Endometriosis Associated with Inflammatory Bowel Disease.

Women with endometriosis had elevated risk for ulcerative colitis and Crohn disease, even more than 20 years after their diagnoses.

Endometriosis is the result of implantation of menstrual products from the endometrium that are not cleared by the immune system. To determine whether endometriosis is associated with inflammatory bowel disease (IBD) — also an autoimmune-related disorder — investigators in Denmark conducted a nationwide cohort study involving 37,661 women (mean age, 38.6 years) hospitalized with endometriosis during a 40-year period.

During >492,000 person-years of follow-up, the standardized incidence ratio was 1.5 for ulcerative colitis and 1.6 for Crohn disease. The risk for ulcerative colitis was highest among women diagnosed with endometriosis between the ages of 25 and 34. The risk for Crohn disease was highest among women diagnosed before age 25. The mean interval between endometriosis diagnosis and diagnosis of IBD was 10.8 years for ulcerative colitis and 9.8 years for Crohn disease. Risks for IBD remained elevated after >20 years of observation and were even higher when the analysis was confined to women with surgically verified endometriosis.

Comment: These data suggest a shared immunologic basis for endometriosis and IBD. Patients with endometriosis and clinical features associated with IBD should undergo gastrointestinal evaluation.

Source:Journal Watch Gastroenterology


One thought on “Endometriosis Associated with Inflammatory Bowel Disease.

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

This site uses Akismet to reduce spam. Learn how your comment data is processed.