Ectopic recurrent craniopharyngioma of the frontal bone.

Ectopic recurrence of craniopharyngioma is a rare phenomenon after transcranial resection of the primary tumor. The authors present a case of ectopic recurrent adamantinomatous craniopharyngioma of the frontal bone resected 16 years after initial transcranial resection of the primary tumor. The lesion was first radiographically described 12 years after surgery and was adjacent to the osteosynthesis plate that had been implanted at the craniotomy site. The recurrent craniopharyngioma was totally resected via a lateral eyebrow approach. No infiltration of the meninges or the brain was detected.

Only 50 cases of ectopic recurrent craniopharyngioma have been described to date, with the present case being the first one with recurrence located at the skull bone. So far 2 mechanisms have been described: contamination with tumor cells alongside the surgical tract and spreading via CSF and the subarachnoid space.

The authors reviewed the literature, provided the largest collection of cases so far, and performed basic statistical analysis regarding ectopic recurrence. Pediatric and adult patients as well as male and female ones are affected equally by this phenomenon. The mean time of ectopic recurrence after initial surgery was 7.1 years. Ectopic recurrence, although rare, should always be considered in a patient with a newly diagnosed intracranial lesion who has undergone transcranial craniopharyngioma resection before.

Source: Journal of Neurosurgery.


Justifying referrals for paediatric CT.


  • The system of radiation protection assumes a linear dose–response relationship with no threshold for low doses and dose rate exposures. This is based on epidemiological evidence at higher doses.
  • Hence there is a small theoretical risk of carcinogenesis attributable to low doses of ionising radiation. This risk is associated with any diagnostic imaging procedure involving radiation.
  • Radiosensitivity declines with age, so children are more susceptible to radiation risks than adults. Females are more radiosensitive than males.
  • The radiation protection system is based on the assumption that radiation risk is cumulative over a lifetime.
  • For an individual, a justified, optimised computed tomography (CT) scan will result in more benefit than harm. A doctor must justify the necessity for a CT scan before referring an individual for imaging.

An adolescent female patient presents with acute lower back pain of recent onset and no history of trauma. Is it warranted to order a computed tomography (CT) scan of her lumbar spine? The justification for a CT scan at the individual level is complex and the risk–benefit ratio must be considered; the risks associated with radiation are often not well understood and, similarly, the benefit for an individual may be difficult to determine.

Adverse outcomes of CT scans (in addition to radiation-induced cancer) may include false-positive scan results, unnecessary treatment due to overdiagnosis, and anxiety for the patient or their family. Benefits can be significant and include diagnosis, treatment, changes to management, and disease surveillance. Even a null finding on a CT scan may provide emotional relief and exclude conditions requiring treatment. Furthermore, as the Royal Australian and New Zealand College of Radiologists (RANZCR) states: “the risks involved in failing to have a needed medical imaging test include potential missed diagnosis and delayed, inappropriate or lack of necessary treatment”.1

At a population level, the risk–benefit ratio may be more readily assessed. For example, there is justification for mammographic screening of women in target age groups, based on the net reduction in breast cancer mortality.2,3 Conversely, the benefits of full-body CT scanning in healthy adults are not established.4 In Australia, RANZCR does not support the use of diagnostic imaging for screening of asymptomatic patients, except “where there is an evidence-base to support the screening program”.5 National professional bodies provide justification at this higher level, but when considering the individual patient, it is the doctor who makes the risk–benefit analysis.

In years to come, the overuse of higher dose imaging modalities such as CT may lead to an unreasonable population health burden from radiation-induced cancers. It is essential that medically indicated CT scans are performed when the potential detrimental impact on management and diagnosis of not performing the scan outweighs any small theoretical radiation risk.1,6,7 However, it is also important not to discount the potential radiation risks, particularly cumulative effects.7,8 These are more significant for the younger population, for whom the risks are higher and there is more opportunity for repeated imaging.

Our review aims to provide referrers with additional information about radiation and risk when considering the risk–benefit ratio for diagnostic imaging. Although focusing on paediatric CT, the general principles and content apply more broadly to any request for imaging involving radiation exposure.

Radiation and risk

The exposure risk from diagnostic medical imaging is small. However, it is assumed that this risk is cumulative over a lifetime, as the mechanisms for adaptive cellular responses to low doses of radiation remain unclear.911 There are considerable uncertainties in estimating radiation risk at low doses, and this leads to a range of interpretations about risk, as shown by recent commentary in this Journal on the use of CT.68,12

There is irrefutable evidence from epidemiological studies that ionising radiation exposure at high doses is associated with an increase in cancer incidence and morbidity.13 However, quantifying the risk of a low dose (the dose from a single CT scan is below 100 mSv) is complex and contentious. Studies of populations exposed to these low doses are inherently difficult to collate, due to the need for sufficient sample sizes and extensive follow-up to account for radiation-induced cancer latency.9,10,14 It is extremely difficult to observe the weak carcinogenic effects of radiation above the high natural incidence of cancer with any statistical significance and, consequently, the risks at very low levels of exposure may never be precisely known.10,14 Despite these limitations, observational epidemiological studies largely remain the basis for radiation risk modelling.

The most important epidemiological study is the Japan–United States cooperative Life Span Study (LSS) of Japanese atomic bomb survivors, because of the large exposed cohort, including men, women and children, and the extensive long-term follow-up that has been undertaken.13 The most widely accepted model of low-dose risk estimation using current scientific evidence is based predominantly (but not solely) on LSS data, with a linear extrapolation of the risks at high doses with no threshold.9,11,15Arguments against using this model continue,16 and there is some evidence of protective effects from low doses of radiation, or a hormetic response, but these are yet to be confirmed through epidemiological studies.17 Furthermore, there is no observable increase in cancer incidence in areas of high background radiation such as Kerala, India.18

The first epidemiological link between cancer risk and low doses of radiation from CT scans performed on children and young adults has been published very recently. These data strongly support a linear dose–response model and no threshold in the low dose region. The risks are broadly consistent with those recommended in the international system of radiation protection.9,11 Despite the lack of extensive epidemiological evidence, the linear no-threshold (LNT) model remains the most reasonable assumption regarding the dose–response relationship at low levels.9

A framework for estimating the theoretical lifetime attributable risk (LAR) due to low radiation exposures is provided in the Biological Effects of Ionising Radiation (BEIR) VII report.11 The risk estimation predominantly relies on LSS data, although other medically exposed cohorts were also taken into account for assessment of breast and thyroid cancer development. Considerable uncertainties exist in the BEIR VII methodology, due to extrapolation of LSS data to low total dose and low dose rate exposure situations, transporting the risks from the Japanese population to other ethnicities, and sampling variability in the model parameter estimates for the LSS data. However, the age, sex and site-dependent LARs are the best method currently available for estimating the detriment from exposure situations in which doses differ substantially across the body, as is the case for medical imaging exposures.

In the BEIR VII report, rates for all radiation-attributable cancer incidence are about twice the rates for mortality.11 Risk is dependent on sex and the age at which exposure occurred (Box 1). Children are considerably more susceptible to radiation than adults because their cells are more rapidly dividing and not yet mature, and they have more years of remaining lifetime in which a radiation-induced cancer may appear. For example, the risk of radiation-induced fatal cancer from the same magnitude of exposure for a 10-year-old girl is double the risk for a 30-year-old woman, and more than five times the risk for an 80-year-old woman. However, a recent study20 suggests that the risks in middle age may have been underestimated, and this may warrant consideration in the future.

Defining what is acceptable in terms of risk will always be challenging. Human nature tends towards overreaction when presented with a small risk, while larger risks, such as dying from lung cancer due to smoking, are often down-played.21 It is complex to justify imaging, because it potentially provides immediate benefit for a current health problem, while the radiation effects are possible future risks.

Paediatric CT

In countries with advanced health care systems, the number of diagnostic examinations performed each year that use ionising radiation is greater than one per person.22 In Australia, the number of CT examinations is increasing by about 9% every year (Box 2), and while not showing the same rate of growth, the CT imaging rate for children is also increasing.23 The first decrease in CT imaging in more than 15 years occurred in 2010. This is promising, but cannot yet be confirmed as an ongoing trend. Magnetic resonance imaging (MRI) demonstrates continued growth over recent years (Box 2). The increase in CT use can be partly attributed to advances in technology which allow faster scanning times, and hence greater feasibility of using CT for scans on uncooperative, young and/or sick patients.

In 2001, a series of articles2426 generated considerable media coverage in the US about the risks to children from CT scanning. An important realisation then was that CT protocols for adults were sometimes being used on children, with no appreciable adjustment of parameters based on the examination type or patient age.24

As a result of an increased focus on paediatric CT, an Alliance for Radiation Safety in Pediatric Imaging was formed in 2007,27 with RANZCR subsequently becoming a member.1 The key recommendations of the Alliance, through their Image Gently campaign, are to scan only when necessary; reduce or “child-size” the amount of radiation used; scan only the indicated region; and scan once (multiphase scanning is usually not necessary in children).27,28 These points capture the basis for dose reduction in paediatric CT and the radiation protection principles of optimisation and justification. The referrer can influence the process of optimisation, although it is predominantly the responsibility of the practice undertaking the examination and involves a multidisciplinary team of radiologists, radiographers and physicists. The initial justification for the scan is the responsibility of the referrer.

Justifying the scan

A CT examination for an individual child is justified if there is a reasonable likelihood that it will produce a health benefit or inform patient management. Otherwise, the child only receives the potential detrimental radiation effects. The population obtains an advantage when the summed positive health benefits from those whose management is positively influenced by the imaging are greater than the summed detrimental effects. The population also benefits from the ability of diagnostic imaging to identify who may need health intervention, and therefore allow appropriate allocation of health resources. The net positive effects of the CT examination will be greater when the referring doctor applies the principle of justification to ensure unnecessary studies are not performed.9,29 Further net population benefit will be achieved when the studies performed are limited to the required body region and optimised for image quality and dose.

The principle of justification applied to medical radiation exposure situations requires the referring doctor (and radiologist) to weigh the potential benefits of the procedure against the risks of radiation detriment to ensure that there is a net population benefit.9,28 The doctor should consider the objective of the exposure and the individual involved. Prior imaging for the individual should be checked to see if the required diagnostic information has already been acquired. Alternative procedures that do not involve ionising radiation, such as MRI or ultrasound, should also be considered, especially for follow-up imaging.

There are numerous reasons why unnecessary scans may be undertaken, including defensive medicine (fear of litigation from not performing a CT scan); pressure from the public to use “high-tech” examinations; greater availability and access to CT compared with non-ionising radiation modalities; and, in some cases, there is financial incentive to perform more CT scans.30,31 The Professional Services Review in Australia recently reported that CT scans were being initiated without appropriate clinical justification.32 The report suggested that lack of knowledge about particular imaging modalities and using imaging instead of adequate clinical assessment (due to time pressure) may also contribute to inappropriate CT usage.32

The International Commission on Radiological Protection (ICRP) states that justification is the shared responsibility of the requesting clinician and the radiologist.29 If opportunities are not used to educate referring doctors about inappropriate requests, then this lack of knowledge may also contribute to the growth in CT use.31 The referral process may be supported by clinical decision rules and online decision-making tools such as Diagnostic Imaging Pathways, developed and maintained by the Western Australian Department of Health ( RANZCR have also established InsideRadiology, a consumer and referrer information database on medical imaging to encourage informed choice (

It has been suggested that informed consent be obtained for children and young adults undergoing CT examinations.12 Other authors comment on the difficulty of obtaining consent, because the radiation risk is age dependent and cumulative,33 or because of the possibility of a parent refusing a justified CT scan.34 One study surveyed parents of children undergoing CT scans, before and after providing a brochure on radiation safety, and found that the rates of consent to CT scans did not change.35 Informed decision making and support resources may be a viable alternative to informed consent.33 Box 3 provides typical effective doses for paediatric CT examinations with the number of equivalent chest radiographs given as a radiation dose comparator. While it may be desirable to quote a “1-in-x” risk for each type of examination, these types of estimates are not applicable to effective doses. Risk can only be determined from organ-absorbed doses using risk coefficients specific to anatomy, age and sex.


The system of radiation protection is based on the extrapolation of radiation exposure risks at higher doses to the lower doses that are typical of CT imaging, which means that even low doses of ionising radiation are potentially harmful, particularly for children. It will require large-scale, long-term epidemiological studies of CT scan recipients to quantify the risk. The first of many epidemiological studies19 has appeared and supports the assumptions regarding risk, which are used as the basis of radiation protection.

In the past decade, recognition of the potential radiation risks combined with the high use of CT imaging has led to greater awareness of population health risks. These risks can be reduced through education to avoid unnecessary imaging and by ensuring that CT scans are performed with an optimal technique.

Returning to the question about justification of a lumbar spine CT scan for a young female patient with acute lower back pain: if there are no red flags, then conservative management should be trialled first.31,32 Exposure risks associated with diagnostic medical imaging using ionising radiation are unavoidable, but these risks can be appropriately managed and reduced.



There are several factors that referring doctors should consider when requesting a computed tomography (CT) scan, particularly for children and young adults:

  • Is the scan really needed?
  • Will it change management and/or diagnosis, taking into account the severity of the condition?
  • Is there previous appropriate imaging available?
  • Can the same information be obtained without using ionising radiation (eg, magnetic resonance imaging or ultrasound), particularly for follow-up imaging?
  • Has information from a clinical decision-support tool, (eg, Diagnostic Imaging Pathways) been considered?
  • Is enough clinical information provided to ensure the correct examination is undertaken?

Questions to ask the practice carrying out the imaging:

  • Do you have an active optimisation program for radiation dose and image quality?
  • Do you have local diagnostic reference levels for CT examinations?*
  • Are the radiation doses from medical imaging kept as low as reasonably achievable (the ALARA principle) and are protocols modified for follow-up imaging?
  • Are technique factors tailored to paediatric patients?

* Australian national diagnostic reference levels are available for adult CT scans at

Source: MJA (Medical Journal of Australia.)


Meta-Analysis: ACE Inhibitors Associated with Lower Pneumonia Risk.

Angiotensin-converting–enzyme inhibitors may offer some protection against pneumonia, according to a BMJ meta-analysis. An editorialist isn’t so sure.

Researchers looked at almost 40 studies — including cohort studies, case-control studies, and randomized trials — that reported pneumonia outcomes after use of ACE inhibitors, angiotensin-receptor blockers, and control treatments. The data revealed that ACE inhibitors conferred a roughly 30% decrease in risk for pneumonia, when compared with ARBs or control treatments. The effect was particularly pronounced in Asian patients.

The authors speculate that the cough often associated with ACE inhibitors may actually play a part in the protective effect by clearing respiratory tract secretions.

An editorialist finds it “difficult to agree” with the authors’ enthusiasm. She calls for more studies “before we advise patients to put up with their cough because it may prevent them from getting pneumonia.”

Source: BMJ


Invasive Staph Outbreaks Linked to Reuse of Single-Dose Medication Vials.

Two recent outbreaks of invasive Staphylococcus aureus infection were associated with improper use of single-dose or single-use vials for multiple patients, according to an MMWR report.

The outbreaks involved 10 patients in two states: Three patients developed MRSA infections after receiving injections of diluted contrast from the same vial on the same day at an Arizona pain clinic, and seven patients developed methicillin-susceptible S. aureus infection after receiving bupivacaine injections from shared vials during a 3-day period at a Delaware orthopedic clinic. In the Arizona outbreak, testing of unopened vials from the same lot revealed no intrinsic contamination. In the Delaware outbreak, a strain indistinguishable from the outbreak strain was identified in a clinic staff member responsible for preparing the injections.

MMWR‘s editors note that most single-dose medications do not contain preservatives and should not be used for more than one patient.

Source: MMWR


20% of Women Who Have Breast-Conserving Surgery Will Need Another Operation.

One in five women who undergo primary breast-conserving surgery for invasive breast cancer or carcinoma in situ will require another operation within 3 months — highlighting the need to counsel women about reoperation rates and the odds of eventually needing a mastectomy — researchers conclude in BMJ.

Some 55,000 women who underwent breast-conserving surgery in the U.K. over a 3-year period were included in the analysis. Of these, 20% required at least one additional operation (either further breast-conserving surgery or mastectomy) within 3 months of the primary procedure. In addition, of those who underwent a second breast-conserving surgery, 14% required a third operation.

Overall, women with carcinoma in situ were significantly more likely to require a follow-up operation than were those with invasive disease only (30% vs. 18%).

Source: BMJ

Patients with Hemochromatosis Often Have Normal Liver Enzyme Tests.

Family history and transferrin saturation should also be used to diagnose this disorder.

Although hemochromatosis is considered one of the most common genetic disorders, the diagnostic rates reported by most gastroenterology and hepatology clinics are low. Elevated liver enzyme tests commonly result in referral to such clinics, which should increase the probability of finding hemochromatosis but does not. Now, researchers evaluate if genetics contributes to this paradox.

In the Hemochromatosis and Iron Overload Screening (HEIRS) Study (JW Gastroenterol Jun 28 2005), nearly 100,000 primary care patients in North America were screened for iron overload using ferritin, transferrin saturation, and HFE genotype testing. In the current substudy, investigators compared liver transaminase levels of 162 C282Y homozygotes and 1367 C282Y nonhomozygotes. All patients had elevated levels of ferritin (>300 µg/L in men and >200 µg/L in women) and transferrin saturation (>50% in men and >45% in women).

The mean alanine aminotransaminase (ALT) level was lower among C282Y homozygotes than nonhomozygotes in both men (37 IU/L vs. 48 IU/L; P=0.05) and women (24 IU/L vs. 37 IU/L; P=0.003). Similarly, the mean aspartate aminotransaminase (AST) level was lower among C282Y homozygotes than nonhomozygotes in both men (29 IU/L vs. 43 IU/L; P=0.007) and women (25 IU/L vs. 41 IU/L; P=0.001). Furthermore, most C282Y homozygotes had ALT levels <40 IU/L (71% of men and 87% of women).

Comment: Patients with hyperferritinemia who are C282Y homozygotes have lower liver transaminase levels than nonhomozygotes — counter to what we see in other liver diseases. A possible explanation is that deposition of iron in hepatocytes of people with hemochromatosis is not inflammatory and does not lead to elevated liver transaminases until late in the disease. Therefore, clinicians should not rely on liver enzyme values alone to screen for hemochromatosis; family history and transferrin saturation measurements should also be considered.

Source: Journal Watch Gastroenterology

Consider Emergent Angiography for Exsanguinating Pelvic Fracture.

Angioembolization reduced mortality from exsanguination compared with conventional treatment for hemorrhage control.

Multitrauma patients with pelvic fractures are at risk for exsanguination from multiple sources, making management very challenging. Researchers in Germany retrospectively analyzed data from a multicenter pelvic injury registry to compare patient outcomes with angioembolization and with conventional measures for hemorrhage control. Of 152 patients with vascular injuries, 17 underwent angiography (all with effective angioembolization) and 135 received conventional treatment to control bleeding. The indication for angiography was computed tomography–proven pelvic fracture with associated vascular injury, hemodynamic instability, and a persistent drop in hemoglobin.

Mortality did not differ significantly between the embolization and conventional-treatment groups (18% and 33%). However, exsanguination was the cause of death in 21% of patients in the conventional-treatment group versus none of those in the embolization group. Significantly more patients in the embolization group required blood transfusions, developed adult respiratory distress syndrome, and had subsequent neurological deficits.

Comment: These results are difficult to interpret, because there were no specific indications for angiography and it is likely that patients who underwent angiography had greater hemodynamic instability. Trauma centers should develop consensus indications for angiographic embolization for patients with pelvic fractures and, when indicated, undertake the intervention at the earliest opportunity. To prevent death from exsanguination, angiography is an effective early complementary treatment option in unstable patients with pelvic hemorrhage.

Source: Journal Watch Emergency Medicine