen remain.

Barbara Wells, who was ArborGen’s CEO and President from 2002 to 2012, spent 17 years with Monsanto and headed its RoundUp Ready Soy division in Brazil. Similar parallels exist with ArborGen’s new CEO, Andrew Baum, and its VP of Business and Product Development, David Nothmann — who also happens to serve on committees in the Department of Energy and USDA.

The government has doled out numerous grants — well over $1 billion — to bioenergy companies and scientists to further the development of new bioenergies, many of which center on GE. The USDA is doing everything it can to hasten the approval of GE technology and silence the opposition. According to Global Justice Ecology:

“In April 2011, the USDA announced a new plan that would allow biotech companies to conduct their own environmental assessments. Under the National Environmental Policy Act, the USDA is responsible for studying the environmental risks of GMOs. Part of the strategy of the USDA’s new plan is to speed up the deregulation process and take it out of the public arena, reducing the ability of GMO watchdog groups to weigh in. This plan is a direct result of the numerous cases that the USDA has lost in court due to their poorly conducted environmental assessments of potentially dangerous GMOs.

On February 22, 2012, the USDA announced a plan to cut in half the review time for new GMO products from 3 years to 13-16 months. Part of this acceleration would be accomplished by accepting public comments after making the final decision in the Environmental Assessment, eliminating any real ability for the public to have input.”

Final Thoughts

GE tree plantations threaten to spoil native forests, displace local farmers, and destroy sustainable economies. Self-sufficient communities will be forced to leave their lands and find livelihoods elsewhere. Pollen and seeds from GE trees are impossible to control, even with “terminator gene” technology, and find a way to cross-pollinate wild trees with grim ecological consequences. Pollen from GE trees may also cause brand new allergies that we may or may not be able to successfully address. Despite the obvious dangers, the profit-driven biotech industry, with the full backing of the US government, is pushing GE trees forward with ever-increasing zeal. That said, there are some things YOU can do to help preserve our precious native forests:

  • Refrain from buying paper products made from trees/wood pulp; instead, buy recycled paper (toilet paper, tissue paper, writing paper, computer paper); Greenpeace and NRDC have handy downloadable guides for buying recycled, Earth-friendly paper products
  • Eliminate your need for toilet paper altogether by installing in a bidet
  • Say no to napkins, especially when you’re handed a stack of them; use cleaning cloths instead of paper towels
  • Cut back on printing; ask yourself if you really need to print a document; use both sides of a paper before tossing it; use old receipts for notes; reuse wrapping paper, or make your own from newsprint or magazines
  • Opt out of the yellow pages7

For more information about GE trees, visit Global Justice Ecology. To sign the Petition to Prohibit GE Trees, or Donate to the Global Justice Ecology Project, visit globaljusticeecology.org/petition.php. And be sure to support GMO labeling campaigns.

Keep Fighting for Labeling of Genetically Engineered Foods

While California Prop. 37 failed to pass last November, by a very narrow margin, the fight for GMO labeling is far from over. The field-of-play has now moved to the state of Washington, where the people’s initiative 522, “The People’s Right to Know Genetically Engineered Food Act,” will require food sold in retail outlets to be labeled if it contains genetically engineered ingredients. As stated on LabelitWA.org:

“Calorie and nutritional information were not always required on food labels. But since 1990 it has been required and most consumers use this information every day. Country-of-origin labeling wasn’t required until 2002. The trans fat content of foods didn’t have to be labeled until 2006. Now, all of these labeling requirements are accepted as important for consumers. The Food and Drug Administration (FDA) also says we must know with labeling if our orange juice is from fresh oranges or frozen concentrate.

Doesn’t it make sense that genetically engineered foods containing experimental viral, bacterial, insect, plant or animal genes should be labeled, too? Genetically engineered foods do not have to be tested for safety before entering the market. No long-term human feeding studies have been done. The research we have is raising serious questions about the impact to human health and the environment.

I-522 provides the transparency people deserve. I-522 will not raise costs to consumers or food producers. It simply would add more information to food labels, which manufacturers change routinely anyway, all the time. I-522 does not impose any significant cost on our state. It does not require the state to conduct label surveillance, or to initiate or pursue enforcement. The state may choose to do so, as a policy choice, but I-522 was written to avoid raising costs to the state or consumers.”

Remember, as with CA Prop. 37, they need support of people like YOU to succeed. Prop. 37 failed with a very narrow margin simply because we didn’t have the funds to counter the massive ad campaigns created by the No on 37 camp, led by Monsanto and other major food companies. Let’s not allow Monsanto and its allies to confuse and mislead the people of Washington and Vermont as they did in California. So please, I urge you to get involved and help in any way you can, regardless of what state you live in.

  • No matter where you live in the United States, please donate money to these labeling efforts through the Organic Consumers Fund.
  • If you live in Washington State, please sign the I-522 petition. You can also volunteer to help gather signatures across the state.
  • For timely updates on issues relating to these and other labeling initiatives, please join the Organic Consumers Association on Facebook, or follow them on Twitter.
  • Talk to organic producers and stores and ask them to actively support the Washington initiative.
  • Source: mercola.com